Journal of Gastrointestinal Surgery

, Volume 20, Issue 12, pp 2035–2051 | Cite as

Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage

  • Sami A. Chadi
  • Abe Fingerhut
  • Mariana Berho
  • Steven R. DeMeester
  • James W. Fleshman
  • Neil H. Hyman
  • David A. Margolin
  • Joseph E. Martz
  • Elisabeth C. McLemore
  • Daniela Molena
  • Martin I. Newman
  • Janice F. Rafferty
  • Bashar Safar
  • Anthony J. Senagore
  • Oded Zmora
  • Steven D. WexnerEmail author


Anastomotic leaks represent one of the most alarming complications following any gastrointestinal anastomosis due to the substantial effects on post-operative morbidity and mortality of the patient with long-lasting effects on the functional and oncologic outcomes. There is a lack of consensus related to the definition of an anastomotic leak, with a variety of options for prevention and management. A number of patient-related and technical risk factors have been found to be associated with the development of an anastomotic leak and have inspired the development of various preventative measures and technologies. The International Multispecialty Anastomotic Leak Global Improvement Exchange group was convened to establish a consensus on the definition of an anastomotic leak as well as to discuss the various diagnostic, preventative, and management measures currently available.


Gastrointestinal anastomotic leakage Review Morbidity International Multispecialty Anastomotic Leak Global Improvement Exchange Consensus 


Compliance with Ethical Standards

NOVADAQ provided funding for travel and and/or honoraria to the IMAGInE consensus group for the development of this document. The lead author was compensated for the preparation of this mansucript. M Berho is a paid consultant for NOVADAQ; S DeMeester is a paid lecturer for NOVADAQ; D Molena is a paid educational presentation developer for NOVADAQ; A Senagore is a paid lecturer for NOVADAQ; SD Wexner is a paid consultant for NOVADAQ and Karl Storz Endoscopy; O Zmora is a paid lecture and lectures and paid educational lecture developer for NOVADAQ.


NOVADAQ Corporation reviewed the final manuscript but did not have any role in the preparation of the manuscript, selection of the speakers, topics, or content of the symposium, and had no editing privileges. NOVADAQ Corporation did not influence the manuscript.

Authorship Contribution

All authors have made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. NOVADAQ Corporation made no contributions to this manuscript.


