Journal of Gastrointestinal Surgery

, Volume 15, Issue 8, pp 1361–1367

Mosapride Citrate Improves Postoperative Ileus of Patients with Colectomy

  • Yoshitaka Toyomasu
  • Erito Mochiki
  • Hiroki Morita
  • Atsushi Ogawa
  • Mitsuhiro Yanai
  • Tetsuro Ohno
  • Takaaki Fujii
  • Soichi Tsutsumi
  • Takayuki Asao
  • Hiroyuki Kuwano
Original Article

Abstract

Background and Aims

Postoperative ileus is a transient bowel dysmotility that occurs following many types of operations and is a common complication of gastrointestinal surgery. Mosapride citrate is an agonist of the 5-hydroxytryptamine 4 receptor and accelerates upper gut motility. No study has evaluated its effect on gastrointestinal motility after surgery. The aim of this study was to investigate whether mosapride citrate reduces the duration of postoperative ileus.

Methods

Thirty patients with colon cancer who underwent colectomy were divided into two groups: the mosapride group and the control group. The mosapride group received mosapride 15 mg by mouth with a minimal amount of water three times a day, starting on postoperative day 1. The control group received only a minimal amount of water on the same schedule. Patients were allowed to resume oral feeding on postoperative day 4. Postoperative time to first flatus and defecation were evaluated, and the amount of food intake was observed. Gastrointestinal motility was recorded on postoperative day 8.

Results

The appearance ratio of interdigestive migrating contractions and the motility index at the antrum and duodenum were significantly higher in the mosapride group than in the control group. The time to first flatus and defecation were significantly shorter in the mosapride group than in the control group. The amount of food intake on postoperative days 6 and 7 was significantly larger in the mosapride group than in the control group.

Conclusion

Mosapride citrate reduces the duration of postoperative ileus and may improve outcomes after gastrointestinal surgery.

Keywords

Gastrointestinal motility Transducer Interdigestive migrating motor contractions 

Abbreviations

IMC

Interdigestive migrating motor contractions

MI

Motility index

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Copyright information

© The Society for Surgery of the Alimentary Tract 2011

Authors and Affiliations

  • Yoshitaka Toyomasu
    • 1
  • Erito Mochiki
    • 1
  • Hiroki Morita
    • 1
  • Atsushi Ogawa
    • 1
  • Mitsuhiro Yanai
    • 1
  • Tetsuro Ohno
    • 1
  • Takaaki Fujii
    • 1
  • Soichi Tsutsumi
    • 1
  • Takayuki Asao
    • 1
  • Hiroyuki Kuwano
    • 1
  1. 1.Department of General Surgical Science (Surgery I), Graduate School of MedicineGunma UniversityMaebashiJapan

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