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Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

  • Ya-chen Zhang (张亚臣)
  • Bao-jing Lu (吕宝经)
  • Mei-hua Zhao (赵美华)
  • Ye-zhi Rong (荣烨之)
  • Rui-ming Chen (陈瑞明)
Original Article

Abstract

Objective

To study the effect of Shengmai injection (生脉注射液, SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM).

Methods

One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin II (Ang II), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment.

Results

After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8 ± 33.1 μ mol/L to 120.1 ± 50.8 μ mol/L, and ET-1 was lowered from 70.1 ± 32.1 ng/L to 46.2 ± 21.3 ng/L, respectively (P<0.01); that of Ang II was lowered from 81.3 ± 24.3 ng/L to 50.2 ± 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 ± 26.3% to 459.3 ± 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 ± 5% to 68 ± 6% (P<0.01), all the changes being more significant than those in the control group (all P<0.01).

Conclusion

SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.

Key Words

Shengmai injection coronary heart disease diabetes mellitus vascular endothelial function heart function 

References

  1. 1.
    Drexler H. Endothelial dysfunction: clinical implications. Prog Cardiovasc Dis 1997;39:287–324.PubMedCrossRefGoogle Scholar
  2. 2.
    Kjaer A, Meyer C, Nielsen FS, et al. Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes. J Nucl Med 2003;44:19–23.PubMedGoogle Scholar
  3. 3.
    Rask-Madsen C, Ihlemann N, Krarup T, et al. Torp-Pedersen C: Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes 2001;50:2611–2618.PubMedCrossRefGoogle Scholar
  4. 4.
    Miki Horigome, Naoya Hattori, Mitsuaki Horigome, et al. Quantitative measurements of coronary endothelial function in type 2 diabetic patients with coronary risk factors. Circ J 2007; 71(Suppl):296p.Google Scholar
  5. 5.
    Zhang YC, Chen RM, Zhao MH, et al. Effect of Shengmai Injection (生脉注射液) on hemodynamics in patients with dilated cardiomyopathy. Chin J Integr Tradit West Med (Chin) 2002;22(4):277–279.Google Scholar
  6. 6.
    Chen YM, Yang JX, Sha W, et al. Effect of Sheng-mai-san injection vs Astragalus membranaceus injection in treating coronary heart disease with left ventricular dysfunction. Chin J New Drugs Clin Remedies (Chin) 1998;17(3):27–29.Google Scholar
  7. 7.
    Zhang YC, Zhao MH, Lu BJ, et al. Effects of Shengmai injection in the treatment of acute myocardial infarction with left ventricular dysfunction. Acad J Shanghai Second Med Univ 2004;24(8):692.Google Scholar
  8. 8.
    Celermajer DS, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111–1115.PubMedCrossRefGoogle Scholar
  9. 9.
    Rubanyi GM. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 1993;22(Suppl 4):S1–S14.PubMedCrossRefGoogle Scholar
  10. 10.
    Vogel RA. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin Cardiol 1997;20:426–432.PubMedCrossRefGoogle Scholar
  11. 11.
    Celermajer DS, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111–1115.PubMedCrossRefGoogle Scholar
  12. 12.
    Arcaro G, Cretti A, Balzano S, et al. Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 2002;105:576–582.PubMedCrossRefGoogle Scholar
  13. 13.
    Lu BJ, Rong YZ, Zhao MH, et al. Effect of Shengmaisan (生脉散) on lipid peroxidation damage in acute myocardial infarction patients. Chin J Integr Tradit West Med 1996;2(4):249–251.Google Scholar
  14. 14.
    Zhang YC, Cheng RM, Lu BJ, et al. Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome. Chin J Integr Med 2008;14(2):107–110.PubMedCrossRefGoogle Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag GmbH 2008

Authors and Affiliations

  • Ya-chen Zhang (张亚臣)
    • 1
  • Bao-jing Lu (吕宝经)
    • 1
  • Mei-hua Zhao (赵美华)
    • 1
  • Ye-zhi Rong (荣烨之)
    • 2
  • Rui-ming Chen (陈瑞明)
    • 2
  1. 1.Department of Internal CardiologyXinhua Hospital Affiliated to Shanghai Jiaotong UniversityShanghaiChina
  2. 2.Department of Laboratory, Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

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