Advertisement

Chinese Journal of Integrative Medicine

, Volume 17, Issue 11, pp 811–817 | Cite as

Chinese medicine pattern diagnosis could lead to innovation in medical sciences

  • Ai-ping Lu (吕爱平)
  • Ke-ji Chen (陈可冀)
Feature Article

Abstract

Chinese medicine (CM) pattern diagnosis (Bian zheng or syndrome differentiation), as another patient classification approach, has been incorporated with biomedicine diagnosis in clinical practice in China, and the clinical experience has proven that the integration of biomedicine and CM is better in the treatment of many diseases. CM pattern diagnosis is completely different from the diagnosis in biomedicine, and it must take an active role in innovation for medical sciences. This paper is trying to discuss how CM pattern diagnosis lead to innovations in basic research, clinical research and new drug discovery. Scientific basis of CM pattern in innovation of basic research, clinical efficacy and safety, CM pattern based clinical trial design, CM pattern and clinical practice guideline in innovation of clinical study, CM pattern based indication finding, and CM pattern based network pharmacology in innovation of new drug discovery have been discussed.

Keywords

Chinese medicine pattern diagnosis innovation in medical sciences 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lu AP, Chen KJ. Integrative medicine in clinical practice: from pattern differentiation in traditional Chinese medicine to disease treatment. Chin J Integr Med 2009;15:152.PubMedCrossRefGoogle Scholar
  2. 2.
    Zhang Q, Wu Z, Feng Y, Shi J. Levels of sexual hormones in relation with syndrome-differentiation of traditional Chinese medicine in patients of chronic renal failure. J Tradit Chin Med 1990;10:132–135.PubMedGoogle Scholar
  3. 3.
    Zha QL, He YT, Yu JP. Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model. Chin J Integr Tradit West Med (Chin) 2006;26:871–876.Google Scholar
  4. 4.
    Xu H, Chen KJ. Making evidence-based decisions in the clinical practice of integrative medicine. Chin J Integr Med 2010;16:483–485.PubMedCrossRefGoogle Scholar
  5. 5.
    Lu AP, Zhang SS, Zha QL, Ju DH, Wu H, Jia HW, et al. Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacterpylori infection and symptoms in patients with chronic gastritis. World J Gastroenterol 2005;11:2486–2490.PubMedGoogle Scholar
  6. 6.
    Lu AP. Think much of the study on TCM syndrome differentiation of rheumatoid arthritis. Chin J Integr Tradit West Med (Chin) 2007;27:587–588.Google Scholar
  7. 7.
    Li Y, Li S, Lu AP. Comparative analysis via data mining on the clinical features of Western medicine and Chinese medicine in diagnosing rheumatoid arthritis. Chin J Integr Tradit West Med (Chin) 2006;26:988–991.Google Scholar
  8. 8.
    Lu C, Zha Q, Chang A, He Y, Lu A. Pattern differentiation in traditional Chinese Medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis. J Altern Complement Med 2009;15:1021–1025.PubMedCrossRefGoogle Scholar
  9. 9.
    Zhou X, Zhou Z, Jin M, Wang H, Wu M, Gu Q, et al. Intermediate and late rheumatoid arthritis treated by tonifying the kidney, resolving phlegm and removing blood stasis. J Tradit Chin Med 2000;20:87–92.PubMedGoogle Scholar
  10. 10.
    Li HX, Han SY, Wang XW, Ma X, Zhang K, Wang L, et al. Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats. Food Chem Toxicol 2009;47:1797–1802.PubMedCrossRefGoogle Scholar
  11. 11.
    Yuan GQ, Jia ZH, Yang HT, Wu SZ, Gao HL, Wei C, et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: a possible mechanism of vascular endothelial dysfunction. Chin J Integr Med 2010;16:54–60.PubMedCrossRefGoogle Scholar
  12. 12.
    Zha Q, He Y, Lu Y, Lu A. Relationship between platelet counts and cartilage erosion in 436 cases of rheumatoid arthritis. Clin Chim Acta 2006;371:194–195.PubMedCrossRefGoogle Scholar
  13. 13.
    He Y, Zha Q, Liu D, Lu A. Relations between serum IgA level and cartilage erosion in 436 cases of rheumatoid arthritis. Immunol Invest 2007;36:285–291.PubMedCrossRefGoogle Scholar
  14. 14.
    Yang W, Ouyang J, Zhu K, Zhou S, Peng Z. Traditional Chinese medicine treatment for 40 cases of rheumatoid arthritis with channel blockage due to yin deficiency. J Tradit Chin Med 2003;23:172–174.PubMedGoogle Scholar
  15. 15.
    Swanson DR. Medical literature as a potential source of new knowledge. Bull Med Libr Assoc 1990;78:29–37.PubMedGoogle Scholar