  1. 1.
    Di Cristofaro L, Ruffolo C, Pinto E, Massa M, Antoniutti M, Cagol M, Massani M, Alfieri R, Costa A, Bassi N, Castoro C, Scarpa M. Complications after surgery for colorectal cancer affect quality of life and surgeon-patient relationship. Colorectal Dis. 2014;16(12):O407–19.PubMedCrossRefGoogle Scholar
  2. 2.
    Turrentine FE, Denlinger CE, Simpson VB, Garwood RA, Guerlain S, Agrawal A, Friel CM, LaPar DJ, Stukenborg GJ, Jones RS. Morbidity, mortality, cost, and survival estimates of gastrointestinal anastomotic leaks. J Am Coll Surg. 2015;220(2):195–206.PubMedCrossRefGoogle Scholar
  3. 3.
    Kassis ES, Kosinski AS, Ross P, Koppes KE, Donahue JM, Daniel VC. Predictors of Anastomotic Leak After Esophagectomy: An Analysis of The Society of Thoracic Surgeons General Thoracic Database. Ann Thorac Surg. 2013;96(6):1919–26.PubMedCrossRefGoogle Scholar
  4. 4.
    Briel JW, Tamhankar AP, Hagen JA, DeMeester SR, Johansson J, Choustoulakis E, Peters JH, Bremner CG, DeMeester TR. Prevalence and risk factors for ischemia, leak, and stricture of esophageal anastomosis: gastric pull-up versus colon interposition. J Am Coll Surg. 2004;198(4):536–41–discussion541–2.Google Scholar
  5. 5.
    Phitayakorn R, Delaney CP, Reynolds HL, Champagne BJ, Heriot AG, Neary P, Senagore AJ, International Anastomotic Leak Study Group. Standardized algorithms for management of anastomotic leaks and related abdominal and pelvic abscesses after colorectal surgery. World J Surg. 2008;32(6):1147–56.PubMedCrossRefGoogle Scholar
  6. 6.
    Ortiz H, Biondo S, Codina A, Ciga MÁ, Enríquez-Navascués J, Espin E, Garcia-Granero E, Roig JV. Hospital variation in anastomotic leakage after rectal cancer surgery in the Spanish Association of Surgeons project: The contribution of hospital volume. Cir Esp. 2016;94(4):213–20.PubMedCrossRefGoogle Scholar
  7. 7.
    Markar S, Gronnier C, Duhamel A, Bigourdan J-M, Badic B, Rieu du MC, Lefevre JH, Turner K, Luc G, Mariette C. Pattern of Postoperative Mortality After Esophageal Cancer Resection According to Center Volume: Results from a Large European Multicenter Study. Ann Surg Oncol. 2015;22(8):2615–23.Google Scholar
  8. 8.
    Hyman NH, Osler T, Cataldo P, Burns EH, Shackford SR. Anastomotic Leaks after Bowel Resection: What Does Peer Review Teach Us about the Relationship to Postoperative Mortality? J Am Coll Surg. 2009;208(1):48–52.PubMedCrossRefGoogle Scholar
  9. 9.
    Peel AL, Taylor EW. Proposed definitions for the audit of postoperative infection: a discussion paper. Surgical Infection Study Group. Ann R Coll Surg Engl.1991;73(6):385-8.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Bruce J, Krukowski ZH, Al-Khairy G, Russell EM, Park KG. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg. 2001;88(9):1157–68.PubMedCrossRefGoogle Scholar
  11. 11.
    Paliogiannis P, Attene F, Scognamillo F, Trignano E, Torre C, Pulighe F, Trignano M. Conservative management of minor anastomotic leakage after open elective colorectal surgery. Ann Ital Chir. 2012;83(1):25–8.PubMedGoogle Scholar
  12. 12.
    Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M. Postoperative pancreatic fistula: An international study group (ISGPF) definition. Surgery. 2005;138(1):8–13.PubMedCrossRefGoogle Scholar
  13. 13.
    Rahbari N, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, Holm T, Wong WD, Tiret E, Moriya Y, Laurberg S, Dulk den M, van de Velde C, Büchler M. Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer. Surgery. 2010;147(3):339–51.Google Scholar
  14. 14.
    Kulu Y, Ulrich A, Bruckner T, Contin P, Welsch T, Rahbari N, Büchler M, Weitz J. Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage. Surgery. 2013;153(6):753–61.PubMedCrossRefGoogle Scholar
  15. 15.
    Hammond J, Lim S, Wan Y, Gao X, Patkar A. The Burden of Gastrointestinal Anastomotic Leaks: an Evaluation of Clinical and Economic Outcomes. J Gastrointest Surg. 2014;18(6):1176–85.PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Lundy JB. A primer on wound healing in colorectal surgery in the age of bioprosthetic materials. Clinics in Colon and Rectal Surgery. 2014;27(4):125–33.PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Hawley PR, Faulk WP, Hunt TK, Dunphy JE. Collagenase activity in the gastro-intestinal tract. Br J Surg. 1970;57(12):896–900.PubMedCrossRefGoogle Scholar
  18. 18.
    Schardey HM, Joosten U, Finke U, Staubach KH, Schauer R, Heiss A, Kooistra A, Rau HG, Nibler R, Lüdeling S, Unertl K, Ruckdeschel G, Exner H, Schildberg FW. The prevention of anastomotic leakage after total gastrectomy with local decontamination. A prospective, randomized, double-blind, placebo-controlled multicenter trial. Ann Surg. 1997;225(2):172–80.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Schardey HM, Kamps T, Rau HG, Gatermann S, Baretton G, Schildberg FW. Bacteria: a major pathogenic factor for anastomotic insufficiency. Antimicrob Agents Chemother. 1994;38(11):2564–7.PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K. Do We Really Know Why Colorectal Anastomoses Leak? J Gastrointest Surg. 2013;17(9):1698–707.PubMedCrossRefGoogle Scholar
  21. 21.
    Cohn I, Rives JD. Antibiotic protection of colon anastomoses. Ann Surg. 1955;141(5):707–17.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. 2015;7(286):286ra68–8.Google Scholar
  23. 23.
    Øines MN. Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis. World J Gastroenterol. 2014;20(35):12637–13.PubMedPubMedCentralCrossRefGoogle Scholar
  24. 24.
    Rolandelli RH, Buckmire MA, Bernstein KA. Intravenous butyrate and healing of colonic anastomoses in the rat. Dis Colon Rectum.1997;40(1):67–70.PubMedCrossRefGoogle Scholar
  25. 25.
    Mathew AJ, Wann VC, Abraham DT, Jacob PM, Selvan BS, Ramakrishna BS, Nair AN. The effect of butyrate on the healing of colonic anastomoses in rats. J Invest Surg. 2010;23(2):101–4.PubMedCrossRefGoogle Scholar
  26. 26.
    Bloemen JG, Schreinemacher MH, de Bruine AP, Buurman WA, Bouvy ND, Dejong CH. Butyrate enemas improve intestinal anastomotic strength in a rat model. Dis Colon Rectum. 2010;53(7):1069–75.PubMedCrossRefGoogle Scholar
  27. 27.
    Levison ME. Effect of colon flora and short-chain fatty acids on growth in vitro of Pseudomonas aeruginsoa and Enterobacteriaceae. Infect Immun. 1973;8(1):30–5.PubMedPubMedCentralGoogle Scholar
  28. 28.
    Sugarbaker PH. Progressive release of the left colon for a tension-free colorectal or coloanal anastomosis. Cancer Treat Res.1996;82:255–61.PubMedCrossRefGoogle Scholar
  29. 29.
    Uraiqat AA, Byrne CMD, Phillips RKS. Gaining length in ileal-anal pouch reconstruction: a review. Colorectal Dis. 2007;9(7):657–61.PubMedCrossRefGoogle Scholar
  30. 30.
    Wu X-R, Kirat HT, Xhaja X, Hammel JP, Kiran RP, Church JM. The impact of mesenteric tension on pouch outcome and quality of life in patients undergoing restorative proctocolectomy. Colorectal Dis. 2014;16(12):986–94.PubMedCrossRefGoogle Scholar
  31. 31.
    Chekan E, Whelan R. Surgical stapling device-tissue interactions: what surgeons need to know to improve patient outcomes. Med Devices (Auckl). 2014;7:305-18Google Scholar
  32. 32.
    Zilling T, Walther BS. Are intersecting staple lines a hazard in intestinal anastomosis? Dis Colon Rectum. 1992;35(9):892–6.PubMedCrossRefGoogle Scholar
  33. 33.
    Kawada K, Hasegawa S, Hida K, Hirai K, Okoshi K, Nomura A, Kawamura J, Nagayama S, Sakai Y. Risk factors for anastomotic leakage after laparoscopic low anterior resection with DST anastomosis. Surg Endosc. 2014;28(10):2988–95.PubMedPubMedCentralCrossRefGoogle Scholar
  34. 34.
    Ito M, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y, Saito N. Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. Int J Colorectal Dis. 2008;23(7):703–7.PubMedCrossRefGoogle Scholar
  35. 35.
    Park JS, Choi G-S, Kim SH, Kim HR, Kim NK, Lee KY, Kang S-B, Kim JY, Lee KY, Kim BC, Bae BN, Son GM, Lee SI, Kang H. Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group. Ann Surg. 2013;257(4):665–71.PubMedCrossRefGoogle Scholar
  36. 36.
    Qu H, Liu Y, Bi D-S. Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis. Surg Endosc. 2015;29(12):3608-17.PubMedCrossRefGoogle Scholar
  37. 37.
    Deng X-F, Liu Q-X, Zhou D, Min J-X, Dai J-G. Hand-sewn vs linearly stapled esophagogastric anastomosis for esophageal cancer: a meta-analysis. World J Gastroenterol. 2015;21(15):4757–64.PubMedPubMedCentralGoogle Scholar
  38. 38.
