Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus
Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.
AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.
There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).
Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.
KeywordsPostoperative Ileus Biosensor Health technology
- 7.Andersen HK, Lewis SJ, Thomas S. Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev 2006:CD004080.Google Scholar
- 10.Wolff BG, Viscusi ER, Delaney CP, Senagore AJ, Fort JG, Du W, Techner L, Wallin B. Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials. J Am Coll Surg 2007;205:43–51.PubMedCrossRefGoogle Scholar
- 13.Barletta JF, Senagore AJ. Reducing the Burden of Postoperative ileus: Evaluating and Implementing an Evidence-based Strategy. World J Surg 2014.Google Scholar
- 19.Au LK, Batalin MA, Stathopoulos T, Bui AA, Kaiser WJ. Episodic sampling: towards energy-efficient patient monitoring with wearable sensors. Conf Proc IEEE Eng Med Biol Soc 2009;2009:6901–5.Google Scholar
- 20.Xu JY, Chang HI, Chien C, Kaiser WJ, Pottie GJ. Context-driven, Prescription based Personal Activity Classification: Methodology, Architecture and End-to-End Implementation. IEEE J Biomed Health Inform 2013.Google Scholar