  16. 16.
    Daraselia N, Yuryev A, Egorov S, Novichkova S, Nikitin A, Mazo I. Extracting human protein interactions from MEDLINE using a full-sentence parser. Bioinformatics 2004;20:604–611.PubMedCrossRefGoogle Scholar
  17. 17.
    Zhou X, Liu B, Wu Z, Feng Y. Integrative mining of traditional Chinese medicine literature and MEDLINE for functional gene networks. Artif Intell Med 2007;41:87–104.PubMedCrossRefGoogle Scholar
  18. 18.
    Zheng G, Jiang M, He X, Zhao J, Guo H, Chen G, et al. Discrete derivative: a data slicing algorithm for exploration of sharing biological networks between rheumatoid arthritis and coronary heart disease. BioData Min 2011;4:18.PubMedCrossRefGoogle Scholar
  19. 19.
    Ding X, Zha Q, Lu A. Seeking potential biological network shared in rheumatoid arthritis and ulcerative colitis through text mining. Bioinformatics and Biomedical Engineering 2009. ICBBE 2009Google Scholar
  20. 20.
    Ding X, Zha Q, Lu A. Getting started in text mining to find the biological network shared with rheumatoid arthritis, coronary heart disease and diabetes mellitus. Bioinformatics and Biomedicine Workshops 2010. BIBMW 2010.Google Scholar
  21. 21.
    He Y, Lu A, Zha Y, Yan X, Song Y, Zeng S, et al. Correlations between symptoms as assessed in traditional Chinese medicine (TCM) and ACR20 efficacy response: a comparison study in 396 patients with rheumatoid arthritis treated with traditional Chinese medicine or Western medicine. J Clin Rheumatol 2007;13:317–321.PubMedCrossRefGoogle Scholar
  22. 22.
    van Wietmarschen H, Yuan K, Lu C, Gao P, Wang J, Xiao C, et al. Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients. J Clin Rheumatol 2009;15:330–337.PubMedCrossRefGoogle Scholar
  23. 23.
    Zhang C, Zha QL, He YT, Jiang M, Lu C, Lu AP. The extraarticular symptoms influence ACR response in the treatment of rheumatoid arthritis with biomedicine: a single-blind, randomized, controlled, multicenter trial in 194 patients. J Tradit Chin Med 2011;31:50–55.PubMedCrossRefGoogle Scholar
  24. 24.
    Jiang M, Zha Q, Lu C, He Y, Lu A. Association between tongue appearance in traditional Chinese medicine and effective response in treatment of rheumatoid arthritis. Complement Ther Med 2011;19:115–121.PubMedCrossRefGoogle Scholar
  25. 25.
    Jiang M, Zha Q, He Yi, Lu A. Risk factors of adverse drug reactions in the treatment of rheumatoid arthritis with biomedical combination and Chinese herbal medicine therapy. J Ethnopharmacol 2011. In pressGoogle Scholar
  26. 26.
    Li J, Lu Y, Xiao C, Lu C, Niu X, He X, et al. Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol 2011;135:270–277.PubMedCrossRefGoogle Scholar
  27. 27.
    Zhang C, Jiang M, Lu A. A traditional Chinese medicine versus Western combination therapy in the treatment of rheumatoid arthritis: two-stage study protocol for a randomized controlled trial. Trials 2011;12:137.PubMedCrossRefGoogle Scholar
  28. 28.
    Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature 2004;429:464–468.PubMedCrossRefGoogle Scholar
  29. 29.
    He Y, Lu A, Zha Y, Yan X, Song Y, Zeng S, et al. Correlations between symptoms and ACR20 efficacy in 396 cases of rheumatoid arthritis. J Clin Rheumatol 2007;13:317–321.PubMedCrossRefGoogle Scholar
  30. 30.
    Andrew L Hopkins. Network pharmacology. Nature Biotechnolo 2007;25:1110–1111.CrossRefGoogle Scholar
  31. 31.
    Chen G, Liu B, Jiang M, Tan Y, Lu A. Functional networks for Salvia miltiorrhiza and Panax notoginseng in combination explored with text mining and bioinformatical approach. JMPR 2011;23 [Epub ahead of print]Google Scholar
  32. 32.
    Lu C, Xiao C, Chen G, Jiang M, Zha Q, Yan X, et al. Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell. Rheumatol Int 2010. [PubMed: 20658292] [Epub ahead of print]Google Scholar
  33. 33.
    Ma XH, Zheng CJ, Han LY, Xie B, Jia J, Cao ZW, et al. Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discov Today 2009;14:579–588.PubMedCrossRefGoogle Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Ai-ping Lu (吕爱平)
    • 1
  • Ke-ji Chen (陈可冀)
    • 2
  1. 1.Institute of Basic Research in Clinical MedicineChinese Academy of Chinese Medical SciencesBeijingChina
  2. 2.Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijingChina

Personalised recommendations