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Chinese Journal of Integrative Medicine

, Volume 22, Issue 2, pp 96–100 | Cite as

Short- and long-term effects of Xuezhikang (血脂康), an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels

  • Yan-jun Jia (贾燕珺)
  • Yan Zhang (张 彦)
  • Jun Liu (刘 俊)
  • Yuan-lin Guo (郭远林)
  • Rui-xia Xu (徐瑞霞)
  • Jian-jun Li (李建军)Email author
Original Article

Abstract

Objective

To investigate the short- and long-term effects of Xuezhikang (血脂康, XZK), an extract of cholestin, on proprotein convertase subtilisin/kexin type 9 (PCSK9) level.

Methods

Thirty rats were randomly divided into three groups and were given saline, XZK 1,200 mg/kg or lovastatin 10 mg/kg respectively by daily gavage for 3 days (n=10 for each). Sixteen patients without previous lipid-lowering drug treatment for dyslipidemia received XZK 1,200 mg daily for 8 weeks. Fasting blood samples and liver tissue were collected at day 3 for rats, while the blood samples were obtained at baseline and week 8 from patients. The serum PCSK9 and lipid profile were measured. The expression of hepatic low density lipoprotein (LDL) receptor and sterol regulatory element binding protein 2 (SREBP-2) were measured by real time-PCR.

Results

PCSK9 levels in rats were significantly increased in the XZK and lovastatin groups (P=0.002, P=0.003 vs. control) at day 3, while no significant differences were found in the levels of lipid parameters. PCSK9 levels in patients increased by 34% (P=0.006 vs. baseline) accompanied by total cholesterol and LDL-cholesterol decreased by 22% and 28% P=0.001, P=0.002 vs. baseline). The hepatic mRNA levels of LDL-receptor and SREBP-2 were significantly increased in the XZK and lovastatin groups.

Conclusion

XZK has significant impact on PCSK9 in a short- and long-term manner in both rats and humans. Moreover, the data indicated that as lovastatin, XZK increased PCSK9 levels through SREBP-2 pathway.

Keywords

proprotein convertase subtilisin/kexin type 9 Xuezhikang statin lipid profile Chinese medicine 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Yan-jun Jia (贾燕珺)
    • 1
  • Yan Zhang (张 彦)
    • 1
  • Jun Liu (刘 俊)
    • 1
  • Yuan-lin Guo (郭远林)
    • 1
  • Rui-xia Xu (徐瑞霞)
    • 1
  • Jian-jun Li (李建军)
    • 1
    Email author
  1. 1.Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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