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Journal of Gastrointestinal Surgery

, Volume 20, Issue 3, pp 587–594 | Cite as

Hepatic Hemodynamic Changes Following Stepwise Liver Resection

  • Mohammad Golriz
  • Saroa El Sakka
  • Ali Majlesara
  • Arman Edalatpour
  • Mohammadreza Hafezi
  • Nahid Rezaei
  • Camelia Garoussi
  • Jalal Arwin
  • Arash Saffari
  • Hanna Raisi
  • Arezou Abbasi
  • Arianeb MehrabiEmail author
Original Article

Abstract

Aim

Extended liver resection has increased during the last decades. However, hepatic hemodynamic changes after resection and the consequent complications like post hepatectomy liver failure are still a challenging issue. The aim of this study was to systematically evaluate the role of stepwise liver resection on hepatic hemodynamic changes.

Methods

To evaluate this effect we performed 25, 50, and 75 % sequential liver resections in 10 pigs. Before and after each resection, the hepatic artery flow and portal vein flow in relation to the remnant liver volume (RLV) as well as hepatic vascular pressures were measured and compared between the groups.

Results

Following sequential liver resection, the hepatic artery flow /100 g decreases and the portal vein flow increases up to 17 and 167 % following extended liver resection (75 %), respectively. Also, during stepwise liver resection, the portal vein pressure increases gradually up to 33 % following extended hepatectomy (75 %).

Conclusion

Sequential decrease in the RLV decreases the hepatic artery flow /100 g and increases the portal vein flow /100 g and portal vein pressure. As the consequence, the liver goes under more poor-oxygenated blood supply and higher pressure. This may be one of the most important mechanisms of the post hepatectomy liver failure in case of extended liver resection.

Keywords

Hepatectomy Portal vein Hepatic artery 

Notes

Acknowledgments

This work was supported by the German Research Foundation (DFG) as a part of project A02-SFB/TRR 125 Cognition-Guided Surgery.

Compliance with Ethical Standards

Disclosure

All the authors declared no potential conflicts of interests with respect to the authorship and/or publication of this article. There was no sponsorship or funding arrangements relating to this research and the authors of this work have no financial and personal relationships with other people or organizations that could potentially and inappropriately influence their work and conclusions.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2015

Authors and Affiliations

  • Mohammad Golriz
    • 1
  • Saroa El Sakka
    • 1
  • Ali Majlesara
    • 1
  • Arman Edalatpour
    • 1
  • Mohammadreza Hafezi
    • 1
  • Nahid Rezaei
    • 1
  • Camelia Garoussi
    • 1
  • Jalal Arwin
    • 1
  • Arash Saffari
    • 1
  • Hanna Raisi
    • 1
  • Arezou Abbasi
    • 1
  • Arianeb Mehrabi
    • 1
    Email author
  1. 1.Department of General, Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany

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