Advertisement

Chinese Journal of Integrative Medicine

, Volume 20, Issue 10, pp 723–728 | Cite as

The contribution of deer velvet antler research to the modern biological medicine

  • Yu-shu Huo (霍玉书)
  • Hong Huo (霍 虹)
  • Jie Zhang (张 洁)
Feature Article

Abstract

Deer velvet antler is the only mammal organ which can continuous regenerate. Currently, international scholars are interested in antler that is defined as a perfect regeneration model of neuro, blood vessel, connective tissue, cartilage, and bones. In 1986, we started to study the separation of active protein and peptide of fresh velvet antler using classic biochemical methods. After entering the 21st century, we further investigated the differentiation of antler proteome from different growth periods using advance differential proteomics approach, and unveiled the correlation between the proteome difference and life cycle. The international antler research has entered the stage of molecular biology, and will no doubt have a profound impact on the modern biomedical fields, such as regenerative medicine, organ degeneration and dysplasia, trauma medicine and anti-inflammatory treatment, growth factor research, as well as creation of new medical thinking.

Keywords

deer antler regenerate Chinese medicine proteomics 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Faucheux C, Nesbitt SA, Horton MA, Price JS. Cells in regenerating deer antler cartilage provide a microenvironment that supports osteoclast differentiation. J Exp Biol 2001;204(Pt 3):443–455.PubMedGoogle Scholar
  2. 2.
    Li C, Suttie JM. Deer antlerogenic periosteum: a piece of postnatally retained embryonic tissue?. Anat Embryol (Berlin) 2001;204:375–388.CrossRefGoogle Scholar
  3. 3.
    Goss RJ. Inhibition of growth and shedding of antlers by sex hormones. Nature 1968;220:83–85.PubMedCrossRefGoogle Scholar
  4. 4.
    Goss RJ, ed. Deer antlers: regeneration, function, and evolution. New York: Academic Press; 1983.Google Scholar
  5. 5.
    Goss RJ. Future directions in antler research. Anatomical Record 1995;241:291–302.PubMedCrossRefGoogle Scholar
  6. 6.
    Gray C, Hukkanen M, Konttinen YT, Terenghi G, Arnett TR, Jones SJ, et al. Rapid neural growth: calcitonin generelated peptide and substance P-containing nerves attain exceptional growth rates in regenerating deer antler. Neuroscience 1992;50:953–963.PubMedCrossRefGoogle Scholar
  7. 7.
    Price JS, Oyajobi BO, Oreffo ROC, Russel RGG. Cells cultured from the growing tip of red deer antler express alkaline phosphatase and proliferate in response to insulinlike growth factor. J Endocrinol 1994;143:R9–R16.PubMedCrossRefGoogle Scholar
  8. 8.
    Korbling M, Estrov Z. Adult stem cells for tissue repair—a new therapeutic concept?. New Engl J Med 2003;349:570–582.PubMedCrossRefGoogle Scholar
  9. 9.
    Rosenthal N. Prometheus’s vulture and the stem-cell promise. New Engl J Med 2003;349:267–274.PubMedCrossRefGoogle Scholar
  10. 10.
    Colitti M, Allen SP, Price JS. Programmed cell death in the regenerating deer antler. J Anat 2005;207:339–351.PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Harty M, Neff AW, King MW, Mescher AL. Regeneration or scarring: an immunologic perspective. Devl Dynam 2003;226:268–279.CrossRefGoogle Scholar
  12. 12.
    Francis SM, Suttie JM. Detection of growth factors and proto-oncogene mRNA in the growing tip of red deer (Cervus elaphus) antler using reverse-transcriptase polymerase chain reaction (RT-PCR). J Exp Zool 1998;28:36–42.CrossRefGoogle Scholar
  13. 13.
    Barrell GK, Davies R, Bailey CI. Immunocytochemical localization of oestrogen receptors in perichondrium of antlers in red deer (Cervus elaphus). Reprod Fertil Devel 1999;11:189–192.CrossRefGoogle Scholar
