Purpura Fulminans in Acute Meningococcemia
KEY WORDSPurpura fulminans Acute meningococcemia Critical care medicine
Purpura fulminans (PF) is a severe cutaneous complication of acute meningococcemia. It is characterized by cutaneous hemorrhage and necrosis due to vascular thrombosis of dermis and disseminated intravascular coagulopathy.1 PF is considered an important predictor of poor outcomes following meningococcal infection.1 Acquired severe protein C deficiency in meningococcemia is thought to play an important role in the pathogenesis of PF.2 There are no definitive treatments for PF; however, protein C concentrate, heparin and hemodiafiltration may improve clinical outcome and mortality in patients with acute meningococcemia.2
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