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Journal of Gastrointestinal Surgery

, Volume 15, Issue 9, pp 1594–1601 | Cite as

Convergence Process of Volumetric Liver Regeneration After Living-Donor Hepatectomy

  • Taku Aoki
  • Hiroshi ImamuraEmail author
  • Yutaka Matsuyama
  • Yoji Kishi
  • Takashi Kobayashi
  • Yasuhiko Sugawara
  • Masatoshi Makuuchi
  • Norihiro Kokudo
Original Article

Abstract

Background

We investigated the long-term profiles of liver regeneration after living-donor hepatectomy.

Methods

Thirty-three donors participated in the study. Preoperative and postoperative liver volume was calculated using computed tomography. Volume assessment was repeated at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months, and 4 years postoperatively.

Results

Donors were divided into the right (n = 23; residual liver volume, 42%) and left (n = 10; residual liver volume, 63%) groups according to the operative procedures. The restoration ratio to the preoperative liver volume (right vs. left groups) were 51%, 57%, 64%, 74%, 77%, 81%, and 88% vs. 69%, 72%, 76%, 79%, 83%, 84%, and 91% at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months, and 4 years, respectively; the interindividual variation in the restoration ratio to the preoperative liver volume became narrower with time.

Conclusion

Liver resection in humans resulted in rapid regeneration during the first 3 months, followed by a more moderate rate of regeneration thereafter, in proportion to the amount of liver mass resected. The volume of the regenerating liver appeared to converge towards the individual preoperative volume with time. However, the liver volume was not restored to the preoperative volume at 4 years after the resection.

Keywords

CT volumetry Donor hepatectomy Liver regeneration Total liver volume 

Abbreviations

ALB

Albumin

LDLT

Living-donor liver transplantation

TLV

Total liver volume

CT

Computed tomography

ICG

Indocyanine green

BMI

Body mass index

TB

Total bilirubin

AST

Aspartate aminotransferase

ALT

Alanine aminotransferase

PT-INR

Prothrombin time international normalized ratio

ICG R15

ICG retention rate at 15 min

Notes

Funding/Support

This study was supported in part by a Grant-in-Aid for Scientific Research (B) (20390352).

Financial Disclosure

None reported.

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Copyright information

© The Society for Surgery of the Alimentary Tract 2011

Authors and Affiliations

  • Taku Aoki
    • 1
  • Hiroshi Imamura
    • 1
    • 3
    Email author
  • Yutaka Matsuyama
    • 2
  • Yoji Kishi
    • 1
  • Takashi Kobayashi
    • 1
  • Yasuhiko Sugawara
    • 1
  • Masatoshi Makuuchi
    • 1
  • Norihiro Kokudo
    • 1
  1. 1.Division of Hepato-Biliary-Pancreatic and Transplantation Surgery, Department of Surgery, Graduate School of MedicineUniversity of TokyoTokyoJapan
  2. 2.Department of Biostatistics, Graduate School of MedicineUniversity of TokyoTokyoJapan
  3. 3.Department of Hepatobiliary-Pancreatic SurgeryJuntendo School of MedicineTokyoJapan

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