A Novel Nomogram for Predicting Postsurgical Intra-abdominal Infection in Gastric Cancer Patients: a Prospective Study
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This study aimed to determine the relationship between intra-abdominal infection (IAI) and sarcopenia prospectively and to construct a nomogram to identify patients at a high risk of IAI.
We conducted a prospective study of 682 consecutive patients with gastric cancer who underwent radical gastrectomy. The sarcopenia elements, including lumbar skeletal muscle index, handgrip strength, and gait speed, were measured before surgery. Factors contributing to IAI were determined through univariate and multivariate analysis. A nomogram consisting of the independent risk factors was constructed to quantify the individual risk of IAI.
Of the 682 patients enrolled in this study, 132 patients were diagnosed with sarcopenia and 61 were diagnosed with IAI. Logistic analysis revealed that sarcopenia, tumor size, pathological type, and multivisceral resection were independent prognostic factors for IAI. The nomogram model for IAI was able to reliably quantify the risk of IAI with a strong optimism-adjusted discrimination (concordance index, 0.736).
Sarcopenia is an independent predictor of IAI. Our nomogram was a simple and practical instrument to quantify the individual risk of IAI and could be used to identify patients at a high risk.
KeywordsSarcopenia Intra-abdominal infection Nomogram
This work was supported by the National Nature Science Foundation of China (Grant Nos. 31470891, 81001343), Public Projects of Science and Technology Department of Zhejiang province (2014C33140).
Conception or design of the work: XS and GBZ; drafting the work: CCM and XDC; data acquisition: JL, WSZG, and ZDX; data analysis: XYC, FMZ, and RSW; data interpretation: WTZ, NL, and LS; supervision or mentorship: XS and GBZ. All the authors contributed important intellectual content for the overall work. XS and GBZ take responsibility for the honesty and accuracy of the present study.
Compliance with Ethical Standards
The study was approved by the ethics committee of the First Affiliated Hospital of Wenzhou Medical University and conformed to the tenets of the Declaration of Helsinki, and all participants provided written informed consent before participating in the study.
Conflict of Interest
The authors declare that they have no conflict of interests.
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