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Journal of Gastrointestinal Surgery

, Volume 16, Issue 9, pp 1715–1726 | Cite as

Clinicopathological Characteristics and Outcome of Primary Sarcomatoid Carcinoma and Carcinosarcoma of the Liver

  • Qi-Bo Wang
  • Bo-Kang Cui
  • Jian-Ming Weng
  • Qiu-Liang Wu
  • Ji-Liang Qiu
  • Xiao-Jun Lin
Original Article

Abstract

Background

Primary sarcomatoid carcinoma (SC) and carcinosarcoma (CS) of the liver are rare tumors.

Patients and Methods

From November 1999 to June 2011, clinicopathological features and outcome of 10 SC and 14 CS patients were retrospectively studied.

Results

In the SC group, six patients had hepatocellular carcinoma and four had cholangiocellular carcinoma, while in the CS group, it was nine and five patients, respectively. All cases of the sarcomatous components were vimentin-positive. Pan-cytokeratin were stained in sarcomatous components of the SC group, but not in the CS group. The sarcomatous component in the SC group was negative for desmin, myoglobin, HHF35, SMA, CD68, Mac387, AAT, CD34, and S100. In the CS group, the sarcomatous components in six cases were malignant fibrous histiocytomas, six were fibrosarcomas, and two were rhabdomyosarcomas. Median survival times were 9.6 and 4.8 months for the SC and CS groups, respectively (P = 0.483). In univariate analysis, favorable predictors of overall survival were asymptomatic, Child–Pugh class A, no distant metastasis, and radical resection.

Conclusions

SC and CS were highly aggressive malignancies with similar poor survival regardless of the histological and immunohistochemical findings. Early detection through regular physical examination and treatment with radical resection may improve the outcome of those patients.

Keywords

Liver Sarcomatoid carcinoma Carcinosarcoma Prognosis Survival 

Notes

Acknowledgments

The authors thank Muyan Cai, Shaoyan Xi, and Xiaopai Wang (Department of Pathology, Sun Yat-Sen University) for their help in reviewing the pathology slides and for their valuable comments during the preparation of this manuscript.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2012

Authors and Affiliations

  • Qi-Bo Wang
    • 1
    • 2
  • Bo-Kang Cui
    • 1
    • 2
  • Jian-Ming Weng
    • 3
  • Qiu-Liang Wu
    • 2
    • 4
  • Ji-Liang Qiu
    • 1
    • 2
  • Xiao-Jun Lin
    • 1
    • 2
  1. 1.Department of Hepatobiliary SurgeryCancer Center of Sun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  2. 2.State Key Laboratory of Oncology in Southern ChinaGuangzhouChina
  3. 3.Department of PathologyZhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouChina
  4. 4.Department of PathologyCancer Center of Sun Yat-Sen UniversityGuangzhouChina

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