Journal of Gastrointestinal Surgery

, Volume 17, Issue 1, pp 21–29 | Cite as

Prior Fundoplication Does not Improve Safety or Efficacy Outcomes of Radiofrequency Ablation: Results from the U.S. RFA Registry

  • Nicholas J. Shaheen
  • Hannah P. Kim
  • William J. Bulsiewicz
  • William D. Lyday
  • George Triadafilopoulos
  • Herbert C. Wolfsen
  • Srinadh Komanduri
  • Gary W. Chmielewski
  • Atilla Ertan
  • F. Scott Corbett
  • Daniel S. Camara
  • Richard I. Rothstein
  • Bergein F. Overholt
2012 SSAT Plenary Presentation

Abstract

Background

Ongoing gastroesophageal reflux may impair healing and re-epithelialization after radiofrequency ablation (RFA) of Barrett’s esophagus (BE). Because prior fundoplication may improve reflux control, our aim was to assess the relationship between prior fundoplication and the safety/efficacy of RFA.

Methods

We assessed the U.S. RFA Registry, a nationwide registry of BE patients receiving RFA at 148 institutions, to compare the safety and efficacy of ablation between those with prior fundoplication and those with medical management (proton pump inhibition).

Results

Among 5,537 patients receiving RFA, 301 (5.4 %) had prior fundoplication. Of fundoplication subjects, 1.0 % developed stricture and 1.0 % were hospitalized after RFA. Rates of stricture, bleeding, and hospitalization were not statistically different (p = ns) between patients with and without prior fundoplication. Complete eradication of intestinal metaplasia and complete eradication of dysplasia were achieved in 71 % and 87 % of fundoplication patients, and 73 % and 87 % of patients without fundoplication, respectively (p = ns for both). Patients with prior fundoplication needed similar numbers of RFA sessions for eradication compared with those without fundoplication.

Conclusions

Radiofrequency ablation, with or without prior fundoplication, is safe and effective in eradicating BE. Prior fundoplication was associated with similar adverse event and efficacy rates when compared with medical management.

Keywords

Barrett’s esophagus Radiofrequency ablation Fundoplication Safety Efficacy 

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Copyright information

© The Society for Surgery of the Alimentary Tract 2012

Authors and Affiliations

  • Nicholas J. Shaheen
    • 1
  • Hannah P. Kim
    • 1
  • William J. Bulsiewicz
    • 1
  • William D. Lyday
    • 2
  • George Triadafilopoulos
    • 3
  • Herbert C. Wolfsen
    • 4
  • Srinadh Komanduri
    • 5
  • Gary W. Chmielewski
    • 6
  • Atilla Ertan
    • 7
  • F. Scott Corbett
    • 8
  • Daniel S. Camara
    • 9
  • Richard I. Rothstein
    • 10
  • Bergein F. Overholt
    • 11
  1. 1.University of North Carolina School of MedicineChapel HillUSA
  2. 2.Atlanta Gastroenterology AssociatesAtlantaUSA
  3. 3.Stanford University School of MedicinePalo AltoUSA
  4. 4.Mayo Clinic FloridaJacksonvilleUSA
  5. 5.Northwestern University School of MedicineChicagoUSA
  6. 6.William Beaumont HospitalDetroitUSA
  7. 7.University of Texas Medical SchoolHoustonUSA
  8. 8.Gastroenterology Associates of SarasotaSarasotaUSA
  9. 9.Digestive Health PhysiciansCheektowagaUSA
  10. 10.Dartmouth University School of MedicineHanoverUSA
  11. 11.Gastrointestinal AssociatesKnoxvilleUSA

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