, Volume 33, Issue 3, pp 289–296 | Cite as

Trattamento delle lesioni ossee traumatiche con le BMPs: revisione della letteratura

  • Jacopo Tamini
  • Biagio Tangredi
  • Michael Mazzacane
  • Roberto Marin
  • Federico Fazzari
  • Placido Stissi
  • Davide Pin
  • Giorgio Zappalà
  • Nicolò Castelnuovo
  • Mario RongaEmail author

Treatment of traumatic bone injuries with BMPs: a review of the literature


The treatment of open fractures and fracture non-unions is a challenging situation for the orthopaedic surgeon. The use of bone morphogenetic proteins (BMPs) in the treatment of these injuries has been assessed by several authors. Indicated for the treatment of open tibial fractures treated with intramedullary fixation and for the treatment of tibial long-bone non-union, BMPs nowadays have been tested in other anatomical sites. Although the clinical efficacy in these cases has not been demonstrated definitely, the use of BMPs has also been considered on the basis of its high cost. This review summarises the evidence present in the literature on BMPs for the treatment of open fractures and non-unions.


Conflitto di interesse

Gli autori Jacopo Tamini, Biagio Tangredi, Michael Mazzacane, Roberto Marin, Federico Fazzari, Placido Stissi, Davide Pin, Giorgio Zappalà, Nicolò Castelnuovo, Ronga Mario dichiarano di non avere alcun conflitto di interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and Animal Rights

L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.


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Copyright information

© Società Italiana Ortopedici Traumatologi Ospedalieri d’Italia 2019

Authors and Affiliations

  • Jacopo Tamini
    • 1
    • 2
  • Biagio Tangredi
    • 3
  • Michael Mazzacane
    • 2
  • Roberto Marin
    • 2
  • Federico Fazzari
    • 2
  • Placido Stissi
    • 2
  • Davide Pin
    • 2
  • Giorgio Zappalà
    • 4
  • Nicolò Castelnuovo
    • 5
  • Mario Ronga
    • 3
    Email author
  1. 1.U.O. Clinica Ortopedica CTO, Azienda Socio Sanitaria Territoriale Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTOUniversità degli Studi di MilanoMilanoItalia
  2. 2.Dipartimento di Biotecnologie e Scienze della Vita (DBSV)Università degli Studi dell’InsubriaVareseItalia
  3. 3.Dipartimento di Medicina e di Scienze della Salute ‘Vincenzo Tiberio’Università degli Studi del MoliseCampobasssoItalia
  4. 4.Dipartimento di Ortopedia e TraumatologiaAzienda Ospedaliera Papa Giovanni XXIII BergamoBergamoItalia
  5. 5.U.O. Ortopedia e TraumatologiaIstituto Clinico Città Studi di MilanoMilanoItalia

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