    Naumann DN, Bhangu A, Kelly M, Bowley DM. Stapled versus handsewn intestinal anastomosis in emergency laparotomy: a systemic review and meta-analysis. Surgery. 2015;157(4):609–18.PubMedCrossRefGoogle Scholar
  39. 39.
    Neutzling CB, Lustosa SAS, Proenca IM, da Silva EMK, Matos D. Stapled versus handsewn methods for colorectal anastomosis surgery. Cochrane Database Syst Rev. 2012;2:CD003144.Google Scholar
  40. 40.
    Honda M, Kuriyama A, Noma H, Nunobe S, Furukawa TA. Hand-sewn versus mechanical esophagogastric anastomosis after esophagectomy: a systematic review and meta-analysis. Ann Surg. 2013;257(2):238–48.PubMedCrossRefGoogle Scholar
  41. 41.
    Konishi T, Watanabe T, Kishimoto J, Nagawa H. Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance. J Am Coll Surg. 2006;202(3):439–44.PubMedCrossRefGoogle Scholar
  42. 42.
    Boyle NH, Manifold D, Jordan MH, Mason RC. Intraoperative assessment of colonic perfusion using scanning laser Doppler flowmetry during colonic resection. J Am Coll Surg. 2000;191(5):504–10.PubMedCrossRefGoogle Scholar
  43. 43.
    Kashiwagi H. The lower limit of tissue blood flow for safe colonic anastomosis: an experimental study using laser Doppler velocimetry. Surg Today. 1993;23(5):430–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Vignali A, Gianotti L, Braga M, Radaelli G, Malvezzi L, Di Carlo V. Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak. Dis Colon Rectum. 2000;43(1):76–82.PubMedCrossRefGoogle Scholar
  45. 45.
    Sheridan WG, Lowndes RH, Young HL. Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis Colon Rectum. 1987;30(11):867–71.PubMedCrossRefGoogle Scholar
  46. 46.
    Buunen M, Lange MM, Ditzel M, Kleinrensink G-J, van de Velde CJH, Lange JF. Level of arterial ligation in total mesorectal excision (TME): an anatomical study. Int J Colorectal Dis. 2009;24(11):1317–20.PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Trencheva K, Morrissey KP, Wells M, Mancuso CA, Lee SW, Sonoda T, Michelassi F, Charlson ME, Milsom JW. Identifying important predictors for anastomotic leak after colon and rectal resection: prospective study on 616 patients. Ann Surg. 2013;257(1):108–13.PubMedCrossRefGoogle Scholar
  48. 48.
    Meyers MA. Griffiths’ point: critical anastomosis at the splenic flexure. Significance in ischemia of the colon. AJR Am J Roentgenol. 1976;126(1):77–94.PubMedCrossRefGoogle Scholar
  49. 49.
    Myers C, Mutafyan G, Petersen R, Pryor A, Reynolds J, Demaria E. Real-time probe measurement of tissue oxygenation during gastrointestinal stapling: mucosal ischemia occurs and is not influenced by staple height. Surg Endosc. 2009;23(10):2345–50.PubMedCrossRefGoogle Scholar
  50. 50.
    Ishii M, Tanaka E, Imaizumi T, et al. Local VEGF administration enhances healing of colonic anastomoses in a rabbit model. Eur Surg Res 2009;42:249;PubMedCrossRefGoogle Scholar
  51. 51.
    Enestvedt CK, Hosack L, Hoppo T, et al. Recombinant vascular endothelial growth factor165 gene therapy improves anastomotic healing in an animal model of ischemic esophagogastrostomy. Dis Esophagus 2012;25: 456Google Scholar
  52. 52.
    Midura EF, Hanseman D, Davis BR, Atkinson SJ, Abbott DE, Shah SA, Paquette IM. Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum. 2015;58(3):333–8.PubMedCrossRefGoogle Scholar
  53. 53.
    Lipska MA, Bissett IP, Parry BR, Merrie AEH. Anastomotic leakage after lower gastrointestinal anastomosis: men are at a higher risk. ANZ J Surg. 2006;76(7):579–85.PubMedCrossRefGoogle Scholar
  54. 54.
    Kirchhoff P, Clavien P-A, Hahnloser D. Complications in colorectal surgery: risk factors and preventive strategies. Patient Saf Surg. 2010;4(1):5.PubMedPubMedCentralCrossRefGoogle Scholar
  55. 55.
    Keylock KT, Vieira VJ, Wallig MA, DiPietro LA, Schrementi M, Woods JA. Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol Regul Integr Comp Physiol. 2008;294(1):R179–84.PubMedCrossRefGoogle Scholar
  56. 56.
    Posma LAE, Bleichrodt RP, van Goor H, Hendriks T. Transient profound mesenteric ischemia strongly affects the strength of intestinal anastomoses in the rat. Dis Colon Rectum. 2007;50(7):1070–9.PubMedCrossRefGoogle Scholar
  57. 57.
    Kologlu M, Yorganci K, Renda N, Sayek I. Effect of local and remote ischemia-reperfusion injury on healing of colonic anastomoses. Surgery. 2000;128(1):99–104.PubMedCrossRefGoogle Scholar
  58. 58.
    Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219–29.PubMedPubMedCentralCrossRefGoogle Scholar
  59. 59.
    Ormiston MC. A study of rat intestinal wound healing in the presence of radiation injury. Br J Surg. 1985;72(1):56–8.PubMedCrossRefGoogle Scholar
  60. 60.
    Kingham TP, Pachter HL. Colonic anastomotic leak: risk factors, diagnosis, and treatment. J Am Coll Surg. 2009;208(2):269–78.PubMedCrossRefGoogle Scholar
  61. 61.
    Park MG, Hur H, Min BS, Lee KY, Kim NK. Colonic ischemia following surgery for sigmoid colon and rectal cancer: a study of 10 cases and a review of the literature. Int J Colorectal Dis. 2012;27(5):671–5.PubMedCrossRefGoogle Scholar
  62. 62.
    Pommergaard HC, Gessler B, Burcharth J, Angenete E, Haglind E, Rosenberg J. Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 2014;16(9):662–71.PubMedCrossRefGoogle Scholar
  63. 63.
    Pettersson D, Cedermark B, Holm T, Radu C, Påhlman L, Glimelius B, Martling A. Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. Br J Surg. 2010;97(4):580–7.PubMedCrossRefGoogle Scholar
  64. 64.
    Biere SSAY, Maas KW, Cuesta MA, van der Peet DL. Cervical or Thoracic Anastomosis after Esophagectomy for Cancer: A Systematic Review and Meta-Analysis. Dig Surg. 2011;28(1):29–35.PubMedCrossRefGoogle Scholar
  65. 65.
    Pettigrew RA, Hill GL. Indicators of surgical risk and clinical judgement. Br J Surg. 1986;73(1):47–51.PubMedCrossRefGoogle Scholar
  66. 66.
    Pettigrew RA, Burns HJ, Carter DC. Evaluating surgical risk: the importance of technical factors in determining outcome. Br J Surg. 1987;74(9):791–4.PubMedCrossRefGoogle Scholar
  67. 67.
    Karliczek A, Harlaar NJ, Zeebregts CJ, Wiggers T, Baas PC, van Dam GM. Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery. Int J Colorectal Dis. 2009;24(5):569–76.PubMedCrossRefGoogle Scholar
  68. 68.
    Markus PM, Martell J, Leister I, Horstmann O, Brinker J, Becker H. Predicting postoperative morbidity by clinical assessment. Br J Surg. 2005;92(1):101–6.PubMedCrossRefGoogle Scholar
  69. 69.
    Dulk den M, Noter SL, Hendriks ER, Brouwers MAM, van der Vlies CH, Oostenbroek RJ, Menon AG, Steup WH, van de Velde CJH. Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. Eur J Surg Oncol. 2009;35(4):420–6.Google Scholar
  70. 70.
    Baker RS, Foote J, Kemmeter P, Brady R, Vroegop T, Serveld M. The science of stapling and leaks. Obes Surg. 2004;14(10):1290–8.PubMedCrossRefGoogle Scholar
  71. 71.
    Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg. 2007;245(2):254–8.PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Morks AN, Ploeg RJ, Sijbrand Hofker H, Wiggers T, Havenga K. Late anastomotic leakage in colorectal surgery: a significant problem. Colorectal Dis. 2013;15(5):e271–5.PubMedCrossRefGoogle Scholar
  73. 73.
    Matthiessen P, Hallb k O, Ruteg rd JR, Simert GR, Sj dahl R. Defunctioning Stoma Reduces Symptomatic Anastomotic Leakage After Low Anterior Resection of the Rectum for Cancer. Ann Surg. 2007;246(2):207–14.Google Scholar
  74. 74.
    Singh PP, Zeng ISL, Srinivasa S, Lemanu DP, Connolly AB, Hill AG. Systematic review and meta-analysis of use of serum C-reactive protein levels to predict anastomotic leak after colorectal surgery. Br J Surg. 2013 Dec 5;101(4):339–46.Google Scholar
  75. 75.
    Warschkow R, Beutner U, Steffen T, Müller SA, Schmied BM, Güller U, Tarantino I. Safe and Early Discharge After Colorectal Surgery Due to C-Reactive Protein. Ann Surg. 2012;256(2):245–50.PubMedCrossRefGoogle Scholar
  76. 76.
    Giaccaglia V, Salvi PF, Antonelli MS, Nigri G, Pirozzi F, Casagranda B, Giacca M, Corcione F, de Manzini N, Balducci G, Ramacciato G. Procalcitonin Reveals Early Dehiscence in Colorectal Surgery. Ann Surg. 2016;263(5):967-72PubMedCrossRefGoogle Scholar
  77. 77.
    Romain B, Chemaly R, Meyer N, Chilintseva N, Triki E, Brigand C, Rohr S. Diagnostic markers of postoperative morbidity after laparoscopic Roux-en-Y gastric bypass for obesity. Langenbecks Arch Surg. 2014;399(4):503–8.PubMedCrossRefGoogle Scholar
  78. 78.
