Identification of TSS in the human genome based on a RBF neural network

  • Zhi-Hong PengEmail author
  • Jie Chen
  • Li-Jun Cao
  • Ting-Ting Gao


The identification of functional motifs in a DNA sequence is fundamentally a statistical pattern recognition problem. This paper introduces a new algorithm for the recognition of functional transcription start sites (TSSs) in human genome sequences, in which a RBF neural network is adopted, and an improved heuristic method for a 5-tuple feature viable construction, is proposed and implemented in two RBFPromoter and ImpRBFPromoter packages developed in Visual C++ 6.0. The algorithm is evaluated on several different test sequence sets. Compared with several other promoter recognition programs, this algorithm is proved to be more flexible, with stronger learning ability and higher accuracy.


Promoter recognition human genome transcription start site RBF neural network 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Roderic Guigo. Computational gene identification: an open problem. Computers Chem, vol. 21, no. 4, pp. 215–222, 1997.CrossRefGoogle Scholar
  2. [2]
    James W. Fickett. The gene identification problem: an overview for developers. Computers Chem, vol. 20, no. 1, pp. 103–118, 1996.CrossRefGoogle Scholar
  3. [3]
    Anders Gorm Pedersen, Pierre Baldi, Y. Chauvin. The biology of eukaryotic promoter prediction — a review. Computers & Chemistry, vol. 23, no. 6, pp. 191–207, 1999.CrossRefGoogle Scholar
  4. [4]
    Uwe Ohler, Heinrich Niemann. Identification and analysis of eukaryotic promoters: recent computational approaches. Trends in Genetics, vol. 17, no. 2, pp. 56–60, 2001.CrossRefGoogle Scholar
  5. [5]
    James W. Fickett, Artemis G. Hatzigeorgiou. Eukaryotic Promoter Recognition. Genome Research, vol. 7, no. 9, pp. 861–878, 1997.Google Scholar
  6. [6]
    Tao Jiang, Ying Xu, Michael Q. Zhang. Current Topics in Computational Molecular Biology. Tsinghua University press, Beijing, pp. 101–255, 2002.Google Scholar
  7. [7]
    G. B. Hutchinson. The prediction of vertebrate promoter regions using differential hexamer frequency analysis. Bioinformatics, vol. 12, no, 5, pp. 391–398, 1996.Google Scholar
  8. [8]
    Michael Q. Zhang. Identification of Human Gene Core Promoters in Silico, Genome Research, vol. 8, pp. 319–326, 1997.Google Scholar
  9. [9]
    Zhaoqi Bian. Pattern recognition, Tsinghua University Press, second edit, Beijing, pp. 250–270, 2000.Google Scholar

Copyright information

© Institute of Automation, Chinese Academy of Sciences 2006

Authors and Affiliations

  • Zhi-Hong Peng
    • 1
    Email author
  • Jie Chen
    • 1
  • Li-Jun Cao
    • 1
  • Ting-Ting Gao
    • 1
  1. 1.College of Information Science and TechnologyBeijing Institute of TechnologyBeijingPRC

Personalised recommendations