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Chinese Journal of Integrative Medicine

, Volume 24, Issue 11, pp 867–872 | Cite as

Chinese Medicine Yishen Jiangu Granules (益肾健骨颗粒) on Aromatase Inhibitor-Associated Musculoskeletal Symptoms

  • Xing Zhang
  • Nan Peng
  • Ming-wei Yu
  • Gan-lin Zhang
  • Xu Sun
  • Guo-wang Yang
  • Chen Li
  • Lin Yang
  • Xiao-min WangEmail author
Clinical Experience
  • 38 Downloads

Abstract

Objective

To assess the effectiveness of Yishen Jiangu Granules (益肾健骨颗粒, YSJGG) on aromatase inhibitor-associated musculoskeletal symptoms (AIMSS).

Methods

A single-arm, open-label study was conducted in 34 postmenopausal women with breast cancer who experienced AIMSS. Patients were treated with YSJGG for 12 weeks (12.4 g orally twice daily). The primary outcome was a change in the mean worst pain score of Brief Pain Inventory-Short Form (BPI-SF) over 12 weeks, and the second outcomes included changes in pain severity and pain-related interference of BPI-SF and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Modified Score for the Assessment of Chronic Rheumatoid Affections of the Hands (M-SACRAH), the Functional Assessment of Cancer Therapy-Breast (FACT-B), bone mineral density (BMD) and blood indices such as calcium (Ca), phosphate (P), and alkaline phosphatase (ALP).

Results

Of 37 women recruited, 30 initiated the therapy and 24 were evaluable at 12 weeks. The primary outcome (BPI-SF worst pain scores) achieved a 2.17-point reduction compared with baseline (5.75±1.87 vs 3.58±2.15, P<0.01). There were reductions in pain severity (decreased 1.65, P<0.01) and pain-related interference (decreased 2.55, P<0.01). The changes in WOMAC and M-SACRAH scores were similar to BPI-SF (P<0.05). In the FACT-B, only physical well-being and functional well-being were improved compared with baseline (P<0.05). No clinical differences were found in BMD, Ca, P and ALP.

Conclusion

YSJGG is an effective and well-tolerated agent to reduce AIMSS.

Keywords

aromatase inhibitors breast cancer musculoskeletal symptoms Chinese medicine Yishen Jiangu Granules 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2018

Authors and Affiliations

  • Xing Zhang
    • 1
    • 2
  • Nan Peng
    • 1
  • Ming-wei Yu
    • 1
  • Gan-lin Zhang
    • 1
  • Xu Sun
    • 1
  • Guo-wang Yang
    • 1
  • Chen Li
    • 1
  • Lin Yang
    • 1
  • Xiao-min Wang
    • 1
    Email author
  1. 1.Department of OncologyBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijingChina
  2. 2.Graduate SchoolBeijing University of Chinese MedicineBeijingChina

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