Application and Impact of Run-In Studies for the Evaluation of Statin Efficacy and Safety
KEY WORDSrun-in statin clinical trial study design
Study concept and design: Fralick M, Kesselheim A, and Avorn J
Acquisition of data: Fralick M, Abdurrob A, and Bartsch E
Analysis/interpretation of data: Fralick M, Kesselheim A, Franklin J, Avorn J, and Bartsch E
Drafting of the manuscript: Fralick M
Critical revision of the manuscript: Kesselheim A, Franklin J, Avorn J, Abdurrob A, and Bartsch E
Statistical analysis: Fralick M and Franklin J
Dr. Fralick receives funding from the Eliot Phillipson Clinician-Scientist Training Program and the Clinician Investigator Program at the University of Toronto and from The Detweiler Travelling Fellowship funded by the Royal College of Physicians and Surgeons of Canada. This study is also funded by The Laura and John Arnold Foundation. Dr. Kesselheim’s work is also supported by the Harvard Program in Therapeutic Science and the Engelberg Foundation.
Compliance with Ethical Standards
Conflict of Interest
Dr. Franklin is the principal investigator on a grant from Merck. All remaining authors declare that they do not have a conflict of interest.