Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

  • Ya-chen Zhang (张亚臣)
  • Bao-jing Lu (吕宝经)
  • Mei-hua Zhao (赵美华)
  • Ye-zhi Rong (荣烨之)
  • Rui-ming Chen (陈瑞明)
Original Article



To study the effect of Shengmai injection (生脉注射液, SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM).


One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin II (Ang II), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment.


After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8 ± 33.1 μ mol/L to 120.1 ± 50.8 μ mol/L, and ET-1 was lowered from 70.1 ± 32.1 ng/L to 46.2 ± 21.3 ng/L, respectively (P<0.01); that of Ang II was lowered from 81.3 ± 24.3 ng/L to 50.2 ± 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 ± 26.3% to 459.3 ± 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 ± 5% to 68 ± 6% (P<0.01), all the changes being more significant than those in the control group (all P<0.01).


SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.

Key Words

Shengmai injection coronary heart disease diabetes mellitus vascular endothelial function heart function 


  1. 1.
    Drexler H. Endothelial dysfunction: clinical implications. Prog Cardiovasc Dis 1997;39:287–324.PubMedCrossRefGoogle Scholar
  2. 2.
    Kjaer A, Meyer C, Nielsen FS, et al. Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes. J Nucl Med 2003;44:19–23.PubMedGoogle Scholar
  3. 3.
    Rask-Madsen C, Ihlemann N, Krarup T, et al. Torp-Pedersen C: Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes 2001;50:2611–2618.PubMedCrossRefGoogle Scholar
  4. 4.
    Miki Horigome, Naoya Hattori, Mitsuaki Horigome, et al. Quantitative measurements of coronary endothelial function in type 2 diabetic patients with coronary risk factors. Circ J 2007; 71(Suppl):296p.Google Scholar
  5. 5.
    Zhang YC, Chen RM, Zhao MH, et al. Effect of Shengmai Injection (生脉注射液) on hemodynamics in patients with dilated cardiomyopathy. Chin J Integr Tradit West Med (Chin) 2002;22(4):277–279.Google Scholar
  6. 6.
    Chen YM, Yang JX, Sha W, et al. Effect of Sheng-mai-san injection vs Astragalus membranaceus injection in treating coronary heart disease with left ventricular dysfunction. Chin J New Drugs Clin Remedies (Chin) 1998;17(3):27–29.Google Scholar
  7. 7.
    Zhang YC, Zhao MH, Lu BJ, et al. Effects of Shengmai injection in the treatment of acute myocardial infarction with left ventricular dysfunction. Acad J Shanghai Second Med Univ 2004;24(8):692.Google Scholar
  8. 8.
    Celermajer DS, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111–1115.PubMedCrossRefGoogle Scholar
  9. 9.
    Rubanyi GM. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 1993;22(Suppl 4):S1–S14.PubMedCrossRefGoogle Scholar
  10. 10.
    Vogel RA. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin Cardiol 1997;20:426–432.PubMedCrossRefGoogle Scholar
  11. 11.
    Celermajer DS, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111–1115.PubMedCrossRefGoogle Scholar
  12. 12.
    Arcaro G, Cretti A, Balzano S, et al. Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 2002;105:576–582.PubMedCrossRefGoogle Scholar
  13. 13.
    Lu BJ, Rong YZ, Zhao MH, et al. Effect of Shengmaisan (生脉散) on lipid peroxidation damage in acute myocardial infarction patients. Chin J Integr Tradit West Med 1996;2(4):249–251.Google Scholar
  14. 14.
    Zhang YC, Cheng RM, Lu BJ, et al. Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome. Chin J Integr Med 2008;14(2):107–110.PubMedCrossRefGoogle Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag GmbH 2008

Authors and Affiliations

  • Ya-chen Zhang (张亚臣)
    • 1
  • Bao-jing Lu (吕宝经)
    • 1
  • Mei-hua Zhao (赵美华)
    • 1
  • Ye-zhi Rong (荣烨之)
    • 2
  • Rui-ming Chen (陈瑞明)
    • 2
  1. 1.Department of Internal CardiologyXinhua Hospital Affiliated to Shanghai Jiaotong UniversityShanghaiChina
  2. 2.Department of Laboratory, Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

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