Transplantation of umbilical cord–derived mesenchymal stem cells on a collagen scaffold improves ovarian function in a premature ovarian failure model of mice
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Premature ovarian failure (POF) is a refractory disease; one of the most important goals of treatment is to improve fertility. In the study, collagen scaffold loaded with human umbilical cord–derived mesenchymal stem cells (collagen/UC-MSCs) transplantation in POF mice preserved ovarian function, as supported by increased estrogen (E2) and anti-Mullerian hormone (AMH) levels, increased ovarian volume, and an increased number of antral follicles. Immunohistochemistry results of Ki67 indicated transplantation of collagen/UC-MSCs promoted granulosa cell proliferation, which is crucial to oocyte maturation and follicular development. Additionally, transplantation of collagen/UC-MSCs significantly promoted ovarian angiogenesis with the increased expression of CD31. In general, collagen/UC-MSCs transplantation probably is an effective therapeutic strategy of POF.
KeywordsUC-MSCs Collagen scaffold POF Ovarian function
Haixiang Sun is supported by National Nature Science Foundation of China (31571189), Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01030501), Jiangsu Province Social Development Project (BE2018602). This work is also supported from Lijun Ding by grants National Key Research and Development Program of China (2018YFC1004700), National Nature Science Foundation of China (81871128, 81571391, 30900847), Nanjing Medical Science Development Project (JQX14004, ZKX16042), and Jiangsu Provincial Medical Youth Talent (QNRC2016006). Shanshan Wang is supported by National Nature Science Foundation of China (81601277).
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Conflict of interests
The authors declare that they have no conflict of interest.
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