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Journal of Gastrointestinal Surgery

, Volume 19, Issue 8, pp 1522–1527 | Cite as

Variations in Metastasis Site by Primary Location in Colon Cancer

  • Ramzi Amri
  • Liliana G. Bordeianou
  • Patricia Sylla
  • David L. BergerEmail author
Original Article

Abstract

Objective

The purpose of this paper is to determine whether sites of distant recurrence are associated with specific locations of primary disease in colon cancer.

Methods

A cohort including all patients (n = 947) undergoing a segmental colonic resection for colon cancer at our center (2004–2011) comparing site-specific metastatic presentation and recurrence rates, as well as their respective multivariable American Joint Committee on Cancer (AJCC) stage-adjusted hazard ratios (mHR).

Results

Right-sided colectomies (n = 557) had a lower overall metastasis rate (24.8 % vs. 31.8 %; P = 0.017; mHR = 1.24 [95% CI: 0.96–1.60]; P = 0.011) due to significantly lower pulmonary metastasis in follow-up (2.7 % vs. 9 %; P < 0.001; mHR = 0.32 [95% CI: 0.17–0.58]; P = 0.001) and lower overall liver metastasis rate (15.6 vs. 22.1 %; P = 0.012; mHR = 0.74 [95% CI: 0.55–0.99];P = 0.050). Left colectomies (n = 127) had higher rates of liver metastasis during follow-up (9.4 % vs. 4.8 %; P = 0.029; mHR = 1.64 [95% CI: 0.86–3.15]; P = 0.134). Sigmoid resections (n = 238) had higher baseline rates of liver metastasis (17.1 % vs. 11.3 %; P = 0.015) and higher cumulative rates of lung (12.2 % vs. 5.4 %; P < 0.001; mHR = 2.26 [95 % CI: 1.41–3.63]; P = 0.001) and brain metastases (2.3 % vs. 0.6 %; P = 0.033; mHR = 4.03 [95% CI: 1.14–14.3]; P = 0.031). Other sites of metastasis, including the (retro) peritoneum, omentum, ovary, and bone, did not yield significant differences.

Conclusions

Important variations in site-specific rates of metastatic disease exist within major resection regions of colon cancer. These variations may be important to consider when evaluating options for adjuvant treatment and surveillance after resection of the primary disease.

Keywords

Colon cancer Metastasis site Metastatic patterns Outcomes Primary disease site 

Notes

Conflicts of Interest

None of the authors have conflicts of interest. DB had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Funding and support

This work was conducted with support from the Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award 8UL1TR000170-05, and financial contributions from the Harvard University and its affiliated academic health care centers). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University, and its affiliated academic health care centers, or the National Institutes of Health.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2015

Authors and Affiliations

  • Ramzi Amri
    • 1
  • Liliana G. Bordeianou
    • 1
  • Patricia Sylla
    • 2
  • David L. Berger
    • 1
    Email author
  1. 1.Division of General and Gastrointestinal SurgeryMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Colon and Rectal SurgeryIcahn School of Medicine, Mount Sinai HospitalNew YorkUSA

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