    Noble F, Curtis N, Harris S, Kelly JJ, Bailey IS, Byrne JP, Underwood TJ. Risk Assessment Using a Novel Score to Predict Anastomotic Leak and Major Complications after Oesophageal Resection. J Gastrointest Surg. 2012;16(6):1083–95.PubMedCrossRefGoogle Scholar
  79. 79.
    Herwig R, Glodny B, Kühle C, Schlüter B, Brinkmann OA, Strasser H, Senninger N, Winde G. Early identification of peritonitis by peritoneal cytokine measurement. Dis Colon Rectum. 2002;45(4):514–21.PubMedCrossRefGoogle Scholar
  80. 80.
    Fouda E, Nakeeb El A, Magdy A, Hammad EA, Othman G, Farid M. Early detection of anastomotic leakage after elective low anterior resection. J Gastrointest Surg. 2011;15(1):137–44.Google Scholar
  81. 81.
    Yamamoto T, Umegae S, Matsumoto K, Saniabadi AR. Peritoneal cytokines as early markers of peritonitis following surgery for colorectal carcinoma: a prospective study. Cytokine. 2011;53(2):239–42.PubMedCrossRefGoogle Scholar
  82. 82.
    Adams K, Papagrigoriadis S. Little consensus in either definition or diagnosis of a lower gastro-intestinal anastomotic leak amongst colorectal surgeons. Int J Colorectal Dis. 2013;28(7):967-71PubMedCrossRefGoogle Scholar
  83. 83.
    Alves A, Panis Y, Pocard M, Regimbeau JM, Valleur P. Management of anastomotic leakage after nondiverted large bowel resection. J Am Coll Surg. 1999;189(6):554–9.PubMedCrossRefGoogle Scholar
  84. 84.
    Strauss C, Mal F, Perniceni T, Bouzar N, Lenoir S, Gayet B, Palau R. Computed tomography versus water-soluble contrast swallow in the detection of intrathoracic anastomotic leak complicating esophagogastrectomy (Ivor Lewis): a prospective study in 97 patients. Ann Surg. 2010;251(4):647–51.PubMedCrossRefGoogle Scholar
  85. 85.
    Daams F. Prediction and diagnosis of colorectal anastomotic leakage: A systematic review of literature. World J Gastrointest Surg. 2014;6(2):14-26.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    86 Rickles AS, Iannuzzi JC, Kelly KN, Cooney RN, Brown DA, Davidson M, Hellenthal N, Max C, Johnson J, DeTraglia J, McGurrin M, Kimball R, DiBenedetto A, Galyon D, Esposito SL, Noyes K, Monson JRT, Fleming FJ, UNYSQI Collaborative. Anastomotic leak or organ space surgical site infection: What are we missing in our quality improvement programs? Surgery. 2013;154(4):680–7–discussion 687–9.Google Scholar
  87. 87.
    Beard JD, Nicholson ML, Sayers RD, Lloyd D, Everson NW. Intraoperative air testing of colorectal anastomoses: a prospective, randomized trial. Br J Surg. 1990;77(10):1095–7.PubMedCrossRefGoogle Scholar
  88. 88.
    Nachiappan S, Askari A, Currie A, Kennedy RH, Faiz O. Intraoperative assessment of colorectal anastomotic integrity: a systematic review. Surg Endosc. 2014;28(9):2513–30.PubMedCrossRefGoogle Scholar
  89. 89.
    Shin RB. Intraoperative endoscopic test resulting in no postoperative leaks from the gastric pouch and gastrojejunal anastomosis in 366 laparoscopic Roux-en-Y gastric bypasses. Obes Surg. 2004;14(8):1067–9.PubMedCrossRefGoogle Scholar
  90. 90.
    Kligman MD. Intraoperative endoscopic pneumatic testing for gastrojejunal anastomotic integrity during laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2007;21(8):1403–5.PubMedCrossRefGoogle Scholar
  91. 91.
    Kanaji S, Ohyama M, Yasuda T, Sendo H, Suzuki S, Kawasaki K, Tanaka K, Fujino Y, Tominaga M, Kakeji Y. Can the intraoperative leak test prevent postoperative leakage of esophagojejunal anastomosis after total gastrectomy? Surg Today. 2015;46(7):815–20.PubMedCrossRefGoogle Scholar
  92. 92.
    Sethi M, Zagzag J, Patel K, Magrath M, Somoza E, Parikh MS, Saunders JK, Ude-Welcome A, Schwack BF, Kurian MS, Fielding GA, Ren-Fielding CJ. Intraoperative leak testing has no correlation with leak after laparoscopic sleeve gastrectomy. Surg Endosc. 2016;30(3):883–91.PubMedCrossRefGoogle Scholar
  93. 93.
    Bingham J, Lallemand M, Barron M. Routine intraoperative leak testing for sleeve gastrectomy: is the leak test full of hot air? Am J Surg 2016;211(5):943-7.PubMedCrossRefGoogle Scholar
  94. 94.
    Elagili F, Stocchi L, Ozuner G, Dietz DW, Kiran RP. Outcomes of Percutaneous Drainage Without Surgery for Patients With Diverticular Abscess. Dis Colon Rectum. 2014;57(3):331–6.Google Scholar
  95. 95.
    Siewert B, Tye G, Kruskal J, Sosna J, Opelka F, Raptopoulos V, Goldberg SN. Impact of CT-guided drainage in the treatment of diverticular abscesses: size matters. AJR Am J Roentgenol. 2006;186(3):680–6.PubMedCrossRefGoogle Scholar
  96. 96.
    Johnson WC, Gerzof SG, Robbins AH, Nabseth DC. Treatment of abdominal abscesses: comparative evaluation of operative drainage versus percutaneous catheter drainage guided by computed tomography or ultrasound. Ann Surg. 1981;194(4):510–20.PubMedPubMedCentralCrossRefGoogle Scholar
  97. 97.
    Olak J, Christou NV, Stein LA, Casola G, Meakins JL. Operative vs percutaneous drainage of intra-abdominal abscesses. Comparison of morbidity and mortality. Arch Surg. 1986;121(2):141–6.PubMedCrossRefGoogle Scholar
  98. 98.
    Khurrum Baig M, Hua Zhao R, Batista O, Uriburu JP, Singh JJ, Weiss EG, Nogueras JJ, Wexner SD. Percutaneous postoperative intra-abdominal abscess drainage after elective colorectal surgery. Tech Coloproctol. 2002;6(3):159–64.PubMedCrossRefGoogle Scholar
  99. 99.
    Abbas MA. Endoscopic management of acute colorectal anastomotic complications with temporary stent. JSLS. 2009;13(3):420–4.PubMedPubMedCentralGoogle Scholar
  100. 100.
    Lamazza A, Fiori E, De Masi E, Scoglio D, Sterpetti A, Lezoche E. Self-expanding metal stents for treatment of anastomotic complications after colorectal resection. Endoscopy. 2013;45(06):493–5.PubMedCrossRefGoogle Scholar
  101. 101.
    Lamazza A, Fiori E, Schillaci A, Sterpetti AV, Lezoche E. Treatment of anastomotic stenosis and leakage after colorectal resection for cancer with self-expandable metal stents. Am J Surg. 2014;208(3):465–9.PubMedCrossRefGoogle Scholar
  102. 102.
    Cooper CJ, Morales A, Othman MO. Outcomes of the use of fully covered esophageal self-expandable stent in the management of colorectal anastomotic strictures and leaks. Diagn Ther Endosc. 2014;2014(3):187541–6.PubMedPubMedCentralGoogle Scholar
  103. 103.
    van den Berg MW, Kerbert AC, van Soest EJ, Schwartz MP, Bakker CM, Gilissen LPL, van Hooft JE. Safety and efficacy of a fully covered large-diameter self-expanding metal stent for the treatment of upper gastrointestinal perforations, anastomotic leaks, and fistula. Dis Esophagus. 2015. doi:  10.1111/dote.12363. [Epub ahead of print]PubMedGoogle Scholar
  104. 104.
    Glitsch A, Bernstorff von W, Seltrecht U, Partecke I, Paul H, Heidecke CD. Endoscopic transanal vacuum-assisted rectal drainage (ETVARD): an optimized therapy for major leaks from extraperitoneal rectal anastomoses. Endoscopy. 2008;40(3):192–9.Google Scholar
  105. 105.
    Bernstorff von W, Glitsch A, Schreiber A, Partecke LI, Heidecke CD. ETVARD (endoscopic transanal vacuum-assisted rectal drainage) leads to complete but delayed closure of extraperitoneal rectal anastomotic leakage cavities following neoadjuvant radiochemotherapy. Int J Colorectal Dis. 2009;24(7):819–25.Google Scholar
  106. 106.
    Arezzo A, Verra M, Passera R, Bullano A, Rapetti L, Morino M. Long-term efficacy of endoscopic vacuum therapy for the treatment of colorectal anastomotic leaks. Dig Liver Dis. 2015;47(4):342–5.PubMedCrossRefGoogle Scholar
  107. 107.
    Smallwood NR, Fleshman JW, Leeds SG, Burdick JS. The use of endoluminal vacuum (E-Vac) therapy in the management of upper gastrointestinal leaks and perforations. Surg Endosc. 2016;30(6):2473-80PubMedCrossRefGoogle Scholar
  108. 108.
    Kuehn F, Schiffmann L, Janisch F, Schwandner F, Alsfasser G, Gock M, Klar E. Surgical Endoscopic Vacuum Therapy for Defects of the Upper Gastrointestinal Tract. J Gastrointest Surg. J Gastrointest Surg. 2016;20(2):237-43.PubMedCrossRefGoogle Scholar
  109. 109.
    Mennigen R. Novel treatment options for perforations of the upper gastrointestinal tract: Endoscopic vacuum therapy and over-the-scope clips. WJG. 2014;20(24):7767–11.PubMedPubMedCentralCrossRefGoogle Scholar
  110. 110.
    Sulz MC, Bertolini R, Frei R, Semadeni G-M, Borovicka J, Meyenberger C. Multipurpose use of the over-the-scope-clip system (“Bear claw”) in the gastrointestinal tract: Swiss experience in a tertiary center. World J Gastroenterol. 2014;20(43):16287–92.PubMedPubMedCentralCrossRefGoogle Scholar
  111. 111.
