Journal of General Internal Medicine

, Volume 33, Issue 2, pp 216–222 | Cite as

Advancing the Science and Practice of Medication Adherence

  • Michael J. Stirratt
  • Jeffrey R. Curtis
  • Maria I. Danila
  • Richard Hansen
  • Michael J. Miller
  • C. Ann Gakumo


Medication adherence remains a significant unmet challenge for optimizing patient outcomes. Recent advances in the conceptualization, measurement, and support of medication adherence offer fresh opportunities to make a meaningful impact on adherence-related behavior and outcomes. These advances emphasize the multifaceted and dynamic nature of medication adherence, provide novel methods for monitoring medication adherence in clinical care, and articulate a set of multilevel strategies to more effectively improve and sustain medication adherence. Here, we offer recommendations for how clinicians can better engage with, and benefit from, these innovations to improve patient medication adherence and associated treatment outcomes.


adherence persistence adherence interventions adherence measures medication adherence 



Dr. Gakumo is supported by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program 72113. Dr. Danila is supported by NIAMS K23 AR062100. The authors would like to thank the UAB “Interdisciplinary Approaches to Understanding and Improving Adherence” conference leaders, and Elizabeth Rahn, PhD, for their review and input in the preparation of this manuscript, and Stacey C. Tobin, PhD, for providing editorial support. Appreciation is also extended to members of the NIH Adherence Network for input on a related UAB conference presentation.

Compliance with Ethical Standards

Conflict of Interest

Drs. Stirratt, Gakumo, Curtis, Danila, and Miller report no conflict of interest. In the past 3 years, Dr. Hansen has provided expert testimony for Boehringer Ingelheim on unrelated matters.


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Copyright information

© Society of General Internal Medicine 2017

Authors and Affiliations

  • Michael J. Stirratt
    • 1
  • Jeffrey R. Curtis
    • 2
  • Maria I. Danila
    • 2
  • Richard Hansen
    • 3
  • Michael J. Miller
    • 4
  • C. Ann Gakumo
    • 5
  1. 1.Division of AIDS Research National Institute of Mental HealthBethesdaUSA
  2. 2.Division of Clinical Immunology and RheumatologyUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Health Outcomes Research and PolicyAuburn University Harrison School of PharmacyAuburnUSA
  4. 4.Department of Pharmaceutical SciencesTexas A&M University Irma Lerma Rangel College of PharmacyCollege StationUSA
  5. 5.Department of Acute, Chronic & Continuing CareUniversity of Alabama at Birmingham School of NursingBirminghamUSA

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