Chinese Journal of Integrative Medicine

, Volume 16, Issue 2, pp 119–123

Effect of Xuezhikang Capsule (血脂康胶囊) on serum tumor necrosis factor-α and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia

  • Xiao-fen Fan (范小芬)
  • Yin-quan Deng (邓银泉)
  • Lei Ye (叶 蕾)
  • You-di Li (李友第)
  • Jiu Chen (陈 玖)
  • Wen-wen Lu (卢雯雯)
  • Jian-ping Li (李剑平)
Original Article

DOI: 10.1007/s11655-010-0119-7

Cite this article as:
Fan, X., Deng, Y., Ye, L. et al. Chin. J. Integr. Med. (2010) 16: 119. doi:10.1007/s11655-010-0119-7

Abstract

Objective

To evaluate the effect of Xuezhikang Capsule (血脂康胶囊) on the serum levels of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia, and to explore whether it has anti-inflammatory effect.

Methods

A total of 84 patients were randomly assigned to two groups with stratified block randomization, the treatment group (42 cases) and the control group (42 cases). They were treated with Xuezhikang Capsule and polyene phosphatidylcholine capsule for twenty-four weeks, respectively. The changes in serum TNF-α and IL-6 were measured by enzyme linked immunosorbent assay before treatment and at the 12th and 24th week.

Results

Compared with those before treatment, the serum levels of TNF-α and IL-6 significantly decreased in both groups after treatment (P<0.01). There was no significant change between the two groups for the treatments at different time points (P>0.05) and between the two groups for treatments at the same time points (P>0.05).

Conclusion

Xuezhikang Capsule can inhibit the serum inflammatory factor in patients with NAFLD and hyperlipidemia.

Key Words

Xuezhikang Capsule nonalcoholic fatty liver disease hyperlipidemia tumor necrosis factor-α interleukin-6 

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Xiao-fen Fan (范小芬)
    • 1
  • Yin-quan Deng (邓银泉)
    • 1
  • Lei Ye (叶 蕾)
    • 2
  • You-di Li (李友第)
    • 1
  • Jiu Chen (陈 玖)
    • 1
  • Wen-wen Lu (卢雯雯)
    • 1
  • Jian-ping Li (李剑平)
    • 1
  1. 1.Department of Traditional Chinese Medicine, The First Affiliated Hospital, College of MedicineZhejiang UniversityHangzhouChina
  2. 2.Department of HepatologyZhejiang Hospital of Traditional Chinese MedicineHangzhouChina

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