Intensive Versus Conventional Insulin Therapy in Nondiabetic Patients Receiving Parenteral Nutrition After D2 Gastrectomy for Gastric Cancer: A Randomized Controlled Trial

  • Shougen Cao
  • Yanbing Zhou
  • Dong Chen
  • Zhaojian Niu
  • Dongsheng Wang
  • Liang Lv
  • Yu Li
Original Article



This study was used to compare the effects of intensive insulin therapy with conventional insulin therapy on postoperative outcomes among nondiabetic patients receiving parenteral nutrition following D2 gastrectomy for gastric cancer.


A total of 248 eligible patients were randomly assigned to receive intensive insulin therapy targeting a blood glucose level between 4.4 and 6.1 mmol/l [intensive group (n = 125)] or conventional insulin therapy targeting a blood glucose level less than 11.0 mmol/l [conventional group (n = 123)] during the postoperative period.


Mean blood glucose concentrations were lower in the intensive group than in the conventional group. Severe hypoglycemia defined as blood glucose ≤2.2 mmol/l occurred in eight (6.4%) patients in the intensive group vs one (0.8%) patient in the conventional group (P = 0.036). One (0.8%) patient died in the intensive group vs two (1.6%) patients in the conventional group (P = 0.620). However, intensive insulin therapy significantly reduced overall postoperative complications rate (from 25.2% to 13.6%, P = 0.024). Moreover, both insulin resistance indicated as HOMA-IR and HLA-DR expression on monocytes were improved in the intensive group.


Intensive insulin therapy significantly reduced the postoperative short-term morbidity but not mortality among nondiabetic patients receiving parenteral nutrition after D2 gastrectomy. The benefits may be due to the suppression of insulin resistance and improvement of HLA-DR expression on monocytes.


Intensive insulin therapy Gastric cancer Parenteral nutrition Insulin resistance HLA-DR Postoperative complications 


Grant Support

This study was supported by the Health Science and Technology Development Project of Shandong (2005HZ024).

Conflict of interest

There is no potential and real conflict to any third party.


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Copyright information

© The Society for Surgery of the Alimentary Tract 2011

Authors and Affiliations

  • Shougen Cao
    • 1
  • Yanbing Zhou
    • 1
  • Dong Chen
    • 1
  • Zhaojian Niu
    • 1
  • Dongsheng Wang
    • 1
  • Liang Lv
    • 1
  • Yu Li
    • 1
  1. 1.Department of General SurgeryAffiliated Hospital of Medical College Qingdao UniversityQingdaoChina

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