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Clinicopathological Outcomes and Prognosis of Elderly Patients (≥ 65 Years) with Gastric Gastrointestinal Stromal Tumors (GISTs) Undergoing Curative-Intent Resection: a Multicenter Data Review

  • Zifeng Yang
  • Xingyu Feng
  • Peng Zhang
  • Tao Chen
  • Haibo Qiu
  • Yongjian Zhou
  • Chunyan Du
  • Xiaonan Yin
  • Fang Pan
  • Guoliang Zheng
  • Xiufeng Liu
  • Changming Huang
  • Zhiwei Zhou
  • Guoxin Li
  • Kaixiong TaoEmail author
  • Yong LiEmail author
Original Article
  • 129 Downloads

Abstract

Background

The most common site of gastrointestinal stromal tumors (GISTs) is the stomach, and gastric GISTs (gGISTs) occur most often in elderly patients. However, the clinicopathological features, treatment patterns, and prognosis of elderly patients with gGISTs remain unclear.

Methods

We retrospectively collected clinicopathological and prognostic data for patients with primary gGISTs who underwent curative-intent resection at 10 medical centers in China from 1998 to 2015.

Results

Over the 18 years, 10 medical centers treated 1846 patients with primary gGISTs by curative-intent resection. The median age was 59 (range 18–91) years. The patients were classified into two groups according to age, namely an elderly group (≥ 65 years of age) and a nonelderly group (< 65 years of age). The elderly group had more comorbidities (40.7% vs 23.5%, p = 0.011), a higher rate of postoperative complications (14.4% vs 8.7%, p = 0.031), and a lower proportion of intermediate/high-risk patients who received adjuvant therapy (30.0% vs 66.8%, p = 0.001) than did the nonelderly group. Regarding pathological outcomes, a significant difference in tumor necrosis was observed between the two groups (p = 0.002), and more cases of tumor necrosis occurred in the elderly group than in the nonelderly group. Regarding postoperative recovery outcomes, no significant difference was observed between the two groups. Univariate analysis showed that age, postoperative complications, adjuvant therapy, tumor size, mitotic count, modified National Institutes of Health (NIH) risk category, and tumor necrosis were factors that affected disease-free survival (DFS). Multivariate analysis showed that modified NIH risk category was the only independent factor affecting DFS. The 5-year DFS rates in the nonelderly and elderly groups were 88.1% and 81.4%, respectively (p = 0.034), and the 5-year overall survival (OS) rates were 90.4% and 85.5% (p = 0.038), respectively.

Conclusions

Currently, the treatment patterns for elderly patients with gGISTs remain the same as those for young patients with gGISTs. Elderly gGIST patients had more comorbidities and postoperative complications than did nonelderly gGIST patients, and fewer elderly gGIST patients received postoperative adjuvant therapy. Elderly gGIST patients also had a higher rate of tumor necrosis and worse DFS and OS than did young gGIST patients. Further exploration into the diagnosis and treatment patterns of elderly patients is therefore essential.

Keywords

Clinicopathological outcomes Prognosis Gastric GIST Elderly patients 

Notes

Acknowledgments

Dr. Zifeng Yang would like to acknowledge the support and guidance received from his postgraduate mentor, Prof. Li Yong, in the past 4 years. In addition, he would also like to thank Lianye Zhang for the constant patience, care, and love.

Author Contributions

All authors listed above have made substantial contributions to the conception and design of this study, have revised its intellectual content, and have approved the final submitted version of the manuscript.

Funding

This study was supported by the Natural Science Foundation of Guangdong Province (2016A030310328) and Medical Scientific Research Foundation of Guangdong Province, People’s Republic of China (A2016228).

Compliance with Ethical Standards

We received ethics approval for this case series from 10 medical centers in China (Guangdong General Hospital; Guangdong Academy of Medical Science, Guangzhou, People’s Republic of China; Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, People’s Republic of China; Southern Medical University Nanfang Hospital, Guangzhou, People’s Republic of China; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China; Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; West China Hospital, Sichuan University, Chengdu, People’s Republic of China; Peking University Cancer Hospital and Institute, Beijing, People’s Republic of China; Liaoning Cancer Hospital and Institute, Shenyang, People’s Republic of China; People’s Liberation Army Cancer Center; 81st Hospital of PLA, Nanjing, People’s Republic of China).

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2018

Authors and Affiliations

  1. 1.Department of General Surgery, Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouPeople’s Republic of China
  2. 2.Department of General SurgeryUnion Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanPeople’s Republic of China
  3. 3.Department of General Surgery, Nanfang HospitalSouthern Medical UniversityGuangzhouPeople’s Republic of China
  4. 4.Department of Gastric and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouPeople’s Republic of China
  5. 5.Department of Gastric SurgeryFujian Medical University Union HospitalFuzhouPeople’s Republic of China
  6. 6.Department of Gastric and Soft Tissue SurgeryFudan University Shanghai Cancer CenterShanghaiPeople’s Republic of China
  7. 7.Department of Gastrointestinal Surgery, West China HospitalSichuan UniversityChengduPeople’s Republic of China
  8. 8.Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingPeople’s Republic of China
  9. 9.Department of Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangPeople’s Republic of China
  10. 10.Department of Oncology, People’s Liberation Army (PLA) Cancer Center81st Hospital of PLANanjingPeople’s Republic of China

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