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Chinese Journal of Integrative Medicine

, Volume 25, Issue 1, pp 16–22 | Cite as

Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

  • Shi-wei Liu
  • Jie Guo
  • Wei-kang Wu
  • Ze-liang Chen
  • Ning ZhangEmail author
Original Article

Abstract

Objective

To evaluate Chinese medicine (CM) formula Bazheng Powder (八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).

Methods

A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.

Results

A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intentto- treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (P>0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups, respectively (P>0.05).

Conclusion

CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328)

Keywords

Chinese medicine recurrent urinary tract infection randomized control trial 

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Notes

Acknowledgements

We would like to thank Editage for providing editorial assistance. We acknowledge the clinical research group members that participated in data collection and analysis for this study.

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2017

Authors and Affiliations

  • Shi-wei Liu
    • 1
  • Jie Guo
    • 1
  • Wei-kang Wu
    • 2
  • Ze-liang Chen
    • 3
    • 4
  • Ning Zhang
    • 1
    Email author
  1. 1.Department of Nephrology and Endocrinology, Wangjing HospitalChinese Academy of Chinese Medical ScienceBeijingChina
  2. 2.Institute of Integrative MedicineSun Yat-sen UniversityGuangzhouChina
  3. 3.Institute of Disease Control and PreventionAcademy of Military Medical SciencesBeijingChina
  4. 4.Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary MedicineShenyang Agriculture UniversityShenyangChina

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