Journal of General Internal Medicine

, Volume 16, Issue 2, pp 137–139 | Cite as

Polypharmacy and medication adherence

Small steps on a long road
  • Michael D. Murray
  • Kurt Kroenke


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  1. 1.
    Muir AJ, Sanders LL, Wilkinson WE, Schmader K. Reducing medication regimen complexity: a controlled trial. J Gen Intern Med. 2001;16:77–82.PubMedCrossRefGoogle Scholar
  2. 2.
    Yang JC, Tomlinson G, Naglie G. Medication lists in elderly patients: clinic-derived versus in-home inspection and interview. J Gen Intern Med. 2001;16:112–5.PubMedCrossRefGoogle Scholar
  3. 3.
    Cook RL, Sereika SM, Hunt SC, Woodward WC, Erlen JA, Conigliaro J. Problem drinking and medication adherence among persons with HIV infection. J Gen Intern Med. 2001;16:83–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Beers MH, Dang J, Hasegawa J, Tamai IY. Influence of hospitalization on drug therapy in the elderly. J Am Geriatr Soc. 1989;37:679–83.PubMedGoogle Scholar
  5. 5.
    Omori DM, Potyk RP, Kroenke K. The adverse effects of hospitalization on drug regimens. Arch Intern Med. 1991;151:1562–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Murray MD. Polypharmacy: Management of therapeutic regimens. In: Mezey MD, Bottrell MM, Berkman BJ, et al, eds. The Encyclopedia of Elder Care: The Comprehensive Resource on Geriatric and Social Care. New York: Springer Publishing Company; 2000.Google Scholar
  7. 7.
    Kruse W, Rampmaier J, Frauenrath-Volkers C, et al. Drug-prescribing patterns in old age. Eur J Clin Pharmacol. 1991;41:441–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Gerety MB, Cornell JE, Plichta DT, Eimer M. Adverse events related to drugs and drug withdrawal in nursing home residents. J Am Geriatr Soc. 1993;41:1326–32.PubMedGoogle Scholar
  9. 9.
    Graves T, Hanlon JT, Schmader KE, et al. Adverse events after discontinuing medications in elderly outpatients. Arch Intern Med. 1997;157:2205–10.PubMedCrossRefGoogle Scholar
  10. 10.
    Smith DM, Cox MR, Brizendine EJ, et al. An intervention on discharge polypharmacy. J Am Geriatr Soc. 1996;44:416–9.PubMedGoogle Scholar
  11. 11.
    Hanlon JT, Fillenbaum GG, Studenski SA, Ziqubu-Page T, Wall WE. Factors associated with suboptimal analgesic use in community-dwelling elderly. Ann Pharmacother. 1996;30:739–44.PubMedGoogle Scholar
  12. 12.
    Kernan WN, Viscoli CM, Brass LM, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med. 2000;343:1826–32.PubMedCrossRefGoogle Scholar
  13. 13.
    Fugh-Berman A. Herb-drug interactions. Lancet. 2000;355:134–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Gonski PN, Strathers GM, Freiman JS, Smith T. A critical review of admission and discharge medications in an elderly Australian population. Drugs and Aging. 1993;3:358–62.PubMedGoogle Scholar
  15. 15.
    Park DC, Jones TR. Medication adherence and aging. In: Fisk AD, Rogers WA, eds. Handbook of Human Factors and the Older Adult. 1st ed. New York: Academic Press; 1997:257–87.Google Scholar
  16. 16.
    Vanhove GF, Schapiro JM, Winters MA, Merigan TC, Blaschke TF. Patient compliance and drug failure in protease inhibitor monotherapy. JAMA. 1996;276:1955–6.PubMedCrossRefGoogle Scholar
  17. 17.
    Kroenke K. Polypharmacy: causes, consequences, and cure. Am J Med. 1985;79:149–52.PubMedCrossRefGoogle Scholar

Copyright information

© Blackwell Science Inc 2001

Authors and Affiliations

  • Michael D. Murray
    • 1
  • Kurt Kroenke
    • 2
  1. 1.Department of Pharmacy PracticePurdue University School of Pharmacy, Regenstrief Institute for Health CareIndianapolis
  2. 2.Regenstrief Institute for Health Care, Indianapolis Ind., and Department of MedicineIndiana University School of MedicineBloomington

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