The generation of GLP-grade human embryonic stem cell banks from four clinical-grade cell lines for preclinical research

  • Shirani Sivarajah
  • Grace Selva Raj
  • Adam Joshua Varughese Mathews
  • Norliza Binte Esmail Sahib
  • Wei Sek Hwang
  • Jeremy Micah Crook
Article

Abstract

The Singapore Stem Cell Bank has generated human embryonic stem cell banks from clinical-grade cell lines ESI-017, ESI-035, ESI-049, and ESI-053. All banks were prepared and characterized according to principles of Good Laboratory Practice for quality assurance. Importantly, each cell line has clearly documented and approved ethical provenance and meets recognized standards for performance and safety. The banks are intended to facilitate the translation of stem cell research to clinical medicine by enabling early phase research and development with high-quality, low-cost cells that are also available as clinical-grade stocks.

Keywords

Human embryonic stem cells Good laboratory practice Banks Clinical grade Research grade 

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Copyright information

© The Society for In Vitro Biology 2010

Authors and Affiliations

  • Shirani Sivarajah
    • 1
    • 5
  • Grace Selva Raj
    • 1
  • Adam Joshua Varughese Mathews
    • 1
  • Norliza Binte Esmail Sahib
    • 1
  • Wei Sek Hwang
    • 3
  • Jeremy Micah Crook
    • 1
    • 2
    • 4
  1. 1.Singapore Stem Cell Bank, Singapore Stem Cell Consortium, A*STARSingaporeSingapore
  2. 2.Stem Cell Disease Models Laboratory, Institute of Medical Biology, A*STARSingaporeSingapore
  3. 3.Histopathology, Kandang Kerbau HospitalSingaporeSingapore
  4. 4.Stem Cell Medicine, O’Brien InstituteMelbourneAustralia
  5. 5.Cytentia - Australian Stem Cell BankMelbourneAustralia

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