Journal of Gastrointestinal Surgery

, Volume 17, Issue 7, pp 1224–1232 | Cite as

Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors

  • Sven-Petter Haugvik
  • Knut Jørgen Labori
  • Anne Waage
  • Pål-Dag Line
  • Øystein Mathisen
  • Ivar Prydz Gladhaug
Original Article
First Online:
Received:
Accepted:

Abstract

Introduction

Pancreatic neuroendocrine tumors (PNET) are rare neoplasms with better prognosis than most pancreatic malignancies. Surgery of locally advanced PNET remains controversial, and the role of vascular reconstruction in this patient group has yet to be defined. The aim of this study was to evaluate the feasibility and outcome of pancreatic resections with vascular reconstruction in patients with locally advanced PNET.

Methods

Retrospective analysis of patients who underwent pancreatic surgery with vascular reconstruction for locally advanced PNET at a single institution. Furthermore, a review of the relevant literature on the topic was performed.

Results

Seven patients who had undergone vascular reconstruction for locally advanced PNET were identified. Four patients had liver metastases at time of surgery. Postoperative complications developed in four patients with no mortality. Median follow-up time of all patients was 21 (range, 3–58) months. Three patients had disease in remission after 58, 42 and 3 months, respectively. One patient died 35 months postoperatively due to progressive disease, whereas three patients had progression of disease after 21, 9, and 4 months postoperatively.

Conclusion

Pancreatic surgery with vascular reconstruction in patients with locally advanced PNET is feasible with acceptable outcome.

Keywords

PNET Neuroendocrine Pancreatic surgery Vascular reconstruction Pancreas 
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Notes

Sources of support

The sources of support behind this study came from Oslo University Hospital. There were no other sources of support and no other funding.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2013

Authors and Affiliations

  • Sven-Petter Haugvik
    • 1
    • 2
  • Knut Jørgen Labori
    • 1
  • Anne Waage
    • 1
  • Pål-Dag Line
    • 3
  • Øystein Mathisen
    • 1
  • Ivar Prydz Gladhaug
    • 1
    • 2
  1. 1.Department of Hepato-Pancreato-Biliary Surgery, RikshospitaletOslo University HospitalOsloNorway
  2. 2.Institute of Clinical MedicineUniversity of OsloOsloNorway
  3. 3.Department of Organ Transplantation, RikshospitaletOslo University HospitalOsloNorway

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