Journal of Gastrointestinal Surgery

, Volume 15, Issue 2, pp 311–320

Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases

  • Jiwei Huang
  • Roberto Hernandez-Alejandro
  • Kristopher P. Croome
  • Lvnan Yan
  • Hong Wu
  • Zheyu Chen
  • Pankaj Prasoon
  • Yong Zeng
Original Article



The long-term outcomes of radiofrequency ablation (RFA) vs. surgical resection in cirrhotic patients with hepatocellular carcinoma (HCC) remain controversial. One thousand sixty-one cirrhotic HCC patients were included into a retrospective study. Four hundred thirteen received RFA and 648 received surgical resection.


Overall (OS), recurrence-free (RFS), and tumor-free survival (TFS) were compared between the two groups and in subgroup analyses. The 5-year OS and corresponding RFS as well as DFS were significantly higher in the surgical resection group compared with the RFA group (p < 0.001, p < 0.001, p < 0.001). In subgroup analyses of solitary HCC ≤3 cm, there was no significant difference in RFS between the two groups (p = 0.719). Nonetheless, surgical resection was superior to RFA for OS and TFS in this subgroup as well as for OS, RFS, and TFS in subgroup analyses for solitary lesions 3 cm < HCC < 5 cm and multifocal HCC. Serum AFP was the only significant predicting factor for all survival analyses.


When treating Childs A cirrhotic patients with solitary HCC larger than 3 cm but less than 5 cm, or with two or three lesions each less than 5 cm, surgical resection provides a better survival than RFA. When treating Childs A cirrhotics with solitary HCC ≤ 3 cm, RFA has a comparable RFS to surgical resection, but RFA is less invasive.


Radiofrequency ablation Hepatectomy Hepatocellular carcinoma 


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Copyright information

© The Society for Surgery of the Alimentary Tract 2010

Authors and Affiliations

  • Jiwei Huang
    • 1
  • Roberto Hernandez-Alejandro
    • 2
  • Kristopher P. Croome
    • 2
  • Lvnan Yan
    • 1
  • Hong Wu
    • 1
  • Zheyu Chen
    • 1
  • Pankaj Prasoon
    • 1
  • Yong Zeng
    • 1
  1. 1.Department of Hepato-Biliary-Pancreatic Surgery, Treatment Centre of Liver Cancer, West China HospitalSichuan UniversityChengduChina
  2. 2.From Department of SurgeryUniversity of Western Ontario, Hepatobiliary and Liver Transplant Surgery, London Health Sciences CentreLondonCanada

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