Chinese Journal of Integrative Medicine

, Volume 18, Issue 11, pp 807–812

Clinical efficacy of traditional chinese medicine on acute myocardial infarction—A prospective cohort study

  • Wen-hui Duan (段文慧)
  • Fang Lu (陆 芳)
  • Li-zhi Li (李立志)
  • Cheng-long Wang (王承龙)
  • Jian-gang Liu (刘剑刚)
  • Qiao-ning Yang (杨巧宁)
  • Feng Gu (谷 丰)
  • Lei Zhang (张 蕾)
  • Da-zhuo Shi (史大卓)
Original Article

DOI: 10.1007/s11655-012-1116-9

Cite this article as:
Duan, W., Lu, F., Li, L. et al. Chin. J. Integr. Med. (2012) 18: 807. doi:10.1007/s11655-012-1116-9

Abstract

Objective

To evaluate the clinical effects of Chinese medicine (CM) on acute myocardial infarction (AMI) with a prospective cohort study.

Methods

A total of 334 AMI patients from January 2007 to March 2009 were consecutively enrolled, and were assigned to a treatment group (169 cases) treated with combined therapy (CM for at least one month and Western medicine) and a control group (165 cases) with Western medicine alone. Clinical data including age, gender, smoking, medical history, infarction area, heart functional classification, CM syndrome scores, blood-stasis syndrome score, primary end-point (death, nonfatal myocardial infarction, and revascularization) and secondary end-point (ischemic stroke, rehospitalization due to angina, heart failure and shock), were collected. CM syndrome scores, blood-stasis syndrome score, primary end-point and secondary end-point were collected during the 6-month follow-up. Kaplan-Meier method was used for the survival analysis. The multifactor analysis was analyzed by Cox proportional hazards regression.

Results

At the end of 6-month the CM syndrome score and bloodstasis syndrome score in the treatment group were lower than those in the control group (P<0.01), especially the symptoms of chest pain, spontaneous perspiration and insomnia. Rehospitalization rate due to angina during the 6-month follow-up in the treatment group (2.96%) was lower than that in the control group (7.88%, P<0.05). Kaplan- Meier survival curve showed that event-free cumulated survival of rehospitalization due to angina during the 6-month follow-up in the treatment group was higher than that in the control group (Log rank 4.700, P=0.03). Cox regression analysis showed that heart dysfunction [hazard ratio (HR)=1.601, 95% CI=1.084–2.364, P=0.018] and diabetes mellitus (HR=1.755, 95% CI=1.031–2.989, P=0.038) were hazard factors to end-point, whereas CM (HR 0.405, 95% CI=0.231–0.712, P=0.002), percutaneous coronary intervention (PCI, HR=0.352, 95% CI=0.204–0.607, P<0.001) and angiotensin converting enzyme (ACE) inhibitors (HR=0.541, 95% CI=0.313–0.936, P=0.028) were protective factors.

Conclusions

CM therapy could decrease CM syndrome scores and blood-stasis syndrome score, reduce the rehospitalization rate during 6-month follow-up due to angina. Heart dysfunction and diabetes mellitus were hazard factors to end-point, whereas CM, PCI and ACE inhibitors were protective factors.

Keyword

acute myocardial infarction Chinese medicine survival analysis cohort study 

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Wen-hui Duan (段文慧)
    • 1
  • Fang Lu (陆 芳)
    • 1
  • Li-zhi Li (李立志)
    • 1
  • Cheng-long Wang (王承龙)
    • 1
  • Jian-gang Liu (刘剑刚)
    • 1
  • Qiao-ning Yang (杨巧宁)
    • 1
  • Feng Gu (谷 丰)
    • 1
  • Lei Zhang (张 蕾)
    • 1
  • Da-zhuo Shi (史大卓)
    • 1
  1. 1.Cardiovascular Diseases Center, Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijingChina

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