This update in the care of individuals with HIV reviews key research publications from the past year relevant to General Internal Medicine practitioners. Specific topics that we have covered include new developments in the understanding of HIV transmission, risk behavior among injection drug users, baseline resistance testing, choice of initial treatment regimens, and controversies in treatment interruption. Our selection process was based on MEDLINE review of key journals by all authors and recommendations of experts in this field. The original MEDLINE review encompassed January 1, 2005 to March 1, 2006 and has been updated to Sepetember 1, 2006. Key phrases used in the search included “HIV,” “AIDS,” “heterosexuality,” “antiretroviral treatment (ART)/highly active antiretroviral therapy (HAART),” “drug resistance,” and “risk behaviors”.
Epidemiologic studies suggest the risk of HIV infection per heterosexual (coital) encounter (HIV infected to uninfected...
Key wordsHIV AIDS antiretroviral
This paper was presented at the meeting of the society of General Internal Medecine, in May 2006.
Potential Financial Conflicts of Interest
- 3.Wensing AMJ, van de Vijver DA, Angarano G, et al. for the SPREAD Programme. Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. J Infect Dis. September 15, 2005;191(6):958–66. Erratum in: J Infect Dis. 2005;192(8):1501.Google Scholar
- 4.Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. May 4, 2006. Developed by the DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents. Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed July 30, 2006.
- 5.Gallant JE, DeJesus E, Arribas JF et al. for the Study 934 Group. Tenofovir DF, emtricitabine, and efavirenz versus zidovudine, lamivudine, and efavirenz for HIV. N Engl J Med. January 19, 2006;354;3.Google Scholar
- 9.El-Sadr W, Neaton J for the SMART Study Investigators. The SMART Study: Strategies for Management of Antiretroviral Therapy 13th CROI, Denver, CO February 5–8, 2006. Abst. 106LB.Google Scholar
- 10.Daniel C, Moh R, Sorho S, et al. The CD4 guided strategy arm stopped in a randomized structured treatment interruption trial in West African adults: ANRS 1269 Trivacan Trial. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections; February 5–8, 2006; Denver, Colorado. Abstract 105LB.Google Scholar
- 11.Ananworanich J, Gayet-Agernon A, LaBraz M, et al. CD4 guided scheduled treatment interruption compared to continuous therapy: results of the Staccato Trial. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections; February 5–8, 2006; Denver, Colorado. Abstract 102.Google Scholar