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Journal of Gastrointestinal Surgery

, Volume 23, Issue 2, pp 270–279 | Cite as

Clinicopathologic Characteristics and Optimal Surgical Treatment of Duodenal Gastrointestinal Stromal Tumor

  • Seung Jae Lee
  • Ki Byung SongEmail author
  • Young-Joo Lee
  • Song Cheol Kim
  • Dae Wook Hwang
  • Jae Hoon Lee
  • Sang Hyun Shin
  • Jae Woo Kwon
  • Seung Hyun Hwang
  • Chung Hyeun Ma
  • Gui Suk Park
  • Ye Jong Park
  • Kwang-Min Park
Original Article
  • 233 Downloads

Abstract

Background

The clinicopathologic characteristics of duodenal gastrointestinal stromal tumor (GIST) were unclear and the optimal surgical procedure for duodenal GIST remains poorly defined. We aimed to analyze clinicopathological characteristics, survival outcomes based on the surgical procedure, and recommend optimal surgical treatment for duodenal GIST.

Methods

From July 2000 to April 2017, 118 patients with localized duodenal GIST underwent curative surgical resection at a single institution. We retrospectively reviewed the clinicopathological characteristics and survival outcomes.

Results

The 5-year overall survival (OS) and disease-free survival (DFS) rates were 94.9 and 79.2%, respectively. On multivariate analysis, the mitotic count was a statistically significant prognostic factor for DFS. Limited resection (LR) was performed in 20 patients with GIST in the first or fourth portion of the duodenum. Both LR and pancreaticoduodenectomy (PD) were performed in 98 patients with GIST in second or third portion of the duodenum. The patients in the LR group had less late complications than in the PD group and no postoperative newly developed diabetes mellitus. The minimally invasive LR (MI-LR) group had a shorter duration of surgery and shorter length of postoperative hospital stay.

Conclusion

LR is a feasible and effective surgical treatment for patients with small-sized and antimesenteric-sided duodenal GIST in terms of late complications and postoperative diabetic complications. MI-LR has better perioperative outcomes than open LR. Therefore, we should consider MI-LR as an optimal surgical treatment for selected patients with duodenal GIST.

Keywords

Duodenum Gastrointestinal stromal tumor Limited resection Pancreaticoduodenectomy Minimally invasive surgery 

Notes

Author’s Contributions

Substantial contributions to the conception or design of the work, or the acquisition, analysis, or interpretation of data for the work were done by Seung Jae Lee, Ki Byung Song, Young-Joo Lee, Song Cheol Kim, Dae Wook Hwang, Jae Hoon Lee, Sang Hyun Shin, Jae Woo Kwon, Seung Hyun Hwang, Chung Hyeun Ma, Gui Suk Park, Ye Jong Park, and Kwang-Min Park. Drafting the work or revising it critically for important intellectual content was done by Seung Jae Lee and Ki Byung Song. Final approval of the version to be published was done by Seung Jae Lee and Ki Byung Song. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved was done by Seung Jae Lee and Ki Byung Song.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2018

Authors and Affiliations

  • Seung Jae Lee
    • 1
  • Ki Byung Song
    • 1
    Email author
  • Young-Joo Lee
    • 1
  • Song Cheol Kim
    • 1
  • Dae Wook Hwang
    • 1
  • Jae Hoon Lee
    • 1
  • Sang Hyun Shin
    • 1
  • Jae Woo Kwon
    • 1
  • Seung Hyun Hwang
    • 1
  • Chung Hyeun Ma
    • 1
  • Gui Suk Park
    • 1
  • Ye Jong Park
    • 1
  • Kwang-Min Park
    • 1
  1. 1.Division of Hepatobiliary and Pancreatic Surgery, Department of SurgeryUniversity of Ulsan College of Medicine and Asan Medical CenterSeoulSouth Korea

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