Chinese medicine for outcomes in colorectal cancer patients: A retrospective clinical study
To investigate the effect of Chinese medicine (CM) on survival of patients with stage II and III colorectal cancer (CRC).
A total of 295 patients who received chemotherapy were assigned to Group 1. The other 171 patients received the same chemotherapy treatment combined with the usage of CM Jianpi Jiedu Formula (健脾解毒方, JPJD) for more than 3 months (Group 2). Patients' survival time, relapse and metastasis, and cause of death were observed. Cox proportional hazard regression models were established for the analysis of the effect of independent factors on the survival prognosis of patients with CRC.
The survival rate of patients in Group 2 was higher than that of Group 1 (P<0.05). Compared with Group 1, the mean survival time was prolonged by 5.594 months and the median survival time was prolonged by 6 months in Group 2 (P=0.004). Cox regression analysis indicated that CM combined with chemotherapy provided signifificant protective effect, as observed with the improvements in the survival rates of CRC patients (P<0.01).
CM can improve the survival rate in patients with stage II and III CRC.
KeywordsChinese medicine integrative medicine Jianpi Jiedu Formula colorectal cancer survival period
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- 4.Wei M, Hu B, Shen K. The progress of experimental research on the treatment of CRC by TCM. Tradit Chin Med J (Chin) 2013;36:1371–1375.Google Scholar
- 5.Bian C, Hong L, Wang H. Effect on treatment of post operational colorectal cancer by Guben Yiliu Decoction combined with capecitabine and its effect on immune function. J North Pharm (Chin) 2013;10:23.Google Scholar
- 6.Lin Q, Wang Y. The effect of traditional Chinese medicine on adverse reaction after chemotherapy in patients with colorectal cancer. Liaoning J Tradit Chinese Med (Chin) 2014;41:110–112.Google Scholar
- 7.Wu G, Yu G, Li J, Xiong F. Short term therapeutic effect on treatment of post operational large intestine carcinoma by Fupi Yiwei Decoction combined with chemotherapy and its effect on immune function. J Chin Mater Med (Chin) 2010;35:782–785.Google Scholar
- 8.Guan J, Yang Y. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the replapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation. Oncol Progr 2010;8:193–195.Google Scholar
- 9.Bai J, Zhang H, Li Y. Discussion on thinking and methods of combined treatment of traditional Chinese medicine and Western medicine of colorectal cancer. Shanxi J Tradit Chin Med (Chin) 2011;32:303–304.Google Scholar
- 10.Dou L, Zhong Y. Clinical and experimental progress in traditional Chinese medicine intervention of colorectal cancer. West J Tradit Chin Med (Chin) 2013;15:81–83.Google Scholar
- 11.Meng J. Experimental research on the effect of anti-tumor metastasis by Huangqin Zhengi Decoction in vitro. J Tianjin Univ Tradit Chin Med (Chin) 2001;20:32–34.Google Scholar
- 12.Yu C, Yu S, Zou X, Wu J. Clinical research on Guanchang Fang's inhibit function on the growth of advanced intestinal cancer and the expression of serum VEGF and miRNA31. J Nanjing Univ Tradit Chin Med (Chin) 2014;10:108–115.Google Scholar
- 13.Li X, Fan Z. Multidrug resistance gene of cancer of colon reversed by Jianpi Jiedu herb. Shandong Med J (Chin) 2012;06:134–138.Google Scholar
- 14.Xu X, Zhang J. Effect of sodium ferlate on moser cells and it's synergetic effect with chemotherapy drugs. Tumor 2002;22:107–108.Google Scholar
- 15.Yu R, ed. Oncology of traditional Chinese medicine. Beijing: Science Press; 1983:255–261.Google Scholar
- 16.Chen Q, Qi N. Study progress in the medical treatment of colorectal cancer with Chinese medicine. Jiangxi J Tradit Chin Med (Chin) 2010;41:78–80.Google Scholar
- 17.Weng G, Ruan J. Progress in the treatment of colorectal cancer with Chinese medicine. Acta Chin Med Pharmacol (Chin) 2010;41:107–111.Google Scholar
- 18.Shi Q, Liu J. Investigate progression of large intestinal cancer by the method of Jianpi Yiqi. Liaoning J Tradit Chin Med (Chin) 2010;37:1179–1181.Google Scholar
- 19.Han L, Pan Y. Research advances on treatment of cancer of large intestine from spleen. Shanhai J Tradit Chin Med (Chin) 2010;44:81–84.Google Scholar
- 20.Zhang S, Zhu W. Longitudinal observation on effects of Chinese traditional medicines on quality of life and negative emotions in colon carcinoma patients during chemotherapy. Chin J Clin Psychol (Chin) 2007;4:125–130.Google Scholar
- 21.Luo L, Yang Y, Li P. Cohort study on the effect of Fuzheng Capsules and Quxie Capsules on the replapse and metastasis of the patients with stage II and III colorectal cancer after radical operation. Chin J Integr Tradit West Med (Chin) 2006;26:677–680.Google Scholar