Babaodan Capsule (八宝丹胶囊) combined with Qingyi Huaji Formula (清胰化积方) in advanced pancreatic cancer—a feasibility study

Long J, Luo GP, Xiao ZW, Liu, ZQ, Long J, Yu XJ. Cancer statistics: current diagnosis and treatment of pancreatic cancer in Shanghai, China. Cancer Lett 2014;346:273–277.CrossRefPubMedGoogle Scholar

Diaz Beveridge R, Alcolea V, Aparicio J, Segura Á, García J, Corbellas M, Fonfría M, et al. Management of advanced pancreatic cancer with gemcitabine plus erlotinib: efficacy and safety results in clinical practice. JOP Jan 2014;15:19–24.Google Scholar

Ouyang H, Wang P, Meng Z, Yu EX, JIN H, David Z Chang, et al. Multimodality treatment of pancreatic cancer with liver metastases using chemotherapy, radiation therapy, and/or Chinese herbal medicine. Pancreas 2011;40:120.CrossRefPubMedPubMedCentralGoogle Scholar

Liu LM, Wu LC, Lin SY, Yang WH, GUO Y, Xu YF, et al. Therapeutic evaluation on advanced pancreatic cancer Treated by Integrative Chinese and western medicine— Clinical analysis of 56 cases. Chin J Integr Med 2003;9:39–43.CrossRefGoogle Scholar

Yehua S, Luming L, Zhen C. Study on Chinese medicine combined with chemotherapy for treatment of 32 cases of advanced pancreatic cancer. J Tradit Chin Med 2006;2:25.Google Scholar

Chen L, Qu C, Chen H, Xu LT, Qi Q, Luo JM, et al. Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PloS One 2014;9:e96177.CrossRefGoogle Scholar

Ouyang HQ, Liu LM, Chen Z, Luo JM, Yu EX. Effects of Qingyi Huaji Decoction on serum levels of interleukin-6, interleukin-8 and tumor necrosis factor-alpha in nude mice bearing pancreatic tumors. J Chin Integr Med (Chin) 2010;8:655–661.CrossRefGoogle Scholar

Wang P, Chen Z, Meng ZQ, Luo JM, Lin JH, Zhou ZH, et al. Ski acts as therapeutic target of qingyihuaji formula in the treatment of SW1990 pancreatic cancer. Integr Cancer Therap 2010;9:50–58.CrossRefGoogle Scholar

Wang P, Liu LM, Chen Z. Effect of Qingyi Huaji Formula for inhibition of pancreatic cancer cell growth through downregulating Ski expression. Chin J Integr Tradit West Med (Chin) 2010;30:942–945.Google Scholar

Yanli X, Feiye Z, Shan X, Liu LM. Anti-tumor effect of the extract from Qingyihuaji Formula on pancreatic cancer by down-regulating Notch-4 and Jagged-1. J Tradit Chin Med (Chin) 2015;35:77–83.CrossRefGoogle Scholar

Yin JH, Shi WD, Zhu XY, Chen Z, Liu LM. Qingyihuaji formula inhibits progress of liver metastases from advanced pancreatic cancer xenograft by targeting to decrease expression of Cyr61 and VEGF. Integr Cancer Ther 2012;11:37–47.CrossRefPubMedGoogle Scholar

Zhang J, Wang P, Ouyang H, Yin JH, Liu AH, Ma CZ, et al. Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer. PLoS One 2013;8:e70334.CrossRefGoogle Scholar

Sobin LH, Wittekind C. For the international union against cancer: TMN: classification of malignant tumors. New York: NY, Wiley-Liss; 2002:87–89.Google Scholar

Yun YH, Mendoza TR, Heo DS, Yoo T, Heo BY, Park HA, et al. Development of a cancer pain assessment tool in Korea: a validation study of a Korean version of the brief pain inventory. Oncology 2004;66:439–444.CrossRefPubMedGoogle Scholar

Hong GB, Zhou JX, Sun HB, Li CY, Song LQ. Continuous transarterial infusion chemotherapy with gemcitabine and 5-Fluorouracil for advanced pancreatic carcinoma. Asian Pacific J Cancer Prevent 2012;13:2669–2673.CrossRefGoogle Scholar

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. Cancer J Clin 2015;65:5–29.CrossRefGoogle Scholar

Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, et al. Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery 2014;156:1–14.CrossRefPubMedGoogle Scholar

Jiang L, Yang KH, Chen Y, Guan QL, Zhao P, Tian GH, et al. Systematic review and meta-analysis of the effectiveness and safety of extended lymphadenectomy in patients with resectable gastric cancer. Br J Sur 2014;101:595–604.CrossRefGoogle Scholar

Reese AS, Lu W, Regine WF. Utilization of intensitymodulated radiation therapy and image-guided radiation therapy in pancreatic cancer: is it beneficial? Seminars Radiat Oncol 2014;24:132.CrossRefGoogle Scholar

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Moore JIM, Seay T,et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. New Eng J Med 2013;36:1691–1703.CrossRefGoogle Scholar

Xu YL, Gao S, Liu LM, Chen Z, Meng ZQ, Lin JH, et al. Clinical analysis on 20 cases of long term survival patients with advanced pancreatic cancer. China J Tradit Chin Med Pharm (Chin) 2014;29:2679–2681.Google Scholar

Zhou Z, Lin JH,. Proliferation inhibition and apoptosis induction of Ba-Bao-Dan (BBD) in human osteosarcoma U-2OS cells. Chin J Tradit Med Traumatol Orthopedics (Chin) 2006:S2.Google Scholar

Wu H, Li H, Qi X, Pei YX. Effects of Babaodan on myeloidderived suppressor cells proportion of the pripheral blood, spleen and bone marrow in colon carcinoma bearing mice. Chin J Tradit Chin Med 2014;29:568–570.Google Scholar

Feng ZQ, Wu LC, Min-he Shen MH, Shu QJ, Deng YC, Guo-liang Shao GL. Clinical observe report of Babao Pellet Compounded of TACE treating the heat toxic and blood stagnation type patients with primary hepatocellular carcinoma. Chin J Tradit Chin Med 2007;25:2404–2407.Google Scholar

Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403–2413.CrossRefPubMedGoogle Scholar

Herrmann R, Bodoky G, Ruhstaller T, Glimelius B, Bajetta E, Schüller J, et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007;25:2212–2217.CrossRefPubMedGoogle Scholar