Comparison of Hepatectomy for Patients with Metabolic Syndrome-Related HCC and HBV-Related HCC
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Metabolic syndrome (MetS) is a group of clinicopathological manifestations. The outcome of liver surgery in metabolic syndrome-related hepatocellular carcinoma (MetS-HCC) still needs to be evaluated. We aim to clarify the outcomes following liver resection in patients with MetS-HCC compared those with hepatitis B virus-related HCC (HBV-HCC).
All the consecutive patients undergoing hepatectomy for HCC between January 2009 and December 2012 were retrospectively considered. Patients were divided into three groups: MetS-HCC, MetS-HBV-HCC, and HBV-HCC. Data on clinical characteristics, postoperative complications, and long-term outcome were collected and analyzed.
A total of 1352 patients were included in this study. In MetS-HCC group, the severe morbidity rate was 33.33%, which was higher than that of HBV-HCC group (15.68%). In subgroup analysis, patients with MetS-HCC in American Joint Committee on Cancer (AJCC) stage I had superior DFS and OS when compared with those of the other two groups.
We should pay more attention to patients with MetS-HCC perioperatively due to the high rate of surgical complications. Nevertheless, curative treatment should be provided to patients with MetS.
KeywordsHepatectomy Metabolic syndrome Hepatitis virus B Hepatocellular carcinoma Surgery
Feng Shen and Yunhong Tian designed the research; Feng Shen, Jun Li, and Yong Xia performed the surgery and collected the data; Yunhong Tian, Jun Li, and Huan Lyu contributed to the discussion part. Huan Lyu and Yunhong He analyzed the data; Yunhong Tian wrote the paper.
All authors are in agreement with the contents of the manuscript and confirm that the paper is not being published or under consideration elsewhere.
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