    Weiland T, Fehlker M, Gottwald T, Schurr MO. Performance of the OTSC System in the endoscopic closure of iatrogenic gastrointestinal perforations: a systematic review. Surg Endosc. 2013;27(7):2258–74.PubMedCrossRefGoogle Scholar
  112. 112.
    Mizrahi I, Eltawil R, Haim N, et al. The Clinical Utility of Over the Scope Clip for the Treatment of Gastrointestinal Defects. J Gastrointest Surg. 2016 (in press).Google Scholar
  113. 113.
    Longo WE, Milsom JW, Lavery IC, Church JC, Oakley JR, Fazio VW. Pelvic abscess after colon and rectal surgery-what is optimal management? Dis Colon Rectum. 1993;36(10):936–41.PubMedCrossRefGoogle Scholar
  114. 114.
    Blumetti J, Chaudhry V, Cintron JR, Park JJ, Marecik S, Harrison JL, Prasad LM, Abcarian H. Management of Anastomotic Leak: Lessons Learned from a Large Colon and Rectal Surgery Training Program. World J Surg. 2013;38(4):985–91.CrossRefGoogle Scholar
  115. 115.
    Krarup P, Jorgensen LN, Harling H, Danish Colorectal Cancer Group. Management of anastomotic leakage in a nationwide cohort of colonic cancer patients. J Am Coll Surg. 2014;218(5):940–9.PubMedCrossRefGoogle Scholar
  116. 116.
    Wind J, Koopman AG, van Berge Henegouwen MI, Slors JFM, Gouma DJ, Bemelman WA. Laparoscopic reintervention for anastomotic leakage after primary laparoscopic colorectal surgery. Br J Surg. 2007;94(12):1562–6.PubMedCrossRefGoogle Scholar
  117. 117.
    Lee CM, Huh JW, Yun SH, Kim HC, Lee WY, Park YA, Cho YB, Chun H-K. Laparoscopic versus open reintervention for anastomotic leakage following minimally invasive colorectal surgery. Surg Endosc. 2015;29(4):931–6.PubMedCrossRefGoogle Scholar
  118. 118.
    Vennix S, Abegg R, Bakker OJ, van den Boezem PB, Brokelman WJA, Sietses C, Bosscha K, Lips DJ, Prins HA. Surgical re-interventions following colorectal surgery: open versus laparoscopic management of anastomotic leakage. J Laparoendosc Adv Surg Tech A. 2013;23(9):739–44.PubMedCrossRefGoogle Scholar
  119. 119.
    Kabul Gürbulak E, Akgün İE, Öz A, Ömeroğlu S, Battal M, Celayir F, Mihmanlı M. Minimal invasive management of anastomosis leakage after colon resection. Case Rep Med. 2015;2015(10):374072–4.PubMedPubMedCentralGoogle Scholar
  120. 120.
    Brunner W, Rossetti A, Vines LC, Kalak N, Bischofberger SA. Anastomotic leakage after laparoscopic single-port sigmoid resection: combined transanal and transabdominal minimal invasive management. Surg Endosc. 2015;29(12):3803-5PubMedCrossRefGoogle Scholar
  121. 121.
    Asgeirsson T, Jrebi N, Jebri N, Feo L, Kerwel T, Luchtefeld M, Senagore AJ. Incremental cost of complications in colectomy: a warranty guided approach to surgical quality improvement. Am J Surg. 2014;207(3):422–6–discussion 425–6.Google Scholar
  122. 122.
    Nesbakken A, Nygaard K, Lunde OC. Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg. 2001;88(3):400–4.PubMedCrossRefGoogle Scholar
  123. 123.
    Hallböök O, Sjödahl R. Anastomotic leakage and functional outcome after anterior resection of the rectum. Br J Surg. 1996;83(1):60–2.PubMedCrossRefGoogle Scholar
  124. 124.
    Ashburn JH, Stocchi L, Kiran RP, Dietz DW, Remzi FH. Consequences of Anastomotic Leak After Restorative Proctectomy for Cancer. Dis Colon Rectum. 2013;56(3):275–80.PubMedCrossRefGoogle Scholar
  125. 125.
    Marinatou A, Theodoropoulos GE, Karanika S, Karantanos T, Siakavellas S, Spyropoulos BG, Toutouzas K, Zografos G. Do Anastomotic Leaks Impair Postoperative Health-related Quality of Life After Rectal Cancer Surgery? A Case-matched Study. Dis Colon Rectum. 2014;57(2):158–66.PubMedCrossRefGoogle Scholar
  126. 126.
    Killeen S, Souroullas P, Ho Tin H, Hunter IA, O’Grady H, Gunn J, Hartley JE. Outcomes of Asymptomatic Anastomotic Leaks Found on Routine Postoperative Water-soluble Enema following Anterior Resection for Cancer. World J Surg. 2013;37(11):2700–4.PubMedCrossRefGoogle Scholar
  127. 127.
    Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36(1):77–97.PubMedCrossRefGoogle Scholar
  128. 128.
    Rockwood TH, Church JM, Fleshman JW, Kane RL, Mavrantonis C, Thorson AG, Wexner SD, Bliss D, Lowry AC. Fecal Incontinence Quality of Life Scale: quality of life instrument for patients with fecal incontinence. Dis Colon Rectum. 2000;43(1):9–16–discussion16–7.Google Scholar
  129. 129.
    Killeen S, Devaney A, Mannion M, Martin ST, Winter DC. Omental pedicle flaps following proctectomy: a systematic review. Colorectal Dis. 2013;15(11):e634–45.PubMedCrossRefGoogle Scholar
  130. 130.
    Espín E, Ciga MA, Pera M, Ortiz H, Spanish Rectal Cancer Project. Oncological outcome following anastomotic leak in rectal surgery. Br J Surg. 2015 Mar;102(4):416–22.Google Scholar
  131. 131.
    Smith JD, Paty PB, Guillem JG, Temple LK, Weiser MR, Nash GM. Anastomotic Leak Is Not Associated With Oncologic Outcome in Patients Undergoing Low Anterior Resection for Rectal Cancer. Ann Surg. 2012;256(6):1034–8.PubMedCrossRefGoogle Scholar
  132. 132.
    Smith JD, Butte JM, Weiser MR, D’Angelica MI, Paty PB, Temple LK, Guillem JG, Jarnagin WR, Nash GM. Anastomotic leak following low anterior resection in stage IV rectal cancer is associated with poor survival. Ann Surg Oncol. 2013;20(8):2641–6.PubMedCrossRefGoogle Scholar
  133. 133.
    Nachiappan S, Askari A, Malietzis G, Giacometti M, White I, Jenkins JT, Kennedy RH, Faiz O. The impact of anastomotic leak and its treatment on cancer recurrence and survival following elective colorectal cancer resection. World J Surg. 2015;39(4):1052–8.PubMedCrossRefGoogle Scholar
  134. 134.
    Ptok H, Marusch F, Meyer F, Schubert D, Gastinger I, Lippert H, Study Group Colon/Rectum Carcinoma (Primary Tumour). Impact of anastomotic leakage on oncological outcome after rectal cancer resection. Br J Surg. 2007;94(12):1548–54.PubMedCrossRefGoogle Scholar
  135. 135.
    McArdle CS, McMillan DC, Hole DJ. Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg. 2005;92(9):1150–4.PubMedCrossRefGoogle Scholar
  136. 136.
    Law WL, Choi HK, Lee YM, Ho JWC, Seto CL. Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg. 2007;11(1):8–15.PubMedCrossRefGoogle Scholar
  137. 137.
    Lin J-K, Yueh T-C, Chang S-C, Lin C-C, Lan Y-T, Wang H-S, Yang S-H, Jiang J-K, Chen W-S, Lin T-C. The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer. J Gastrointest Surg. 2011;15(12):2251–61.PubMedCrossRefGoogle Scholar
  138. 138.
    Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg. 2011;253(5):890–9.PubMedCrossRefGoogle Scholar
  139. 139.
    Jenner DC, de Boer WB, Clarke G, Levitt MD. Rectal washout eliminates exfoliated malignant cells. Dis Colon Rectum. 1998;41(11):1432–4.PubMedCrossRefGoogle Scholar
  140. 140.
    Gertsch P, Baer HU, Kraft R, Maddern GJ, Altermatt HJ. Malignant cells are collected on circular staplers. Dis Colon Rectum. 1992;35(3):238–41.PubMedCrossRefGoogle Scholar
  141. 141.
    Sayfan J, Averbuch F, Koltun L, Benyamin N. Effect of rectal stump washout on the presence of free malignant cells in the rectum during anterior resection for rectal cancer. Dis Colon Rectum. 2000 Dec;43(12):1710–2.Google Scholar
  142. 142.
    Fermor B, Umpleby HC, Lever JV, Symes MO, Williamson RC. Proliferative and metastatic potential of exfoliated colorectal cancer cells. J Natl Cancer Inst. 1986;76(2):347–9.PubMedGoogle Scholar
  143. 143.
    LeVeen HH, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M. Effects of prophylactic antibiotics on colonic healing. Am J Surg. 1976;131(1):47–53.PubMedCrossRefGoogle Scholar
  144. 144.
    Kiran RP, Murray ACA, Chiuzan C, Estrada D, Forde K. Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery. Ann Surg. 2015;262(3):416–25–discussion423–5.Google Scholar
  145. 145.
    Scarborough JE, Mantyh CR, Sun Z, Migaly J. Combined Mechanical and Oral Antibiotic Bowel Preparation Reduces Incisional Surgical Site Infection and Anastomotic Leak Rates After Elective Colorectal Resection. Ann Surg. 2015;262(2):331–7.PubMedCrossRefGoogle Scholar
  146. 146.
    Roos D, Dijksman LM, Tijssen JG, Gouma DJ, Gerhards MF, Oudemans-van Straaten HM. Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery. Br J Surg. 2013;100(12):1579–88.PubMedCrossRefGoogle Scholar
  147. 147.
    Enker WE, Merchant N, Cohen AM, Lanouette NM, Swallow C, Guillem J, Paty P, Minsky B, Weyrauch K, Quan SH. Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service. Ann Surg. 1999;230(4):544–52–discussion552–4.Google Scholar
  148. 148.
