GABABR-Mediated Paraneoplastic Limbic Encephalitis Due To Thymic Small Cell Carcinoma
We report the case of a 55-year-old male who presented with several weeks of seizures, agitation, progressive confusion, and receptive aphasia. CSF showed a monocytic pleocytosis and tested positive for GABAB receptor autoantibodies. Pathological examination of an excisional mediastinal lymph node biopsy showed thymic small cell carcinoma, supporting a diagnosis of paraneoplastic limbic encephalitis (PLE). PLE is a subtype of limbic encephalitis and is associated with an array of autoantibodies. Neurologic symptoms related to PLE may precede the detection of the primary cancer. Recognition of the constellation of clinical features of limbic encephalitis should prompt initiation of diagnostic testing for this condition as well as evaluation for an underlying malignancy. A review of the literature reveals that this is the first case report of a patient with thymic small cell cancer presenting with PLE.
KEY WORDSparaneoplastic limbic encephalitis thymic small cell carcinoma GABABR antibody
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they do not have a conflict of interest.
Consent for Publication
Informed consent was obtained from the patient’s wife for publication of this case report and any accompanying images.
- 16.Travis W.D., Brambilla E., Muller-Hermelink H.K., Harris CC, eds. World health organization classification of tumours. tathology and genetics of tumours of the lung, pleura, thymus and heart. IARC Press: Lyon; 2004:188–95.Google Scholar
- 17.Fletcher CD. Diagnostic histopathology of tumors, 2nd ed. Vol. 2. Edinburgh: Churchill Livingstone;2000. 1276–1295.Google Scholar