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Role of Adjuvant Chemotherapy in Resected T2N0 Gall Bladder Cancer

  • Abhay K. Kattepur
  • Shraddha PatkarEmail author
  • Mahesh Goel
  • Anant Ramaswamy
  • Vikas Ostwal
Original Article
  • 9 Downloads

Abstract

Background

Management of operable gall bladder cancer (GBC) is closely related to its tumor (T) and nodal (N) status. The magnitude of benefit with adjuvant chemotherapy in completely resected, node negative T2 cancers is not completely defined.

Materials and Methods

Retrospective analysis of patients diagnosed with pathological T2N0 (stage II, 7th edition AJCC) GBCs from January 2011 to June 2016 was evaluated for adverse risk factors, adjuvant treatment received, recurrence-free survival (RFS), and overall survival (OS). Survival analysis was done using Kaplan-Meier and Cox regression tools.

Results

Of the 88 patients included, 30 received adjuvant chemotherapy while 58 were observed. The OS and RFS in the entire cohort were 82.9% and 62.7%, respectively, at a median follow-up of 44.18 months. The OS and RFS in the chemotherapy group were 85.1% and 76.4% while it was 81.4% and 55.5% in the observation group (p = 0.50). Recurrent disease was seen in 30.7%.The presence of lymphovascular invasion predicted inferior RFS (p = 0.031).

Conclusions

Adjuvant chemotherapy may reduce distant failure rates but did not improve OS in completely resected T2N0 GBC patients in this study. LVI predicted inferior RFS in T2N0 patients. An evaluation of adverse prognostic factors would help design personalized treatment strategies for this select cohort of T2N0 GBC.

Keywords

Gall bladder cancer Adjuvant chemotherapy T2N0 Lymphovascular invasion (LVI) 

Notes

Authors’ Contribution

AKK and SP have contributed equally towards concept, design, data collection and analysis, interpretation and final approval of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2019

Authors and Affiliations

  1. 1.Gastrointestinal Oncology services, Department of Surgical OncologyTata Memorial HospitalMumbaiIndia
  2. 2.Gastrointestinal Oncology services, Department of Medical OncologyTata Memorial HospitalMumbaiIndia

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