    Leester B, Asztalos I, Polnyib C. Septic complications after low anterior rectal resection-is diverting stoma still justified? Acta Chir Iugosl. 2002;49(2):67–71.PubMedCrossRefGoogle Scholar
  149. 149.
    Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg. 1998;85(3):355–8.PubMedCrossRefGoogle Scholar
  150. 150.
    Matthiessen P, Hallböök O, Andersson M, Rutegård J, Sjödahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis. 2004;6(6):462–9.PubMedCrossRefGoogle Scholar
  151. 151.
    Chude GG, Rayate NV, Patris V, Koshariya M, Jagad R, Kawamoto J, Lygidakis NJ. Defunctioning loop ileostomy with low anterior resection for distal rectal cancer: should we make an ileostomy as a routine procedure? A prospective randomized study. Hepatogastroenterology. 2008;55(86-87):1562–7.PubMedGoogle Scholar
  152. 152.
    Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic Review and Meta-Analysis of the Role of Defunctioning Stoma in Low Rectal Cancer Surgery. Ann Surg. 2008;248(1):52–60.PubMedCrossRefGoogle Scholar
  153. 153.
    Montedori A, Cirocchi R, Farinella E, Sciannameo F, Abraha I. Covering ileo- or colostomy in anterior resection for rectal carcinoma. Cochrane Database Syst Rev. 2010;(5):CD006878.Google Scholar
  154. 154.
    Herrle F, Sandra-Petrescu F, Weiss C, Post S, Runkel N, Kienle P. Quality of Life and Timing of Stoma Closure in Patients With Rectal Cancer Undergoing Low Anterior Resection With Diverting Stoma: A Multicenter Longitudinal Observational Study. Dis Colon Rectum. 2016;59(4):281–90.PubMedCrossRefGoogle Scholar
  155. 155.
    Ihnát P, Guňková P, Peteja M, Vávra P, Pelikán A, Zonča P. Diverting ileostomy in laparoscopic rectal cancer surgery: high price of protection. Surg Endosc. 2016 Feb 22. [E-pub].Google Scholar
  156. 156.
    Rutegård M, Boström P, Haapamäki M, Matthiessen P, Rutegård J. Current use of diverting stoma in anterior resection for cancer: population-based cohort study of total and partial mesorectal excision. Int J Colorectal Dis. 2016;31(3):579–85.PubMedCrossRefGoogle Scholar
  157. 157.
    D’Hoore A, Albert MR, Cohen SM, Herbst F, Matter I, Van Der Speeten K, Dominguez J, Rutten H, Muldoon JP, Bardakcioglu O, Senagore AJ, Ruppert R, Mills S, Stamos MJ, Påhlman L, Choman E, Wexner SD, COMPRES collaborative study group. COMPRES: a prospective postmarketing evaluation of the compression anastomosis ring CAR 27(™) /ColonRing(™). Colorectal Dis. 2015;17(6):522–9.PubMedCrossRefGoogle Scholar
  158. 158.
    Berho M, Wexner SD, Botero-Anug A-M, Pelled D, Fleshman JW. Histopathologic advantages of compression ring anastomosis healing as compared with stapled anastomosis in a porcine model: a blinded comparative study. Dis Colon Rectum. 2014;57(4):506–13.PubMedCrossRefGoogle Scholar
  159. 159.
    Juo Y-Y, Hyder O, Haider AH, Camp M, Lidor A, Ahuja N. Is minimally invasive colon resection better than traditional approaches?: First comprehensive national examination with propensity score matching. JAMA Surg. 2014;149(2):177–84.PubMedPubMedCentralCrossRefGoogle Scholar
  160. 160.
    Xu H, Li J, Sun Y, Li Z, Zhen Y, Wang B, Xu Z. Robotic versus laparoscopic right colectomy: a meta-analysis. World J Surg Oncol. 2014;12(1):274.PubMedPubMedCentralCrossRefGoogle Scholar
  161. 161.
    Petrucciani N, Sirimarco D, Nigri GR, Magistri P, La Torre M, Aurello P, D’Angelo F, Ramacciato G. Robotic right colectomy: A worthwhile procedure? Results of a meta-analysis of trials comparing robotic versus laparoscopic right colectomy. J Minim Access Surg. 2015;11(1):22–8.PubMedPubMedCentralCrossRefGoogle Scholar
  162. 162.
    Park JS, Choi GS, Park SY, Kim HJ, Ryuk JP. Randomized clinical trial of robot-assisted versus standard laparoscopic right colectomy. Br J Surg. 2012;99(9):1219–26.PubMedCrossRefGoogle Scholar
  163. 163.
    Collinson FJ, Jayne DG, Pigazzi A, Tsang C, Barrie JM, Edlin R, Garbett C, Guillou P, Holloway I, Howard H, Marshall H, McCabe C, Pavitt S, Quirke P, Rivers CS, Brown JMB. An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer. Int J Colorectal Dis. 2012;27(2):233–41.PubMedCrossRefGoogle Scholar
  164. 164.
    Economopoulos KP, Theocharidis V, McKenzie TJ, Sergentanis TN, Psaltopoulou T. Robotic vs. Laparoscopic Roux-En-Y Gastric Bypass: a Systematic Review and Meta-Analysis. Obes Surg. 2015;25(11):2180–9.PubMedCrossRefGoogle Scholar
  165. 165.
    Xiong J, Nunes QM, Tan C, Ke N, Chen Y, Hu W, Liu X, Mai G. Comparison of Short-Term Clinical Outcomes Between Robotic and Laparoscopic Gastrectomy for Gastric Cancer: A Meta-analysis of 2495 Patients. J Laparoendosc Adv Surg Tech A. 2013;23(12):965–76.PubMedCrossRefGoogle Scholar
  166. 166.
    Novell JR, Lewis AA. Peroperative observation of marginal artery bleeding: a predictor of anastomotic leakage. Br J Surg. 1990;77(2):137–8.PubMedCrossRefGoogle Scholar
  167. 167.
    Karakaş BR, Sırcan-Küçüksayan A, Elpek OE, Canpolat M. Investigating viability of intestine using spectroscopy: a pilot study. J Surg Res. 2014;191(1):91–8.PubMedCrossRefGoogle Scholar
  168. 168.
    Karliczek A, Benaron DA, Baas PC, Zeebregts CJ, Wiggers T, van Dam GM. Intraoperative assessment of microperfusion with visible light spectroscopy for prediction of anastomotic leakage in colorectal anastomoses. Colorectal Dis. 2010;12(10):1018–25.PubMedCrossRefGoogle Scholar
  169. 169.
    Ambrosetti P, Robert J, Mathey P, Rohner A. Left-sided colon and colorectal anastomoses: Doppler ultrasound as an aid to assess bowel vascularization. A prospective evaluation of 200 consecutive elective cases. Int J Colorectal Dis. 1994;9(4):211–4.PubMedCrossRefGoogle Scholar
  170. 170.
    Ueno M, Osugi H, Suehiro S, Nishimura Y, Takada N, Takemura M, Kinoshita H. Evaluation of blood flow by color Doppler sonography in free jejunal interposition grafts for cervical esophageal reconstruction. World J Surg. 2005;29(3):382–7.PubMedCrossRefGoogle Scholar
  171. 171.
    Luo S, Zhang E, Su Y, Cheng T, Shi C. A review of NIR dyes in cancer targeting and imaging. Biomaterials. 2011 Oct;32(29):7127–38.Google Scholar
  172. 172.
    Alander JT, Kaartinen I, Laakso A, Pätilä T, Spillmann T, Tuchin VV, Venermo M, Välisuo P. A review of indocyanine green fluorescent imaging in surgery. Int J Biomed Imaging. 2012;2012(1):940585–26.PubMedPubMedCentralGoogle Scholar
  173. 173.
    Speich R, Saesseli B, Hoffmann U, Neftel KA, Reichen J. Anaphylactoid reactions after indocyanine-green administration. Ann Intern Med. 1988;109(4):345–6.PubMedCrossRefGoogle Scholar
  174. 174.
    Aume M, Kotake H, Kosaka T, Hoshio A, Yamasaki J, Hasegawa J, Furuse T, Mashiba H. Two cases of coronary artery spasm induced by indocyanine green. Jpn Heart J. 1988;29(6):877–81.PubMedCrossRefGoogle Scholar
  175. 175.
    Zehetner J, DeMeester SR, Alicuben ET, Oh DS, Lipham JC, Hagen JA, DeMeester TR. Intraoperative Assessment of Perfusion of the Gastric Graft and Correlation With Anastomotic Leaks After Esophagectomy. Ann Surg. 2015;262(1):74–8.PubMedPubMedCentralCrossRefGoogle Scholar
  176. 176.
    Oezcelik A, Banki F, DeMeester SR, Leers JM, Ayazi S, Abate E, Hagen JA, Lipham JC, DeMeester TR. Delayed Esophagogastrostomy: A Safe Strategy for Management of Patients with Ischemic Gastric Conduit at Time of Esophagectomy. J Am Coll Surg. 2009;208(6):1030–4.PubMedCrossRefGoogle Scholar
  177. 177.
    Yukaya T, Saeki H, Kasagi Y, Nakashima Y, Ando K, Imamura Y, Ohgaki K, Oki E, Morita M, Maehara Y. Indocyanine Green Fluorescence Angiography for Quantitative Evaluation of Gastric Tube Perfusion in Patients Undergoing Esophagectomy. J Am Coll Surg. 2015;221(2):e37–e42.PubMedCrossRefGoogle Scholar
  178. 178.
    Rino Y, Yukawa N, Sato T, Yamamoto N, Tamagawa H, Hasegawa S, Oshima T, Yoshikawa T, Masuda M, Imada T. Visualization of blood supply route to the reconstructed stomach by indocyanine green fluorescence imaging during esophagectomy. BMC Med Imaging. 2014;14:18PubMedPubMedCentralCrossRefGoogle Scholar
  179. 179.
    Saif MW, Elfiky A, Salem RR. Gastrointestinal perforation due to bevacizumab in colorectal cancer. Ann Surg Oncol. 2007;14(6):1860–9.PubMedCrossRefGoogle Scholar
  180. 180.
    Yauw STK, Lomme RMLM, van der Vijver RJ, Hendriks T, van Laarhoven KJHM, van Goor H. Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat. Am J Surg. 2015;210(2):382–8.PubMedCrossRefGoogle Scholar
  181. 181.
    Burton TP, Mittal A, Soop M. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence in bowel surgery: systematic review and meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2013;56(1):126–34.PubMedCrossRefGoogle Scholar
