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Le cellule staminali: impiego clinico

The clinical application of MSCs in orthopaedics

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LO SCALPELLO-OTODI Educational

Abstract

A systematic review of clinical applications of MSCs in the treatment of knee osteoarthritis (OA). Twenty-three papers were included in the final analysis (10 on BMAC and 13 on SVF). Of these, only 4 were randomised controlled trials (RCTs). The Coleman Score, used for bias risk evaluation, revealed an overall poor quality of the studies. In terms of clinical application, despite the apparent safety and the short-term positive clinical outcomes, clinicians reported different preparation and administration methods. The available literature is not sufficient to make any recommendation on the use of either product in clinical practice, even though they have both shown to be safe and have some short-term beneficial effects.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Humanitas University, Rozzano (MI), Italia

    F. Vandenbulcke, G. Beltrame, N. D. Vitale, B. Di Matteo & E. Kon

  2. Humanitas Clinical and Research Center, Rozzano (MI), Italia

    F. Vandenbulcke, N. D. Vitale, B. Di Matteo & E. Kon

  3. First Moscow State Medical University – Sechenov University, Mosca, Russia

    E. Kon

Authors
  1. F. Vandenbulcke
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  2. G. Beltrame
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  3. N. D. Vitale
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  4. B. Di Matteo
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  5. E. Kon
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Correspondence to F. Vandenbulcke.

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Conflitto di interesse

Gli autori F. Vandenbulcke, G. Beltrame, N.D. Vitale, B. Di Matteo e E. Kon dichiarano di non avere alcun conflitto di interesse.

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Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

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L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.

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Vandenbulcke, F., Beltrame, G., Vitale, N.D. et al. Le cellule staminali: impiego clinico. LO SCALPELLO 33, 237–242 (2019). https://doi.org/10.1007/s11639-019-00345-9

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  • DOI: https://doi.org/10.1007/s11639-019-00345-9

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