Journal of Gastrointestinal Surgery

, Volume 18, Issue 7, pp 1327–1333 | Cite as

Risk Factors of Postoperative Upper Gastrointestinal Bleeding Following Colorectal Resections

  • Zhobin Moghadamyeghaneh
  • Steven D. Mills
  • Alessio Pigazzi
  • Joseph C. Carmichael
  • Michael J. Stamos
Original Article


There is limited data regarding the risk factors of postoperative upper GI bleeding (UGIB) in patients undergoing colorectal resection. We sought to identify risk factors of UGIB after colorectal resection. The NIS database was used to evaluate all patients who had colorectal resection complicated by UGIB between 2002 and 2010. Multivariate analysis using logistic regression was performed to quantify the association of preoperative variables with postoperative UGIB. We sampled a total of 2,514,228 patients undergoing colorectal resection, of which, 12,925 (0.5 %) suffered a postoperative UGIB. The mortality of patients who had UGIB was significantly greater than patients without UGIB (14.9 vs. 4.7 %; OR, 3.57; CI, 3.40–3.75; P < 0.01). Patients suffering from UGIB had an associated 14.9 % inhospital mortality. History of chronic peptic ulcer disease (6.75; CI, 5.75–7.91; P < 0.01) and emergency admission (OR, 4.27; CI, 4.09–4.45; P < 0.01) are associated with UGIB. Duodenal ulcer as the source of bleeding is a mortality predictors of patients (OR, 1.71; CI, 1.49–1.97; P < 0.01). Postoperative UGIB occurs in less than 1 % of colorectal resections. However, patients suffering from postoperative UGIB are over three times more likely to die. Chronic peptic ulcer disease and emergency admission are respectively the strongest predictors of postoperative UGIB.


Gastrointestinal bleeding Colorectal surgery Postoperative bleeding 



Upper gastrointestinal bleeding


Nationwide inpatient sample


International Classification of Diseases, 9th Revision, Clinical Modifications


Odds ratio


Discharge weight


Conflict of Interest

The authors declare no potential conflicts of interest.

Financial Disclosure



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Copyright information

© The Society for Surgery of the Alimentary Tract 2014

Authors and Affiliations

  • Zhobin Moghadamyeghaneh
    • 1
  • Steven D. Mills
    • 1
  • Alessio Pigazzi
    • 1
  • Joseph C. Carmichael
    • 1
  • Michael J. Stamos
    • 1
    • 2
  1. 1.Department of Surgery, School of MedicineUniversity of California, IrvineOrangeUSA
  2. 2.OrangeUSA

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