Chinese Journal of Integrative Medicine

, Volume 13, Issue 4, pp 312–316 | Cite as

Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica



Psoriasis is a common, chronic, recurrent inflammatory skin disorder whose etiology is still unknown. It is believed that a multiple-gene inheritance is involved and it also involves various factors such as immunity, inflammation, cell proliferation, apoptosis, neural media, etc. Since cytokines are key mediators in inflammation, a number of Chinese medicines (CMs) have been reported to have certain antagonist effects on pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), platelet active factor (PAF) and interleukin-8 (IL-8). Some researches on CMs have made significant breakthroughs in psoriasis by intervening with cytokines. Abnormalities with keratinocyte proliferation and apoptosis are considered to be present in patients with psoriasis and a number of studies show that the mechanism of CMs on psoriasis may be through the inhibition of the keratinocyte proliferation and induction of apoptosis. Other studies also show that the inhibition of fibroblast-secreted cytokines could regulate keratinocyte proliferation and differentiation and reduce the level of Calcitonin gene-related peptide (CGRP) in plasma and in lesions so as to slow down the process of inflammation and proliferation in psoriasis. The most commonly used models for psoriasis are the scaled tails or the vaginal epithelium of mice in China. They were used to observe the histopathological changes after the model mice were treated with CMs with the inhibition on the mitosis of vaginal epithelium or promotion of granular layer in rat tail taken as the indices of clinical efficacy. A variety of signs occur in psoriasis patients with TCM blood-stasis syndrome type and the effect of CMs in activating blood circulation to remove blood stasis on psoriasis suggested that the mechanism of CMs may be partially correlated to hemorrheology and microcirculation. Along with the continuous development of the biosciences, some TCM theories for psoriasis have been confirmed by laboratory studies. However, the exploration into traditional Chinese medicines’ biomechanics in psoriasis and the therapeutic mechanism of CMs by integrative medicine still requires further studies.

