Regional Trends in Mortality from Alcohol-Induced Causes in the United States, 2000–2017

  • George CholankerilEmail author
  • Brittany B. Dennis
  • Donghee Kim
  • Aijaz Ahmed
Concise Research Report


In the United States (US), alcohol use disorder remains a major contributor to all-cause morbidity with a persistent uptrend in deaths from alcohol-induced causes.1, 2 While recent guidelines from the US Preventative Services Task Force have recommended screening for all adults in the primary care setting,3 understanding the regional disparities and associated sociodemographic factors that may impact the mortality from alcohol-induced causes can aid in prioritizing allocation of resources to at-risk subpopulations.


Using data obtained from the National Center for Health Statistics, we performed a cross-sectional study analyzing all deaths attributable to alcohol-induced causes as defined by the Center of Disease Control by US Census region (Northeast, Midwest, South, and West) and state from 2000 through 2017.4Age-adjusted death rates (per 100,000 persons) for overall and population-specific cohorts were calculated for each US region and state using annual data...


Author Contributions

Dr. Cholankeril was involved in study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, and study supervision. Dr. Dennis, Dr. Kim, and Dr. Ahmed were involved in interpretation of data, drafting of the manuscript, and critical revision of the manuscript for important intellectual content.

Funding Information

Dr. Cholankeril is supported by NIH Training Grant T32DK007056. None of the authors received financial or material support for the research and work in this manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they do not have a conflict of interest.


  1. 1.
    Grant BF, Chou SP, Saha TD, et al. Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry 2017;74(9):911-923.CrossRefGoogle Scholar
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    Kim D, Li AA, Gadiparthi C, et al. Changing Trends in Etiology-Based Annual Mortality From Chronic Liver Disease, From 2007 Through 2016. Gastroenterology. 2018;155(4):1154-1163 e1153.CrossRefGoogle Scholar
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    Curry SJ, Krist AH, et al. Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;320(18):1899-1909.CrossRefGoogle Scholar
  4. 4.
    Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2017 on CDC WONDER Online Database, released December 2018. Data are from the Multiple Cause of Death Files, 1999-2017, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed at on Jul 25, 2019.

Copyright information

© Society of General Internal Medicine 2019

Authors and Affiliations

  1. 1.Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordUSA
  2. 2.Department of Health Research and Policy, Division of EpidemiologyStanford University School of MedicineStanfordUSA
  3. 3.Department of MedicineMcMaster UniversityHamiltonCanada

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