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Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Pancreatic neuroendocrine tumors (PNET) are rare neoplasms with better prognosis than most pancreatic malignancies. Surgery of locally advanced PNET remains controversial, and the role of vascular reconstruction in this patient group has yet to be defined. The aim of this study was to evaluate the feasibility and outcome of pancreatic resections with vascular reconstruction in patients with locally advanced PNET.

Methods

Retrospective analysis of patients who underwent pancreatic surgery with vascular reconstruction for locally advanced PNET at a single institution. Furthermore, a review of the relevant literature on the topic was performed.

Results

Seven patients who had undergone vascular reconstruction for locally advanced PNET were identified. Four patients had liver metastases at time of surgery. Postoperative complications developed in four patients with no mortality. Median follow-up time of all patients was 21 (range, 3–58) months. Three patients had disease in remission after 58, 42 and 3 months, respectively. One patient died 35 months postoperatively due to progressive disease, whereas three patients had progression of disease after 21, 9, and 4 months postoperatively.

Conclusion

Pancreatic surgery with vascular reconstruction in patients with locally advanced PNET is feasible with acceptable outcome.

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Sources of support

The sources of support behind this study came from Oslo University Hospital. There were no other sources of support and no other funding.

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Authors and Affiliations

  1. Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway

    Sven-Petter Haugvik, Knut Jørgen Labori, Anne Waage, Øystein Mathisen & Ivar Prydz Gladhaug

  2. Institute of Clinical Medicine, University of Oslo, Oslo, Norway

    Sven-Petter Haugvik & Ivar Prydz Gladhaug

  3. Department of Organ Transplantation, Rikshospitalet, Oslo University Hospital, Oslo, Norway

    Pål-Dag Line

Authors
  1. Sven-Petter Haugvik
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  2. Knut Jørgen Labori
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  3. Anne Waage
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  4. Pål-Dag Line
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  5. Øystein Mathisen
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Correspondence to Sven-Petter Haugvik.

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Haugvik, SP., Labori, K.J., Waage, A. et al. Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors. J Gastrointest Surg 17, 1224–1232 (2013). https://doi.org/10.1007/s11605-013-2221-6

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  • DOI: https://doi.org/10.1007/s11605-013-2221-6

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