Key Words

Chinese herb medicine psoriasis experimental studies 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Qin WZ. Studies on treatment of psoriasis with integrative medicine. Chin J Integr Med (Chin) 2002; 8(4):248–255.Google Scholar
  2. 2.
    Bonifati C, Ameglio F. Cytokines in psoriasis. Int J Dermatol 1999;38:241–251.PubMedCrossRefGoogle Scholar
  3. 3.
    Yuan JS, Zhou LP, Hu CF, et al. Influence on antibody bridging keratinocyte/mononuclear leucocyte adhesion of patients with psoriasis by Chinese herbal medicines. Chin J Dermato Vennerol Integr Tradit West Med (Chin) 2005;4(4):240–241.Google Scholar
  4. 4.
    Engin B, Oguz O. Evaluation of time-dependent response to psoralen plus UVA (PUVA) treatment with topical 8-methoxypsoralen (8-MOP) gel in palmoplantar dermatoses. Int J Dermatol 2005;44:337–339.PubMedCrossRefGoogle Scholar
  5. 5.
    Wang DY, Zhang R, Liu P, et al. Observation on the efficacy of treatment using compound glycyrrhizin injection on psoriasis vulgaris and eczema dermatitis. J Pract Med (Chin) 2001;21(15):1690–1691.Google Scholar
  6. 6.
    Wu SX, Guo NR. Clinical observation on effect of triptolide tablet in treating patients with psoriasis vulgaris. Chin J Integr Med 2005;11(2):147–148.PubMedGoogle Scholar
  7. 7.
    Deng AM, Zhong RQ, Chen SX, et al. Lymphocytes in patients with psoriasis promote proliferation of keratinocytes. J Med Coll PLA (Chin) 2002;17(1): 51–53.Google Scholar
  8. 8.
    Arican O, Aral M, Sasmaz S, et al. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 2005; 2005:273–279.PubMedCrossRefGoogle Scholar
  9. 9.
    Chen H, Wang SP. Observation on the efficacy of treatment using Fufang Qingdai Jiaonang on psoriasis vulgaris and serum levels of IL-2, IL-8. J Chin Med Materials (Chin) 2004;27(11):885–886.Google Scholar
  10. 10.
    Qin XW, Zhen MR, Mu XL, et al. Influence on chemotaxis of polymorhphonuclear leukocytes of patients with psoriasis by Ginkgo biloba extract. J Clin Dermatol 1998;27(6):154.Google Scholar
  11. 11.
    Zhang JL, Cheng XR, Yin JZ. Study on apoptosis induced by oxymatrin in cultured keratinocytes. Clin J Derm Vernereol (Chin) 2000;4(6):367.Google Scholar
  12. 12.
    Wang H, Sun LY, Deng BS, et al. The effects of shikonin and indirubin on apoptosis of cultured keratinocytes. Clin J Lepr Skin Dis (Chin) 2003;19(4): 336–338.Google Scholar
  13. 13.
    Werner S, Smola H. Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol 2001;11:143–146.PubMedCrossRefGoogle Scholar
  14. 14.
    Miura H, Sano S, Higashiyama M, et al. Involvement of insulin-like growth factor-I in psoriasis as a paracrine growth factor: dermal fibroblasts play a regulatory role in developing psoriatic lesions. Arch Dermatol Res 2000;292: 590–597.PubMedCrossRefGoogle Scholar
  15. 15.
    Wang YN, Bi XL, Gu J, et al. Study on the mechanism of baicalin in psoriasis treatment. Chin J Dermatovenerol Integr Tradit Med (Chin) 2003; 2(4): 209–211.Google Scholar
  16. 16.
    Bi XL, Wang YN, Gu J, et al. Effects of baicalin on expression of inducible nitric oxide synthase in cultured fibroblasts. Chin J Dermatovenerol Integr Tradit Med (Chin) 2003;2(3):152–154.Google Scholar
  17. 17.
    Jiang WY, Raychaudhuri SP, Farber EM. Double-labeled immunofluorescence study of cutaneous nerves in psoriasis. Int J Dermatol 1998;37:572–574.PubMedCrossRefGoogle Scholar
  18. 18.
    He YL, Ding GF, Hou LF, et al. Expression and secretion of calcitonin gene-related peptide in psoriasis plaque lesions. J Clin Dermatol (Chin) 2000;29:195–197.Google Scholar
  19. 19.
    Qian F, Yang ZB, Ou YH. The effect of Zhuhuang Granules II on related peptide of calcitonin gene. Hunan Guiding J Tradit Chin Med Pharmacol (Chin) 2004;10(12):54–55, 59.Google Scholar
  20. 20.
    Qiu ZQ, Wang XM, Wei XB. Influence of administration of compound Radix Euphorbiae fischerianae injection on cavy’s psoriasis-like animal model. J Chin Clin Med (Chin) 2003;4(10):32–33.Google Scholar
  21. 21.
    Song R, Yuan JM, Wang YY. Study on therapeutic effect of compoundd Radix Sophorae flavecentis injection. Chin J Morden Appl Pharm (Chin) 2002;19(3):177–179.Google Scholar
  22. 22.
    Jin HL, Yu QB, Gao YX. The study of topical administration of artesunate on mice’s psoriasis-like animal model. Chin J Derm Venereol (Chin) 2004;18(11):651–653.Google Scholar
  23. 23.
    Liu MQ. Primary study on growth inhibition of water extracts in different dosage of Radix Arnebiae by vaginal epithelial cells from rat. J Clin Dermatol (Chin) 2003;32(12):714–715.Google Scholar
  24. 24.
    Liu XM, Qi X, Song ZQ, et al. Clinical and experimental observation on treatment of psoriasis with Radix Astragli injection. Chin J Dermatol (Chin) 2001;34(2):113–114.Google Scholar
  25. 25.
    Liu XM, Sun XK, Qi X, et al. Influence of 20 traditional Chinese herbs fed via gantric tube on mouse epithelial mitosis, epidermal cells differentiation and levels of ET-1. Chin J Dermatol (Chin) 2001;34(4):280–283.Google Scholar
  26. 26.
    Xiao QL, Si BH, Wu KZ, et al. Changes of Danshen glucose injection in different dosage on hemorrheology levels of psoriasis. Chin J Dermatol (Chin) 2000;33(6):414–415.Google Scholar
  27. 27.
    Li YX, Zhou QY, Wang JX, et al. Effect of Radix Astragli injection combination with vitaminate in acne on nail wall microcirculation. Chin J Derm Venereol (Chin) 1998;12(6):345–346.Google Scholar
  28. 28.
    Qiu S, Tan SS, Sun ZP. Clinic study of the efficiency of Huoxue Sanyu Xiaoyin Tang in treating psoriasis of the blood-stasis type. J Chin Med Materials (Chin) 2005;28(5):442–444.Google Scholar
  29. 29.
    Xiao QL, Chang KQ, Si BH, et al. Clinic study of the efficiency of different types of YinFuXin in treating vulgar psoriasis. Tianjin J Tradit Chin Med (Chin) 2000;17(2):20–22.Google Scholar
  30. 30.
    Zhou L, Cai NN, Tao Y, et al. Effect of Jiedu Sanyu Tang in the treating psoriasis of the blood-stasis type on the levels of serum lipid concentrations and apolipoprotein. China J Tradit Chin Med Pharm (Chin) 2000;16(3):35–36.Google Scholar

Copyright information

© Chinese Association of Integration of Traditional and Western Medicine 2007

Authors and Affiliations

  1. 1.Department of Dermatology, Changhai Hospitalthe Second Military Medical UniversityShanghaiChina

Personalised recommendations