Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China
In recent decades, much effort has been made in China to reduce the burden of cervical cancer.
Our study’s purpose was to examine trends of cervical cancer mortality in each 5-year age group for urban and rural Chinese women, respectively.
Retrospective analysis of cervical cancer mortality from 1987 to 2015 from the World Health Organization Cancer Mortality Database and China Health Statistical Yearbooks.
Trends were examined using annual percent change (APC) and average annual percent change (AAPC) via Joinpoint regression models for each 5-year age group in urban and rural areas, respectively.
In urban China, mortality rate of cervical cancer increased significantly among urban women aged 25–54 years (AAPC 2.12~5.49%), in contrast to a decline trend among urban women older than 60 years (AAPC − 3.61~− 5.35%). In rural China, cervical cancer rates declined in all age groups, but the magnitude was smaller in women aged 30–54 years (AAPC − 0.59~− 2.20%) compared to women older than 55 years (AAPC − 3.06~− 4.33%).
Mortality rate of cervical cancer is rising at an alarming rate in younger women in urban China. Timely intervention is required for these vulnerable populations.
KEY WORDScervical cancer disparity age-specific mortality trend
Min Wei drafted the manuscript; Wei Zhou drafted the manuscript and collected and analyzed data; Yongyi Bi, Hong Wang, and Yu Liu edited and commented the manuscript; and Zhi-Jiang Zhang concepted the study, supervise the research, and edited the manuscript.
The work was financially supported by the National Natural Science Foundation of China (grant number 81641123) and the Fundamental Research Funds for the Central Universities (grant number 2042017kf0193).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they do not have a conflict of interest.
- 2.Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. Lancet Oncol 2017; 18(12): 1579–1589.Google Scholar
- 7.Dong L, Wang MZ, Zhao XL, et al. Human papillomavirus viral load as a useful triage tool for non-16/18 high-risk human papillomavirus positive women: A prospective screening cohort study. Gynecol Oncol 2018; 148(1): 103–110.Google Scholar
- 14.Qi YX, Liu K, Yin J, Li L. Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI. J Cell Biochem 2018; 119(4): 3017–3029.Google Scholar
- 15.Lei H, Gui D, He Y. Short- and long-term outcomes of laparoscopic radical hysterectomy for obese patients with cervical cancer. J BUON 2017; 22: 958–965.Google Scholar
- 19.Women’s health in rural China. Lancet 2009; 374: 358.Google Scholar
- 22.Liu X, Bi Y, Wang H, et al. Different Trends of Mortality from Colorectal Cancer between Age Groups in China: An Age-Period-Cohort and Joinpoint Analysis. Public Health 2018; 166: 45–52.Google Scholar
- 23.Wang L, Yu C, Liu Y, et al. Lung Cancer Mortality Trends in China from 1988 to 2013: New Challenges and Opportunities for the Government. Int J Environ Res Public Health 2016; 13: 1025.Google Scholar