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Journal of Gastrointestinal Surgery

, Volume 16, Issue 7, pp 1287–1295 | Cite as

Randomized Trial Comparing Side-to-Side Stapled and Hand-Sewn Esophagogastric Anastomosis in Neck

  • Sundeep Singh Saluja
  • Sukanta Ray
  • Sujoy Pal
  • Sumit Sanyal
  • Nikhil Agrawal
  • Nihar Ranjan Dash
  • Peush Sahni
  • Tushar Kanti Chattopadhyay
Original Article

Abstract

Background

Leak from cervical esophagogastric anastomosis (CEGA) following esophagectomy is associated with morbidity and poor functional outcome. To address this issue, we conducted a randomized trial comparing “hand-sewn” with “stapled side-to-side” CEGA.

Methods

Of 174 patients who underwent esophageal resection and CEGA between 2004 and 2010, 87 each were randomized to “hand-sewn” and “stapled side-to-side” CEGA [www.Clinical Trials.gov: NCT00497549]. The primary outcome measure was anastomotic leak rate. The secondary outcome measures included CEGA construction time and occurrence of anastomotic stricture during follow up.

Results

The overall anastomotic leak rate was 17.2 % (major leaks: 8 %). The leak rate was similar among the two groups (hand-sewn: 14/87, stapled: 16/87; p = 0.33). The stapled anastomotic technique was faster (25 ± 6.5 min vs. 27 ± 5.5 min; p = 0.02). The overall operative mortality and morbidity rates were 6.3 % and 40.8 %, respectively. At a median follow up of 12 (6–42) months, anastomotic stricture occurred in 24 (14.7 %) patients and was significantly more common in the “hand-sewn” group (17/82 vs. 7/81; p = 0.045).

Conclusion

There were no differences in the leak rates and postoperative outcome between the two CEGA techniques. At follow up, anastomotic strictures occurred less frequently following stapled CEGA. The ideal CEGA technique remains elusive.

Keywords

Hand-sewn anastomosis Side-to-side stapled anastomosis Cervical esophagogastric anastomosis Esophagectomy Carcinoma esophagus 

Notes

Source of funding

None

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Copyright information

© The Society for Surgery of the Alimentary Tract 2012

Authors and Affiliations

  • Sundeep Singh Saluja
    • 1
  • Sukanta Ray
    • 1
  • Sujoy Pal
    • 1
  • Sumit Sanyal
    • 1
  • Nikhil Agrawal
    • 1
  • Nihar Ranjan Dash
    • 1
  • Peush Sahni
    • 1
  • Tushar Kanti Chattopadhyay
    • 1
  1. 1.Department of Gastrointestinal SurgeryAll India Institute of Medical SciencesAnsari NagarIndia

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