Acute Cardiovascular Effects of Marijuana Use

  • Mehrnaz GhasemiesfeEmail author
  • Divya Ravi
  • Thomas Casino
  • Deborah Korenstein
  • Salomeh Keyhani
Concise Research Report


One out of 7 adults used marijuana in 2017.1 The concentration of tetrahydrocannabinol (THC), the primary psychoactive component of marijuana is increasing in commercially available products.2 However, there is little safety data available on the acute effects of cannabis outside of its psychoactive effects. One area of interest is the acute cardiovascular effects of marijuana given the ubiquitous presence of endocannabinoid receptors in the myocardium, coronary endothelium, and vascular endothelial and smooth muscle cells.3 We conducted a systematic review to examine the acute cardiovascular effects of marijuana use.


We searched PubMed, MEDLINE, EMBASE, PsychINFO, and Cochrane Library for all English-language experimental studies examining marijuana use and acute cardiovascular effects between January 1, 1975, and March 31, 2018. Our search using MeSH terms outlined in Figure 1yielded 1791 articles. We exclude articles with less than 20 participants. Two...


Authors’ Contribution

SK had the idea for the study. SK, MG, DR, DK, and TC created the study design. MG and DR collected the data. SK verified the data. MG, DR, DK, and SK analyzed and interpreted the data. SK and MG wrote and revised the manuscript. All authors critically revised the manuscript and approved the final version for submission. SK is the guarantor.

Compliance with Ethical Standards

Conflict of Interest

All authors declare that they have no conflict of interest.

Ethical Approval

Not needed.

Data Sharing

Data set available from corresponding author on request.


The manuscript’s guarantor (SK) affirms that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned have been explained.


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Copyright information

© Society of General Internal Medicine 2019

Authors and Affiliations

  1. 1.Internal Medicine, Advocate Illinois Masonic Medical CenterChicagoUSA
  2. 2.Internal MedicineThe Wright Center for Graduate Medical EducationScrantonUSA
  3. 3.Division of CardiologyUniversity of MichiganAnn ArborUSA
  4. 4.General Internal Medicine ServiceMemorial Sloan Kettering Cancer CenterNew YorkUSA
  5. 5.Department of MedicineWeill Cornell Medical CollegeNew YorkUSA
  6. 6.Northern California Institute of Research and EducationSan Francisco Veterans Affairs Medical CenterSan FranciscoUSA
  7. 7.Department of General Internal MedicineUCSF Division of General Internal MedicineSan FranciscoUSA

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