  14. 14.
    Faucheux C, Horton MA, Price JS. Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. J Bone Miner Res 2002;17:455–464.PubMedCrossRefGoogle Scholar
  15. 15.
    Allen SP, Maden M, Price JS. A role for retinoic acid in regulating the regeneration of deer antlers. Dev Biol 2002;251:409–423.PubMedCrossRefGoogle Scholar
  16. 16.
    Price JS, Oyajobi BO, Nalin AM, Frazer A, Russell RGG, Sandell LJ. Chondrogenesis in the regenerating antler tip of red deer: Collagen types I, IIA, IIB and X expression demonstrated by in situ nucleic acid hybridisation and immunocytochemistry. Dev Dynamics 1996;203:332–347CrossRefGoogle Scholar
  17. 17.
    Szuwart T, Kierdorf H, Kierdorf U, Clemen G. Ultrastructural aspects of cartilage formation, mineralization and degeneration during primary antler growth in fallow deer. Anat Anz 1998;180:501–510.CrossRefGoogle Scholar
  18. 18.
    Chris Tuckwell (2003). Velvet antler a summary of the literature on health benefits. http://www.rirdc.gov.au/reports/DEE/03-084.pdf Google Scholar
  19. 19.
    Park HJ, Lee1 DH, Park SG, Lee SC, Cho S, Kim HK, et al. Proteome analysis of red deer antlers. Proteomics 2004;4:3642–3653.PubMedCrossRefGoogle Scholar
  20. 20.
    Huo Y, Schirf VR, Winters WD. The differential expression of NGFS-like substance from fresh pilose antler of Cervus Nippon Temminck. Biomed Sci Instrum 1997;33:541–543.PubMedGoogle Scholar
  21. 21.
    Huo YS, Huo H. The differential expression of nerve growth factors from fresh poilose antler. Tradit Chin Drug Res Clin Pharm (Chin) 1997;8(2):79–81.Google Scholar
  22. 22.
    Wang F, Mei ZQ, Zhong QL, Wang BX. Antler deer peptide analysis and pharmacology. J Jilin Univ (Sci ed., Chin) 2003;41:111–114.Google Scholar
  23. 23.
    Zhao WH, Huang DQ, Hao DM, Li XJ, Liu XT, Wang BX. Clinidal investigation on how the injection hairy deerhorn auxin cryes the kidney positive form of the osteoporosis. Chin J Tradit Med Trauma Orthop (Chin) 2003;2(11):20–22.Google Scholar
  24. 24.
    Zheng HX, Ren YL, Du S, Lin ZR, Huo YS. Comparatively of freeze-drying velvet antler derr and heating driying research on osteoporosis model by emasculated rats. Chin Arch Tradit Chin Med (Chin) 2004;22:616–618.Google Scholar
  25. 25.
    Lin DY, Huang XN, Ke LJ, Chen XC, Ye XY, Huo YS, et al. Purification and characterization of the proliferation of rat osteoblast-like cells UMR-106 from Pilose Antler. China J Mater Med (Chin) 2005;30:851–855.Google Scholar
  26. 26.
    Zheng HX, Du S, Huo YS. Serum pharmacology research of feeding mouse by powder of freeze-drying velvet antler derr. In: Memoir of HUO Yu-hu. Jilin: Jilin Science Technical Publishing Company; 2014 Vol.2.Google Scholar
  27. 27.
    Gao L, Qiao XL, Liang Z, Zhang LH, Huo YS Zhang YK. Application of online two dimensional liquid chromatography in comatative roteome analysis of antlers with different growing stages. Chin J Chromatography (Chin) 2010;28:146–151.CrossRefGoogle Scholar
  28. 28.
    Qu YY, Gao L, Liang Z, Zhang LH, Huo YS, Zhang YK. Extract methods research of protein from velvet antler deer. Report at 17th Chlomatography. Changsha, 2010:511–512.Google Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Yu-shu Huo (霍玉书)
    • 1
  • Hong Huo (霍 虹)
    • 2
  • Jie Zhang (张 洁)
    • 3
  1. 1.The University of Texas Health Science Center at San AnonioSan AntonioUSA
  2. 2.No.1810 GroupDalian Chemical and Physical Institure of Chinese Academy of Sciencce DalianLiaoning ProvinceChina
  3. 3.Key Lab of Urban Environment and Health, Institute of Urban EnvironmentChinese Academy of SciencesXiamen, Fujian ProvinceChina

Personalised recommendations