  182. 182.
    Amin AI, Ramalingam T, Sexton R, Heald RJ, Leppington-Clarke A, Moran BJ. Comparison of transanal stent with defunctioning stoma in low anterior resection for rectal cancer. Br J Surg. 2003;90(5):581–2.PubMedCrossRefGoogle Scholar
  183. 183.
    Bulow S, Bulut O, Christensen IJ, Harling H, The Rectal Stent Study Group 1. Transanal stent in anterior resection does not prevent anastomotic leakage. Colorectal Dis. 2006;8(6):494–6.PubMedCrossRefGoogle Scholar
  184. 184.
    Ye F, Wang D, Xu X, Liu F, Lin J. Use of Intracolonic Bypass Secured by a Biodegradable Anastomotic Ring to Protect the Low Rectal Anastomosis. Dis Colon Rectum. 2008;51(1):109–15.PubMedCrossRefGoogle Scholar
  185. 185.
    Kolkert JL, Havenga K, Cate Hoedemaker ten HO, Zuidema J, Ploeg RJ. Protection of stapled colorectal anastomoses with a biodegradable device: the C-Seal feasibility study. Am J Surg. 2011;201(6):754–8.Google Scholar
  186. 186.
    Morks AN, Havenga K, Cate Hoedemaker Ten HO, Leijtens JWA, Ploeg RJ. Thirty-seven patients treated with the C-seal: protection of stapled colorectal anastomoses with a biodegradable sheath. Int J Colorectal Dis. 2013;28(10):1433–8.Google Scholar
  187. 187.
    Shikora SA, Kim JJ, Tarnoff ME. Reinforcing gastric staple-lines with bovine pericardial strips may decrease the likelihood of gastric leak after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2003;13(1):37–44.PubMedCrossRefGoogle Scholar
  188. 188.
    Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG, Adhesion Study Group Steering Committee. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum. 2003;46(10):1310–9.Google Scholar
  189. 189.
    Liu CD, Glantz GJ, Livingston EH. Fibrin glue as a sealant for high-risk anastomosis in surgery for morbid obesity. Obes Surg. 2003;13(1):45–8.PubMedCrossRefGoogle Scholar
  190. 190.
    Silecchia G, Boru CE, Mouiel J, Rossi M, Anselmino M, Morino M, Toppino M, Gaspari A, Gentileschi P, Tacchino R, Basso N. The use of fibrin sealant to prevent major complications following laparoscopic gastric bypass: results of a multicenter, randomized trial. Surg Endosc. 2008;22(11):2492–7.PubMedCrossRefGoogle Scholar
  191. 191.
    Fullum TM, Aluka KJ, Turner PL. Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2009;23(6):1403–8.PubMedCrossRefGoogle Scholar
  192. 192.
    Efthimiou E, Al-Sabah S, Sampalis JS, Christou NV. Fibrin sealant associated with increased body temperature and leukocytosis after laparoscopic gastric bypass. Surg Obes Relat Dis. 2010;6(1):46–9.PubMedCrossRefGoogle Scholar
  193. 193.
    Huh JW, Kim HR, Kim YJ. Anastomotic leakage after laparoscopic resection of rectal cancer: the impact of fibrin glue. Am J Surg. 2010;199(4):435–41.PubMedCrossRefGoogle Scholar
  194. 194.
    Afaneh C, Abelson J, Schattner M, Janjigian YY, Ilson D, Yoon SS, Strong VE. Esophageal Reinforcement with an Extracellular Scaffold During Total Gastrectomy for Gastric Cancer. Ann Surg Oncol. 2014;22(4):1252–7.PubMedCrossRefGoogle Scholar
  195. 195.
    Shimada Y, Okumura T, Nagata T, Sawada S, Matsui K, Hori R, Yoshioka I, Yoshida T, Osada R, Tsukada K. Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy. Esophagus. 2011;8(4):259–66.PubMedPubMedCentralCrossRefGoogle Scholar
  196. 196.
    Kumagai Y, Ishiguro T, Haga N, Kuwabara K, Kawano T, Ishida H. Hemodynamics of the Reconstructed Gastric Tube During Esophagectomy: Assessment of Outcomes with Indocyanine Green Fluorescence. World J Surg. 2013;38(1):138–43.CrossRefGoogle Scholar
  197. 197.
    Sarkaria IS, Bains MS, Finley DJ, Adusumilli PS, Huang J, Rusch VW, Jones DR, Rizk NP. Intraoperative near-infrared fluorescence imaging as an adjunct to robotic-assisted minimally invasive esophagectomy. Innovations (Phila). 2014;9(5):391–3.CrossRefGoogle Scholar
  198. 198.
    Campbell C, Reames MK, Robinson M, Symanowski J, Salo JC. Conduit Vascular Evaluation is Associated with Reduction in Anastomotic Leak After Esophagectomy. J Gastrointest Surg. 2015;19(5):806–12.PubMedCrossRefGoogle Scholar
  199. 199.
    Kamiya K, Unno N, Miyazaki S, Sano M, Kikuchi H, Hiramatsu Y, Ohta M, Yamatodani T, Mineta H, Konno H. Quantitative assessment of the free jejunal graft perfusion. J Surg Res. 2015;194(2):394–9.PubMedCrossRefGoogle Scholar
  200. 200.
    Kudszus S, Roesel C, Schachtrupp A, Höer JJ. Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg. 2010;395(8):1025–30.PubMedCrossRefGoogle Scholar
  201. 201.
    Jafari MD, Lee KH, Halabi WJ, Mills SD, Carmichael JC, Stamos MJ, Pigazzi A. The use of indocyanine green fluorescence to assess anastomotic perfusion during robotic assisted laparoscopic rectal surgery. Surg Endosc. 2013;27(8):3003–8.PubMedCrossRefGoogle Scholar
  202. 202.
    Hellan M, Spinoglio G, Pigazzi A, Lagares-Garcia JA. The influence of fluorescence imaging on the location of bowel transection during robotic left-sided colorectal surgery. Surg Endosc. 2014;28(5):1695–702.PubMedCrossRefGoogle Scholar
  203. 203.
    Boni L, David G, Dionigi G, Rausei S, Cassinotti E, Fingerhut A. Indocyanine green-enhanced fluorescence to assess bowel perfusion during laparoscopic colorectal resection. Surg Endosc. 2015 Oct 20. [Epub ahead of print]Google Scholar
  204. 204.
    Protyniak B, Dinallo AM, Boyan WP. Intraoperative Indocyanine Green Fluorescence Angiography—An Objective Evaluation of Anastomotic Perfusion in Colorectal Surgery. Am Surg. 2015;81(6):580–4.PubMedGoogle Scholar
  205. 205.
    Watanabe J, Ota M, Suwa Y, Suzuki S, Suwa H, Momiyama M, Ishibe A, Watanabe K, Masui H, Nagahori K, Ichikawa Y, Endo I. Evaluation of the intestinal blood flow near the rectosigmoid junction using the indocyanine green fluorescence method in a colorectal cancer surgery. Int J Colorectal Dis. 2015;30(3):329–35.PubMedCrossRefGoogle Scholar
  206. 206.
    Kim JC, Lee JL, Yoon YS, Alotaibi AM, Kim J. Utility of indocyanine-green fluorescent imaging during robot-assisted sphincter-saving surgery on rectal cancer patients. Int J Med Robotics Comput Assist Surg. 2015 Oct 21 [E-pub].Google Scholar
  207. 207.
    Ye F, Chen D, Wang D, Lin J, Zheng S. Use of Valtrac™-secured intracolonic bypass in laparoscopic rectal cancer resection. Medicine. 2014;93(29):e224.PubMedPubMedCentralCrossRefGoogle Scholar
  208. 208.
    Cossu ML, Coppola M, Fais E, Ruggiu M, Spartà C, Profili S, Bifulco V, Meloni GB, Noya G. The use of the Valtrac ring in the upper and lower gastrointestinal tract, for single, double, and triple anastomoses: a report of 50 cases. Am Surg. 2000;66(8):759–62.PubMedGoogle Scholar
  209. 209.
    Masoomi H, Luo R, Mills S, Carmichael JC, Senagore AJ, Stamos MJ. Compression anastomosis ring device in colorectal anastomosis: a review of 1,180 patients. Am J Surg. 2013;205(4):447–51.PubMedCrossRefGoogle Scholar
  210. 210.
    Senagore A, Lane FR, Lee E, Wexner S, Dujovny N, Sklow B, Rider P, Bonello J. Bioabsorbable Staple Line Reinforcement in Restorative Proctectomy and Anterior Resection. Dis Colon Rectum. 2014;57(3):324–30.PubMedCrossRefGoogle Scholar
  211. 211.
    Placer C, Enríquez-Navascués JM, Elorza G, Timoteo A, Mugica JA, Borda N, Saralegui Y, Elósegui JL. Preventing complications in colorectal anastomosis: results of a randomized controlled trial using bioabsorbable staple line reinforcement for circular stapler. Dis Colon Rectum. 2014;57(10):1195–201.PubMedCrossRefGoogle Scholar
  212. 212.
    Ris F, Hompes R, Cunningham C, Lindsey I, Guy R, Jones O, George B, Cahill RA, Mortensen NJ. Near-infrared (NIR) perfusion angiography in minimally invasive colorectal surgery. Surg Endosc. 2014;28(7):2221–6.PubMedPubMedCentralCrossRefGoogle Scholar
  213. 213.
    Kin C, Vo H, Welton L, Welton M. Equivocal Effect of Intraoperative Fluorescence Angiography on Colorectal Anastomotic Leaks. Dis Colon Rectum. 2015;58(6):582–7.PubMedCrossRefGoogle Scholar
  214. 214.
    Jafari MD, Wexner SD, Martz JE, McLemore EC, Margolin DA, Sherwinter DA, Lee SW, Senagore AJ, Phelan MJ, Stamos MJ. Perfusion Assessment in Laparoscopic Left-Sided/Anterior Resection (PILLAR II): A Multi-Institutional Study. J Am Coll Surg. 2015;220(1):82–92.e1.Google Scholar
  215. 215.
    Ravo B, Ger R. Temporary colostomy-an outmoded procedure? A report on the intracolonic bypass. Dis Colon Rectum. 1985;28(12):904–7.PubMedCrossRefGoogle Scholar

