Journal of Gastrointestinal Surgery

, Volume 17, Issue 8, pp 1526–1535

The Pulmonary Side of Reflux Disease: from Heartburn to Lung Fibrosis

  • Marco E. Allaix
  • P. Marco Fisichella
  • Imre Noth
  • Bernardino M. Mendez
  • Marco G. Patti
Review Article



Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder in the USA. Heartburn is the symptom most commonly associated with this disease, and the highly commercialized medical treatment directed toward relief of this symptom represents a 10-billion-dollar-per-year industry.


Unfortunately, there is often little awareness that GERD can be potentially a lethal disease as it can cause esophageal cancer. Furthermore, there is even less awareness about the relationship between GERD and respiratory disorders with the potential for severe morbidity and even mortality.


Gastroesophageal reflux disease Lower esophageal sphincter Esophageal peristalsis Hiatal hernia Obesity Esophageal manometry Ambulatory pH monitoring Idiopathic pulmonary fibrosis Lung transplantation Laparoscopic Nissen fundoplication 


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Copyright information

© The Society for Surgery of the Alimentary Tract 2013

Authors and Affiliations

  • Marco E. Allaix
    • 1
  • P. Marco Fisichella
    • 2
  • Imre Noth
    • 3
  • Bernardino M. Mendez
    • 2
  • Marco G. Patti
    • 1
  1. 1.Center for Esophageal Diseases, Department of SurgeryUniversity of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Swallowing Center, Department of SurgeryLoyola UniversityChicagoUSA
  3. 3.Center for Esophageal Diseases, Department of MedicineUniversity of Chicago Pritzker School of MedicineChicagoUSA

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