Chinese Journal of Integrative Medicine

, Volume 14, Issue 1, pp 56–60 | Cite as

Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

  • Fu-rong Lu (卢芙蓉)
  • Lin Shen (沈霖)
  • You Qin (秦铀)
  • Lan Gao (高兰)
  • Heng Li (李恒)
  • Yi Dai (戴燚)
Clinical Experience

Abstract

Objective

To evaluate the efficacy and safety of trigonella foenum-graecum L. total saponins (TFGs) in combination with sulfonylureas (SU) in the treatment of patients with type 2 diabetes mellitus (T2DM) not well controlled by SU alone.

Methods

Sixty-nine T2DM patients whose blood glucose levels were not well controlled by oral sulfonylureas hypoglycemic drug were randomly assigned to the treated group (46 cases) and the control group (23 cases), and were given TFGs or placebo three times per day, 6 pills each time for 12 weeks, respectively. Meanwhile, the patients continued taking their original hypoglycemic drugs. The following indexes, including effects on traditional Chinese medicine (TCM) symptoms, fast blood glucose (FBG), 2-h post-prandial blood glucose (2h PBG), glycosylated hemoglobin (HbA1c), clinical symptomatic quantitative scores (CSQS), body mass index (BMI), as well as hepatic and renal functions, were observed and compared before and after treatment.

Results

The efficacy on TCM symptoms was obviously better in the treated group than that in the control group (P<0.01), and there were statistically remarkable decreases in aspect of FBG, 2h PBG, HbA1c and CSQS in the treated group as compared to those in the control group (P<0.05 or P<0.01), while no signifiClassifi cationcant difference was found in BMI, hepatic and renal functions between the two groups (P>0.05).

Conclusion

The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM, and the therapy was relatively safe.

Key Words

trigonella foenum-graecum L. type 2 diabetes mellitus sulfonylureas 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag GmbH 2008

Authors and Affiliations

  • Fu-rong Lu (卢芙蓉)
    • 1
  • Lin Shen (沈霖)
    • 1
  • You Qin (秦铀)
    • 1
  • Lan Gao (高兰)
    • 1
  • Heng Li (李恒)
    • 1
  • Yi Dai (戴燚)
    • 1
  1. 1.Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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