Copyright information

© The Society for Surgery of the Alimentary Tract 2016

Authors and Affiliations

  • Sami A. Chadi
    • 1
    • 2
    • 3
  • Abe Fingerhut
    • 4
    • 5
  • Mariana Berho
    • 6
  • Steven R. DeMeester
    • 7
  • James W. Fleshman
    • 8
  • Neil H. Hyman
    • 9
  • David A. Margolin
    • 10
  • Joseph E. Martz
    • 11
  • Elisabeth C. McLemore
    • 12
  • Daniela Molena
    • 13
  • Martin I. Newman
    • 14
  • Janice F. Rafferty
    • 15
  • Bashar Safar
    • 16
  • Anthony J. Senagore
    • 17
  • Oded Zmora
    • 18
  • Steven D. Wexner
    • 1
    Email author
  1. 1.Department of Colorectal SurgeryCleveland Clinic FloridaWestonUSA
  2. 2.Division of General SurgeryUniversity Health NetworkTorontoCanada
  3. 3.Department of SurgeryUniversity of TorontoTorontoCanada
  4. 4.Section for Surgical Research, Department of SurgeryMedical University of GrazGrazAustria
  5. 5.First Department of Surgery, Hippokration University HospitalUniversity of AthensAthensGreece
  6. 6.Department of PathologyCleveland Clinic FloridaWestonUSA
  7. 7.Department of Surgery, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  8. 8.Department of SurgeryBaylor University Medical Center at DallasDallasUSA
  9. 9.Department of SurgeryUniversity of Chicago MedicineChicagoUSA
  10. 10.Department of Colon and Rectal SurgeryOchsner Clinic FoundationNew OrleansUSA
  11. 11.Division of Colorectal SurgeryMount Sinai Beth IsraelNew YorkUSA
  12. 12.Department of Surgery, Colorectal SurgeryKaiser Permanente Los Angeles Medical CenterLos AngelesUSA
  13. 13.Division of Thoracic Surgery, Department of SurgeryJohns Hopkins UniversityBaltimoreUSA
  14. 14.Department of Plastic and Reconstructive SurgeryCleveland Clinic FloridaWestonUSA
  15. 15.Department of SurgeryUniversity of Cincinnati College of MedicineCincinnatiUSA
  16. 16.Department of SurgeryJohns Hopkins University School of MedicineBaltimoreUSA
  17. 17.Department of Surgery, School of MedicineCase Western Reserve UniversityClevelandUSA
  18. 18.Department of Surgery, Sackler School of MedicineSheba Medical CenterTel AvivIsrael

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