Chinese Journal of Integrative Medicine

, Volume 16, Issue 2, pp 114–118

Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence

  • Chun Gong (龚 春)
  • Shao-lie Huang (黄绍烈)
  • Jian-feng Huang (黄剑峰)
  • Zhi-fang Zhang (章志芳)
  • Ming Luo (罗 鸣)
  • Yu Zhao (赵 宇)
  • Xiao-jie Jiang (江小杰)
Original Articles

Abstract

Objective

To observe the effect of combined therapy with Xuezhikang Capsule (血脂康胶囊, XZK) and Valsartan on left ventricular hypertrophy (LVH) and heart rate turbulence (HRT) in hypertensive patients.

Methods

Ninety primary hypertensive patients with LVH were randomly assigned to three groups. Basic treatment, including aspirin, β-blockers, calcium antagonists, etc. were administered to all patients. Additionally, Valsartan (VS, 80 mg once a day) was given to the 30 patients in the VS group. Valsartan (in the same dosage) and XZK (600 mg, twice a day) were given to the 32 patients in the Chinese medicine (CM) group, while none was given to the 28 patients in the control group. The therapeutic course lasted for 24 months. Changes in left ventricular mass index (LVMI) measured by cardiac ultrasonic indices, HRT parameters, including the original heart rate (TO) and slope coeffificient (TS), systolic and diastolic blood pressures (SBP and DBP), as well as blood cholesterol level (TC) were measured before and after treatment.

Results

After treatment, TO and LVMI were lowered, while TS increased in both the VS group and the CM group (P<0.01), but changed insignificantly in the control group. Significant differences between the CM group and the control group were shown in terms of TO, LVMI, SBP, DBP and TS (P<0.01); and between the CM group and the VS group in terms of TO, LVMI and TS (P<0.01). Moreover, HRT parameters showed an evident correlation with LVMI (r=0.519–0.635, P<0.01).

Conclusion

Combined therapy with XZK and Valsartan can improve hypertensive LVH and HRT parameters, and lessen the damage on the autonomous nervous system.

Keywords

heart rate turbulence left ventricular hypertrophy hypertension Xuezhikang Capsule Valsartan 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Chun Gong (龚 春)
    • 1
  • Shao-lie Huang (黄绍烈)
    • 2
  • Jian-feng Huang (黄剑峰)
    • 2
  • Zhi-fang Zhang (章志芳)
    • 3
  • Ming Luo (罗 鸣)
    • 4
  • Yu Zhao (赵 宇)
    • 5
  • Xiao-jie Jiang (江小杰)
    • 1
  1. 1.The Cardiovascular Departmentthe First Affiliated Hospital of Nanchang UniversityNanchangChina
  2. 2.The Ultrasonic Departmentthe First Affiliated Hospital of Nanchang UniversityNanchangChina
  3. 3.Fengcheng Municipal Hospital of Traditional Chinese MedicineFengchengChina
  4. 4.The Dynamic ECG Departmentthe First Affiliated Hospital of Nanchang UniversityNanchangChina
  5. 5.The Cardiovascular Departmentthe Fourth Affiliated Hospital of Nanchang UniversityNanchangChina

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