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Chinese Journal of Integrative Medicine

, Volume 22, Issue 7, pp 490–495 | Cite as

Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

  • Hyun Jun Park
  • Sangmin Choe
  • Nam Cheol ParkEmail author
Original Article

Abstract

Objective

To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study.

Methods

A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-varicocelectomy (V)+placebo (P) group, V+P group, non-V+KRG group (1.5-g KRG daily), and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks.

Results

All groups but not the non-V+P group, showed significant improvements in sperm concentrations, motility, morphology, and viability at the end of the study. However, there were no significant differences in serum follicle-stimulating hormone, luteinizing hormone, and testosterone among groups. The incidence of adverse events was low, and all events were assumed to be unrelated to the treatments administered.

Conclusions

Although the exact mechanism by which KRG improves spermatogenesis remains unclear, KRG may be a useful agent for the treatment of male infertility. Nevertheless, additional studies to evaluate the optimal dose and duration of treatment are needed.

Keywords

Panax ginseng male infertility spermatogenesis 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hyun Jun Park
    • 1
    • 2
  • Sangmin Choe
    • 2
    • 3
  • Nam Cheol Park
    • 1
    • 2
    Email author
  1. 1.Department of UrologyPusan National University School of MedicineBusanRepublic of Korea
  2. 2.Medical Research Institute of Pusan National University HospitalBusanRepublic of Korea
  3. 3.Division of Clinical Pharmacology, Clinical Trial CenterPusan National University HospitalBusanRepublic of Korea

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