Chinese Journal of Integrative Medicine

, Volume 18, Issue 5, pp 345–349 | Cite as

Clinical study on Tongyan Spray (通咽喷雾剂) for post-stroke dysphagia patients: A randomized controlled trial

  • Xue-gong Feng (冯学功)
  • Wen-jie Hao (郝文杰)
  • Zhou Ding (丁 舟)
  • Qiang Sui (隋 强)
  • Huan Guo (郭 欢)
  • Jian Fu (符 健)
Original Article



To observe the effectiveness and safety of Tongyan Spray (通咽喷雾剂) composed of Chinese medicine for post-stroke dysphagia patients.


One hundred and twenty-two post-stroke dysphagia patients were randomly assigned to the treatment group (61 cases) and the control group (61 cases). Basic treatment was given to both groups, with Tongyan Spray additionally used in oropharynx for the treatment group, and the placebo used for the control group. After 28-day treatment, the clinical effect and safety were evaluated according to the standard swallowing assessment (SSA) scale.


One patient dropped out in each group, and 120 patients reached the final analysis of the study. The total effective rate for the treatment group was 71.7% (43/60), higher than 46.7% (28/60) in the control group (P<0.05), and the improvement on SSA scores of the two groups were significantly different after treatment (P<0.05). For grade 1 dysphagia patients (completely depending on nasogastric tube), the effective rate of the treatment group was 40.9% (9/22), and 12.5% (2/16) of the control group, without significant difference (P>0.05), while the improvement of SSA score was significantly different between the two groups after treatment (P<0.05). For grade 2–3 dysphagia patients (oral and nasogastric tube feeding), the total effective rate of the treatment group was 89.5% (34/38), higher than 59.1% (26/44) in the control group (P<0.05), and also the improvement on SSA scores was significantly different between the two groups after treatment (P<0.05).


Tongyan Spray was an effective and safe method for post-stroke dysphagia patients.


post-stroke dysphagia Tongyan Spray 


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  1. 1.
    Han TR, Paik NJ, Park JW. Quantifying swallowing function after stroke: a functional dysphagia scale based on videofluoroscopic studies. Arch Phys Med Rehabilit 2001;82:677–682.CrossRefGoogle Scholar
  2. 2.
    Smithard DG, O’Neill PA, Parks C, Morris J. Complications and outcome after acute stroke. Does dysphagia matter? Stroke 1996;27:1200–1204.PubMedCrossRefGoogle Scholar
  3. 3.
    The 4th National Cerebrovascular Disease Conference. The key points for diagnosis of different cerebrovascular diseases.Chin J Neurol (Chin) 1996;29:379.Google Scholar
  4. 4.
    Smithard DG, O’Neill PA, Park C, England R, Renwick DS, Wyatt R, et al. Can bedside assessment reliably exclude aspiration following acute stroke? Age Ageing 1998;27:99–106.PubMedCrossRefGoogle Scholar
  5. 5.
    Liu ZS, Liu BY, Zhang W, Sun SC, Wang DW, Liu J. Clincal Study on acupuncture treatment for moderate and severe deglutition disorders at the chronic stage of apoplexy. Chin Acupunct Moxib (Chin) 2002;22:291–294.Google Scholar
  6. 6.
    Wang YJ, Lu DH, Cui LY, Li WH, ed. Progress of modern neurology, 3rd ed. Beijing: Science and Technology Document Publishing House; 2004:247.Google Scholar
  7. 7.
    The Encephalopathic Emergency Cooperation Group of the State Administration of Traditional Chinese Medicine. The diagnosis and curative effect assessment standard for stroke. J Beijing Univ Tradit Chin Med (Chin) 1996;19:55–56.Google Scholar
  8. 8.
    Davalos A, Ricart W, Gonzalez HF, Soler S, Marrugat J, Molin A, et al. Effect of malnutrition after acute stroke on clinical outcome. Stroke 1996,27:1028–1032.PubMedCrossRefGoogle Scholar
  9. 9.
    Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R. Dysphagia after stroke: incidence,diagnosis, and pulmonary complications. Stroke 2005;36:2756–2763.PubMedCrossRefGoogle Scholar
  10. 10.
    Feng XG, Cai YF, Deng YH. 30 cases of stroke with pseudobulbar palsy by Tongyan Drops. Chin J Inform Tradit Chin Med (Chin) 2003;10:61–62.Google Scholar
  11. 11.
    Logemann JA. Criteria for studies of treatment for oralpharyngeal dysphagia. Dysphagia 1987;1:193–199.CrossRefGoogle Scholar
  12. 12.
    Xiang DQ, Peng SF, Luo MZ. Care and treatment of patients with cerebrovascular disease dysphagia. West Chin Med J (Chin) 2001;16:379–380.Google Scholar
  13. 13.
    Zheng SY. Comparative study of Zhongjing with ginger and modern pharmacology and the application. Strait Pharm J (Chin) 2002;14:94–95.Google Scholar
  14. 14.
    Zhu SS, ed. New formulations of drugs. Beijing: Chemical Industry Press; 2003:251.Google Scholar
  15. 15.
    Westergren A. Detection of eating difficulties after stroke: a systematic review. Int Nurs Rev 2006;53:143–149.PubMedCrossRefGoogle Scholar
  16. 16.
    Dodds WJ, Logemann JA, Stewart ET. Radiologic assessment of abnormal oraland pharyngeal phases of swallowing. AJR Am J Roentgenol 1990;154:965–974.PubMedGoogle Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Xue-gong Feng (冯学功)
    • 1
  • Wen-jie Hao (郝文杰)
    • 1
  • Zhou Ding (丁 舟)
    • 1
  • Qiang Sui (隋 强)
    • 1
  • Huan Guo (郭 欢)
    • 1
  • Jian Fu (符 健)
    • 1
  1. 1.Neurology Department of Beijng Hospital of Traditional Chinese and Western MedicineBeijingChina

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