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Clinical study on Yishen Qufeng Shengshi Recipe (益肾祛风胜湿方) for glomerular proteinuria patients: A randomized controlled trial

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Abstract

Objective

To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe (益肾祛风胜湿方, YQSR) in patients with glomerular proteinuria

Methods

A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group (108 cases) and the control group (37 cases) according to a random number table in a ratio of 3:1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR (200 mL, twice per day, orally) and losartan (50 mg/d orally), respectively for 6 months. The 24-h urine protein quantity, blood urea nitrogen, and serum creatinine in the two groups were measured at multiple time points before and after treatment.

Results

At the end of the study, 5 cases were lost to follow-up in the treatment group and 1 in the control group. Finally, the statistical data included 103 cases in the treatment group and 36 cases in the control group. The total effectiveness after 2, 4, and 6 months was 81.6% (84/103), 87.4% (90/103), and 92.2% (95/103), respectively, in the treatment group and 47.2% (17/36), 55.6% (20/36), and 61.1% (22/36), respectively, in the control group, with significant difference between the two groups (P<0.01 at all observation points). In the treatment group, the curative effect after 6 months was better than that after 2 months (P<0.05). The 24-h urine protein quantity was significantly lower in the treatment group at 3, 4, 5, and 6 months than that in the control group (P<0.05 or P<0.01, respectively)

Conclusion

YQSR could significantly reduce the amount of glomerular proteinuria in the early stage.

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Acknowledgements

The authors thank all patients services staff involved in the study for recruiting, screening the eligible patients, and the clinicians for their cooperation.

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Authors and Affiliations

  1. Department of Nephrology, Central Hospital of Xuhui District, Shanghai, 200031, China

    Qin Dai

  2. Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medical, Shanghai, 200021, China

    Qin Dai & Li-qun He

  3. Heilongjiang Academy of Traditional Chinese Medicine, Harbin, 150036, China

    Pei-qing Zhang

  4. Department of Nephrology, Hubei Provincial Traditional Chinese Medical Hospital, Wuhan, 430061, China

    Xiao-qin Wang

  5. Department of Nephrology, Xiyuan Hospital, Beijing, 100091, China

    Li-fang Nie

  6. Department of Nephrology, Jinhua Municipal Hospital of Traditional Chinese Medical, Jinhua, Zhejiang Province, 321017, China

    Xiao-jun Fu

  7. Department of Nephrology, Central Hospital of Shanghai Putuo District, Shanghai, 200062, China

    Wen Peng

  8. Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medical, Shanghai, 200437, China

    Yi Wang

  9. Department of Nephrology, The Fifth Affiliated Hospital of Zunyi Medical College (Zhuhai), Zhuhai, Guangdong Province, 519100, China

    Jun Li

  10. Department of Traditional Chinese Medicine, Shanghai Yinhang Community Health Service Ceter, Shanghai, 200438, China

    Yue-ping Bi

  11. Department of Nephrology, Shanghai Yangpu District Hospital of Traditional Chinese Medical, Shanghai, 200090, China

    Xiu-hua Mi

  12. Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Min Yuan

Authors
  1. Qin Dai
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  2. Pei-qing Zhang
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  3. Xiao-qin Wang
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  4. Li-fang Nie
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  5. Xiao-jun Fu
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  6. Wen Peng
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  7. Yi Wang
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  8. Jun Li
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  9. Yue-ping Bi
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  10. Xiu-hua Mi
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  11. Min Yuan
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  12. Li-qun He
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Corresponding author

Correspondence to Li-qun He.

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Dai, Q., Zhang, Pq., Wang, Xq. et al. Clinical study on Yishen Qufeng Shengshi Recipe (益肾祛风胜湿方) for glomerular proteinuria patients: A randomized controlled trial. Chin. J. Integr. Med. 24, 10–15 (2018). https://doi.org/10.1007/s11655-017-2908-8

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  • DOI: https://doi.org/10.1007/s11655-017-2908-8

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