Journal of General Internal Medicine

, Volume 34, Issue 1, pp 15–16 | Cite as

Folic Acid-Containing Dietary Supplement Consumption and Risk of Cardiovascular Diseases in Rheumatoid Arthritis Patients: NHANES 1999–2014

  • Kalyani SonawaneEmail author
  • Jagpreet Chhatwal
  • Ashish A. Deshmukh
Concise Research Reports


The risk of cardiovascular mortality among patients with rheumatoid arthritis (RA) is double than that of the general population.1 Elevated homocysteine level is considered to be one of the possible factors for increased cardiovascular mortality in RA patients.2 Homocysteine elevation is prevalent among RA patients,3 and a persistent increase in homocysteine level has been reported in patients treated with disease-modifying antirheumatic drugs (DMARDs).4 Folic acid (FA) supplementation can lower blood homocysteine levels by 25%5 and reduce the risk of cardiovascular diseases (CVDs) in the general population by nearly 4%.6 Benefits of long-term FA supplementation, if any, in RA patients are not known. The present study examines the association between consumption of FA-containing dietary supplement and the risk of CVDs in RA patients treated with DMARDs.


We used data form the National Health and Nutrition Examination Survey (NHANES) 1999–2014, a complex, stratified,...


arthritis cardiovascular diseases prevention 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they do not have a conflict of interest.


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Copyright information

© Society of General Internal Medicine 2018

Authors and Affiliations

  • Kalyani Sonawane
    • 1
    Email author
  • Jagpreet Chhatwal
    • 2
  • Ashish A. Deshmukh
    • 1
  1. 1.Department of Management, Policy, and Community HealthThe University of Texas Health Science Center at HoustonHoustonUSA
  2. 2.Massachusetts General Hospital Institute for Technology AssessmentHarvard Medical SchoolBostonUSA

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